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Textbook of Pharmaceutical Organic Chemistry-II. Covers topics such as Benzene, Phenols, Aromatic acids, Aromatic amines, Fats and Oils, Polycyclic compounds, and Cycloalkanes. This Book gives a deep insight into methods of preparation and reaction of organic compounds with their mechanism. The Acidity, Basicity, reaction, Resonance energy, resonance structure, orbital pictures, etc. are also taken in depth. Nomenclature, classification, and qualitative tests were presented in a very easy manner. Applications of every compound were been taken. Different derivatives were been tabulated in a sequential manner.
Importance And Scope Of Medicinal Plants 1 2. Classification Of Crude Drugs 6 3. Drug Adulteration 16 4. Biogenesis Of Phyto-Pharmaceuticals And Basic Metabolic Pathways 45 5. Chemical Nature Of Phytoconstituents 62 6. Extraction Techniques 74 7. Industrial Production And Analysis Of Phytoconstituents 79 8. Marine Pharmacognosy 99 9. Indigenous System Of Medicines 107 10. Plant Tissue Culture 130 11. Pharmaceutical Enzymes 136 12. Primary Metabolites 141 12.1 Carbohydrates 141 12.2 Proteins 166 12.3 Lipids 175 13. Secondary Metabolites 207 13.1 Alkaloids 207 13.2 Glycosides 228 13.3 Tannins 245 13.4 Terpenoids 252 13.5 Resins And Resin Combinations 262 14. Plant Fibres 267 15. Natural Dyes 273 Question Papers
The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.
A Clear And Reliable Guide To Students Of Practical Organic Chemistry At The Undergraduate And Postgraduate Levels. This Edition S Special Emphasis Is On Semi Micro Methods And Modern Techniques And Reactions.
Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.
1 Introduction to pharmaceutics 2 Pharmacopoeia and other compendia 3 Alternative systems of medicines 4 Introduction to drug and dosage forms 5 Excipients 6 Pre formulation 7 Solution 8 Concept of quality control and quality assurance Bibliograpgy Glossary Index
Topics 1. Introduction 2. Calibration Of Volumetric Apparatus 3. Preparation And Standardisation Of Standard Solutions 4. Indicators 5. Neutralisation Titrations 6. Non-Aqueous Titrations 7. Oxidation-Reduction Titrations 8. Precipitation Titrations 9. Complexometric Titrations 10. Special Category Of Volumetric Methods Of Analysis 11. Gravimetric Analysis
This book serves as a formulation and processing guide during the development of pelletized dosage forms. It provides the pharmaceutical technologist with basic information about the design aspects of the relevant processing equipment.