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The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression
Reviews the current literature on tumors at rare sites and uncommon tumors of specific type. Specialists from the UK, USA, Europe, Japan and Australia discuss recent research on a wide range of different cancers and describe their own unique clinical experiences. Each chapter deals with a different type of cancer such as gynecological tumors, thoracic tumors, tumors of the nervous system and head tumors, and covers the biology, pathology, diagnosis and treatment of each. Specifically designed to help those responsible for patient management, particularly the practicing clinician, in order to provide the optimal management for patients with uncommon cancers.
The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression
Mark’s journey and battle with cancer at the young age of fifty-one came as a complete shock as you can imagine. Eating right, exercising, and living for the future instead of living for the moment was Mark’s approach to life. “I want to be healthy,” he said, ready for his golden years, but then suddenly, within just a few short months, everything fell apart! Progressing from no symptoms whatsoever to advanced stage-four non-Hodgkin Burkitt lymphoma in less than three months, Mark was in big, big trouble! He had been diagnosed with one of the most aggressive forms of cancer anyone can get, and so his battle to survive began with the help from his wife and over thirty doctors. Mark poses an interesting question in this book that asks you to reflect on your life, back to the first memories from your childhood. How do our choices in life and the consequences of those choices affect our life’s path? Those decisions can ultimately determine our physical and mental health?
Described as ‘must-have for cancer research’ by theHospital Doctor this highly acclaimed textbook has beenextensively revised and updated to reflect recent progress andunderstanding in the field. It is the only comprehensive source ofinformation available on uncommon cancers; presenting diagnosis,detailed clinical management and prognosis. The Textbook ofUncommon Cancer, Third Edition incorporated 18 newchapters, including: Tumors of the cervix Esthesioneuroblastoma Unusual malignancies of plasma cells Dermatofibrosarcoma protuberans Written by leading clinicians worldwide, this title isindispensable for all those involved in the diagnosis and treatmentof hard-to-manage rare tumors.
Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease. This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common. - Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseases - Stresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathology - Discusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchers - Offers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases
After reviewing the history of cancer and its impact on the population, Dr. Faguet exposes the antiquated notions that have driven cancer drug development, documents the stagnation in treatment outcomes despite major advances in cancer genomics and growing NCI budgets, and identifies the multiple factors that sustain the status quo. He shows that, contrary to frequent announcements of breakthroughs, our current cancer control model cannot eradicate most cancers and the reasons why. Significantly, this book also delineates a way forward via a shift from the discredited cell-kill approach of the past to an integrated, evidence-driven cancer control paradigm based on prevention, early diagnosis, and pharmacogenomics. The author's views are based on data published in mainstream scientific journals and other reliable references, 432 of which are cited.
The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.
In the fast-changing age of precision medicine, PET/CT is increasingly important for accurate cancer staging and evaluation of treatment response. Fundamentals of Oncologic PET/CT, by Dr. Gary A. Ulaner, offers an organized, systematic introduction to reading and interpreting PET/CT studies, ideal for radiology and nuclear medicine residents, practicing radiologists, medical oncologists, and radiation oncologists. Synthesizing eight years' worth of cases and lectures from one of the largest cancer centers in the world, this title provides a real-world, practical approach, taking you through the body organ by organ as it explains how to integrate both the FDG PET and CT findings to best interpret each lesion. - Based on the Annual Oncologic PET/CT Continuing Education Course founded and directed by Dr. Ulaner. - Provides step-by-step guidance on how to interpret PET/CT images for patients with cancer. - Uses a unique, highly practical format, presenting common and uncommon findings for each organ system, and then explaining how to best arrive at a diagnosis for those findings. - Describes how to integrate PET findings with CT, MR, ultrasound, and radiography, to increase specificity of PET findings. - Features more than 1,000 high-quality PET, CT, and correlative radiographic images, with over 600 in full color. - Discusses how to avoid common interpretive pitfalls. - Demonstrates how to organize an FDG PET/CT report efficiently and concisely. - Includes a separate chapter on novel radiotracers – including Sodium Fluoride, DOTATATE, Choline, Fluciclovine, and PSMA targeting agents. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Gastroesophageal cancers are the most common form of cancer incidents, and the second most common cause of death among cancer patients. In 2000, it was estimated that over one million new cases of gastroesophageal cancers were diagnosed worldwide, and over 900,000 individuals died from the disease. Using a multi-disciplinary approach, Esophageal Cancer: Principles and Practice addresses the complexities encountered in the understanding and management of esophageal cancers. Written by the worldÌs leading experts in surgery, medical oncology, radiation oncology, gastroenterology, pathology, radiology, nutrition, nurse specialists, palliative medicine, and research relating to neoplasia of the esophagus, this text will serve as the definitive resource and enable practitioners to provide the best possible patient care. Presented in an accessible and useful format, this text is a valuable reference to all practitioners participating in the care of this high-needs population. Special Features Include: Complete coverage of the two most common tumors: squamous cell carcinoma and adenocarcinoma In-depth coverage of uncommon tumors In-depth coverage of each topic with equal emphasis applied to both technical and multidisciplinary aspects of treatment In-depth treatment of non-surgical topics in management at different phases of the disease Wide-ranging attention to the diseaseÌs biologic aspects and basic science, contributing greatly to palliative care