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A gripping investigation into the U.S. Army scientist alleged to be behind the 2001 anthrax attacks.
This fourth edition of the anthrax guidelines encompasses a systematic review of the extensive new scientific literature and relevant publications up to end 2007 including all the new information that emerged in the 3-4 years after the anthrax letter events. This updated edition provides information on the disease and its importance, its etiology and ecology, and offers guidance on the detection, diagnostic, epidemiology, disinfection and decontamination, treatment and prophylaxis procedures, as well as control and surveillance processes for anthrax in humans and animals. With two rounds of a rigorous peer-review process, it is a relevant source of information for the management of anthrax in humans and animals.
For the first time, Pulitzer Prize–winning journalist David Willman tells the whole gripping story of the hunt for the anthrax killer who terrorized the country in the dark days that followed the September 11th attacks. Letters sent surreptitiously from a mailbox in New Jersey to media and political figures in New York, Florida, and Washington D.C. killed five people and infected seventeen others. For years, the case remained officially unsolved—and it consumed the FBI and became a rallying point for launching the Iraq War. Far from Baghdad, at Fort Detrick, Maryland, stood Bruce Ivins: an accomplished microbiologist at work on patenting a next-generation anthrax vaccine. Ivins, it turned out, also was a man the FBI consulted frequently to learn the science behind the attacks. The Mirage Man reveals how this seemingly harmless if eccentric scientist hid a sinister secret life from his closest associates and family, and how the trail of genetic and circumstantial evidence led inexorably to him. Along the way, Willman exposes the faulty investigative work that led to the public smearing of the wrong man, Steven Hatfill, a scientist specializing in biowarfare preparedness whose life was upended by media stakeouts and op-ed-page witch hunts. Engrossing and unsparing, The Mirage Man is a portrait of a deeply troubled scientist who for more than twenty years had unlimited access to the U.S. Army’s stocks of deadly anthrax. It is also the story of a struggle for control within the FBI investigation, the missteps of an overzealous press, and how a cadre of government officials disregarded scientific data while spinning the letter attacks into a basis for war. As The Mirage Man makes clear, America must, at last, come to terms with the lessons to be learned from what Bruce Ivins wrought. The nation’s security depends on it. From the Hardcover edition.
The vaccine used to protect humans against the anthrax disease, called Anthrax Vaccine Adsorbed (AVA), was licensed in 1970. It was initially used to protect people who might be exposed to anthrax where they worked, such as veterinarians and textile plant workers who process animal hair. When the U. S. military began to administer the vaccine, then extended a plan for the mandatory vaccination of all U. S. service members, some raised concerns about the safety and efficacy of AVA and the manufacture of the vaccine. In response to these and other concerns, Congress directed the Department of Defense to support an independent examination of AVA. The Anthrax Vaccine: Is It Safe? Does It Work? reports the study's conclusion that the vaccine is acceptably safe and effective in protecting humans against anthrax. The book also includes a description of advances needed in main areas: improving the way the vaccine is now used, expanding surveillance efforts to detect side effects from its use, and developing a better vaccine.
It was September 18, 2001, just seven days after al-Qaeda hijackers destroyed the Twin Towers. In the early morning darkness, a lone figure dropped several letters into a mailbox. Seventeen days later a Florida journalist died of inhalational anthrax. The death from the rare disease made world news. These anthrax attacks marked the first time a sophisticated biological weapon was released in the United States. It killed five people, disfigured at least 18 more, and launched the largest investigation in the FBI’s history. Recounting the Anthrax Attacks explores the origins of the innovative forensics used in this case, while also explaining their historical context. R. Scott Decker’s team pursued its first suspect with dogged determination before realizing that the evidence did not add up. With renewed energy, they turned to non-traditional forensics—scientific initiatives never before applied to an investigation—as they continued to hunt for clues. These advances formed the new science of microbial forensics, a novel discipline that produced critical leads when traditional methods failed. The new technologies helped identify a second suspect—one who possessed the knowledge and skills to unleash a living weapon of mass destruction. Decker provides the first inside look at how the investigation was conducted, highlighting dramatic turning points as the case progressed until its final solution. Join FBI agents as they race against terror and the ultimate insider threat—a decorated government scientist releasing powders of deadly anthrax. Walk in the steps of these dedicated officers while they pursue numerous forensic leads before more letters can be sent until finally they confront a psychotic killer.
Bacillus anthracis causes anthrax in all mammals, including humans. Depending upon the route of entry of B. anthracis spores, infection can result in cutaneous lesions, which are readily treatable with antibiotics, or systemic lethal disease, which is nearly always fatal. The continuing worldwide incidence of anthrax in animal populations, the risk of human infection associated with animal outbreaks, and the threat of use of B. anthracis as a biological weapon warrant continued investigation of this organisms and its virulence mechanims. Furthermore, B. anthracis is an excellent model system for inverstigation of virulence gene expression by bacteria.
This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.
Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.
Significant advances in our knowledge of genetics were made during the twentieth century but in the most recent decades, genetic research has dramatically increased its impact throughout society. Genetic issues are now playing a large role in health and public policy, and new knowledge in this field will continue to have significant implications for individuals and society. Written for the non-majors human genetics course, Human Genetics, Third Edition will increase the genetics knowledge of students who are learning about human genetics for the first time. This thorough revision of the best-selling Human Genome, Second Edition includes entirely new chapters on forensics, stem cell biology, bioinformatics, and societal/ethical issues associated with the field. New special features boxes make connections between human genetics and human health and disease. Carefully crafted pedagogy includes chapter-opening case studies that set the stage for each chapter; concept statements interspersed throughout the chapter that keep first-time students focused on key concepts; and end-of-chapter questions and critical thinking activities. This new edition will contribute to creating a genetically literate student population that understands basic biological research, understands elements of the personal and health implications of genetics, and participates effectively in public policy issues involving genetic information. - Includes topical material on forensics, disease studies, and the human genome project to engage non-specialist students - Full, 4-color illustration program enhances and reinforces key concepts and themes - Uniform organization of chapters includes interest boxes that focus on human health and disease, chapter-opening case studies, and concept statements to engage non-specialist readers
Enjoy this free explosive, pulse-pounding action thriller series by USA Today Bestselling author Steve P. Vincent… A simple mission gone wrong Mitch Herron's business is death and business is good. An assassin without equal, Herron is sent on missions around the world by his shadowy employers, where he cuts down his targets with no second thoughts. His latest mission: eradicate a group of terrorists hell-bent on cleansing the planet with a highly virulent biological weapon. But the latest job is no walk in the park, because Herron is captured and turned into a deadly weapon of a different kind... A desperate battle to stop a catastrophe With only days before he's used to help spread the most lethal contagion in human history, Herron knows he might be the only person able to hunt down the fanatics and stop their attack. But to foil the conspiracy, Herron will have to disobey his training and his employers, putting a target on his own back. As he chases the terrorists across America, action is never far away, and failure will mean death for more than just himself. The clock is ticking.... All thriller, no filler! If you like David Archer’s Noah Wolf series, Mark Dawson’s John Milton series, or Steven Konkoly’s Black Flag series, you’ll love the addictive Mitch Herron action thriller series. Start the series now with this FREE book!