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Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating optimized methods for optimal products.
Lithium Process Chemistry: Resources, Extraction, Batteries and Recycling presents, for the first time, the most recent developments and state-of-the-art of lithium production, lithium-ion batteries, and their recycling. The book provides fundamental and theoretical knowledge on hydrometallurgy and electrochemistry in lithium-ion batteries, including terminology related to these two fields. It is of particular interest to electrochemists who usually have no knowledge in hydrometallurgy and hydrometallurgists not familiar with electrochemistry applied to Li-ion batteries. It is also useful for both teachers and students, presenting an overview on Li production, Li-ion battery technologies, and lithium battery recycling processes that is accompanied by numerous graphical presentations of different battery systems and their electrochemical performances. The book represents the first time that hydrometallurgy and electrochemistry on lithium-ion batteries are assembled in one unique source. Provides fundamental and theoretical knowledge on hydrometallurgy and electrochemistry in lithium-ion batteries Represents the first time that hydrometallurgy and electrochemistry on lithium-ion batteries are assembled in one unique source. Ideal for both electrochemists who usually have no knowledge in hydrometallurgy and hydrometallurgists not familiar with electrochemistry applied to Li-ion batteries Presents recent developments, as well as challenges in lithium production and lithium-ion battery technologies and their recycling Covers examples of Li processes production with schematics, also including numerous graphical presentations of different battery systems and their electrochemical performances
Images and text capture the astonishing beauty of the chemical processes that create snowflakes, bubbles, flames, and other wonders of nature. Chemistry is not just about microscopic atoms doing inscrutable things; it is the process that makes flowers and galaxies. We rely on it for bread-baking, vegetable-growing, and producing the materials of daily life. In stunning images and illuminating text, this book captures chemistry as it unfolds. Using such techniques as microphotography, time-lapse photography, and infrared thermal imaging, The Beauty of Chemistry shows us how chemistry underpins the formation of snowflakes, the science of champagne, the colors of flowers, and other wonders of nature and technology. We see the marvelous configurations of chemical gardens; the amazing transformations of evaporation, distillation, and precipitation; heat made visible; and more.
Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers—offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, Process Chemistry in the Pharmaceutical Industry is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.
Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances. Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical ingredients.
Illustrating all aspects of chemical process design, this book demonstrates process synthesis, material and heat balancing by manual and computerised methods, the use of flowsheeting programs and their construction, flowsheet development, plant safety, process economics and project engineering. The reader is introduced to each of the key areas and is given further information to follow these up. The process is developed as a whole entity with appropriate partitioning of certain tasks. In recent years, there has been increased activity in process synthesis, particularly in the development of heat exchanger networks and distillation trains. Various chapters describe and develop these and other areas of interest. In particular, note is made of the need to select appropriate unit operations for given process tasks. Traditional manual methods of material and heat balancing introduce the computerised methods used in flowsheeting programs. Plant safety continues to generate professional and public interest as catastrophes continue to occur. The recent developments in this area are described.
This book shows the diversity of structural problems and synthesis solution as well as the practical aspects and methodologies required for large-scale syntheses. The eleven chapters focus on chemical process research in the pharmaceutical industry.
The story of this little-known Dutch physician “will interest students and practitioners of history, chemistry, and philosophy of science” (Choice). In Inventing Chemistry, historian John C. Powers turns his attention to Herman Boerhaave (1668–1738), a Dutch medical and chemical professor whose work reached a wide, educated audience and became the template for chemical knowledge in the eighteenth century. The primary focus of this study is Boerhaave’s educational philosophy, and Powers traces its development from Boerhaave’s early days as a student in Leiden through his publication of the Elementa chemiae in 1732. Powers reveals how Boerhaave restructured and reinterpreted various practices from diverse chemical traditions (including craft chemistry, Paracelsian medical chemistry, and alchemy), shaping them into a chemical course that conformed to the pedagogical and philosophical norms of Leiden University’s medical faculty. In doing so, Boerhaave gave his chemistry a coherent organizational structure and philosophical foundation, and thus transformed an artisanal practice into an academic discipline. Inventing Chemistry is essential reading for historians of chemistry, medicine, and academic life.
The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.
As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explor