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This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.
The concept of a socially constructed space of human activity in areas of everyday actions, as initially proposed in the field of anthropology by Tim Ingold, has actually been much more applied in archaeology. In this wide-ranging collection of 13 papers, including a re-assessment by Ingold himself, contributors show why it has been so influential, with papers ranging from the study of Mesolithic to historic and contemporary archaeology, revisiting different research themes, such as Ingold’s own Lapland study, and the development of landscape archaeology. A series of case studies demonstrates the value and strength of the taskscape concept applied to a variety of contexts and scales across wide geographical and temporal situations. While exploring new frontiers, the papers contrast British, Nordic and Mediterranean archaeologies to showcase the study of material culture and landscape and conclude with an assessment of the concept of taskcape and its further developments.
This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Formal Modeling and Analysis of Timed Systems, FORMATS 2003, held in Marseille, France in September 2003. The 19 revised full papers presented together with an invited paper and the abstracts of two invited talks were carefully selected from 36 submissions during two rounds of reviewing and improvement. All current aspects of formal method for modeling and analyzing timed systems are addressed; among the timed systems dealt with are timed automata, timed Petri nets, max-plus algebras, real-time systems, discrete time systems, timed languages, and real-time operating systems.
CHARME’99 is the tenth in a series of working conferences devoted to the dev- opment and use of leading-edge formal techniques and tools for the design and veri?cation of hardware and systems. Previous conferences have been held in Darmstadt (1984), Edinburgh (1985), Grenoble (1986), Glasgow (1988), Leuven (1989), Torino (1991), Arles (1993), Frankfurt (1995) and Montreal (1997). This workshop and conference series has been organized in cooperation with IFIP WG 10. 5. It is now the biannual counterpart of FMCAD, which takes place every even-numbered year in the USA. The 1999 event took place in Bad Her- nalb, a resort village located in the Black Forest close to the city of Karlsruhe. The validation of functional and timing behavior is a major bottleneck in current VLSI design systems. A predominantly academic area of study until a few years ago, formal design and veri?cation techniques are now migrating into industrial use. The aim of CHARME’99 is to bring together researchers and users from academia and industry working in this active area of research. Two invited talks illustrate major current trends: the presentation by G ́erard Berry (Ecole des Mines de Paris, Sophia-Antipolis, France) is concerned with the use of synchronous languages in circuit design, and the talk given by Peter Jansen (BMW, Munich, Germany) demonstrates an application of formal methods in an industrial environment. The program also includes 20 regular presentations and 12 short presentations/poster exhibitions that have been selected from the 48 submitted papers.