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The I. Beritashvili Center of Experimental Biomedicine was established in 2010 on the basis of merging four well-known Georgian research institutes. They are: The I. Beritashvili Institute of Physiology, one of the most prominent research centers of Georgia, where basic and applied research in different fields of neurophysiology has been conducted since 1935; the Institute of Molecular Biology and Biophysics; the Center for Radiology and Radiation Ecology, which for many years operated as departments at the I. Beritashvili Institute of Physiology; and one of the leading research centers for Georgia: The Center of Experimental Neurology. This edited book is the second volume containing chapters constituting the research priorities of the I. Beritashvili Center of Experimental Biomedicine and covers the experimental study of fundamental issues in the functioning of physiological (mainly, neurophysiological) mechanisms during normal and pathological conditions. The first book Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders published by Nova Science Publishers Inc. in 2015, was also devoted to the same general problems. In the present edited book, particular attention is drawn to the study of extremely important processes underlying the basic mechanisms and disorders of various phenomenon of integrative activity of the brain: General behavior, learning and memory processes, the sleep-wakefulness cycle, regulation of adequate blood supply, hormesis, vision, depression, experimental comatose state, epilepsy, tumor diseases, pain and analgesia, the state of anxiety and aggression. All of the mentioned processes are studied on the molecular, cellular and systemic levels of their organization. It has to be noted herewith that each chapter within the collection of works represents the results of separate, independent studies implemented by different scientific departments of the Center; therefore, the chapters are not directly related to each other and have been arranged alphabetically based on the surnames of the authors. The authors would like to take this opportunity and present to the reader the scientific and institutional infrastructure of the Center, which consists of departments and laboratories. Nowadays, the Center is comprised of seven departments: Neurophysiology, Membranology, Biochemistry, Blood Circulation and Metabolism, Neurotoxicology, Biophysics and Radiobiology and nine laboratories: Behavior and Cognitive Functions, Physiology of Vision, Neurobiology of Sleep-Wakefulness Cycle, Ultra- and Nanoarchitectonics of the Brain, Experimental Neurology, Pain and Analgesia, Bioinformatics, Structure and Function of Genomes, and the Problems of Radiation Safety. In addition to bilateral scientific cooperation with many famous European and American scientific institutions, the Center is a member of the International Science Consortium From Molecular to Cellular Events in Human Pathologies, of which the 2015 Annual Meeting was held in Tbilisi. The authors are sure that readers are fully aware of the theoretical and practical importance of the research related to problems of systemic, cellular and molecular mechanisms of physiological functions and their disorders. The presented collection of works contains the results of relevant research conducted over the last three years (2015-2018). The authors will be very grateful for any feedback, recommendations and suggestions regarding their research for the implementation of which they have invested a lot of effort, time, knowledge and experience.
The I. Beritashvili Center of Experimental Biomedicine was established in 2010 on the basis of merging four well-known Georgian research institutes. They are: The I. Beritashvili Institute of Physiology, one of the most prominent research centers of Georgia, where basic and applied research in different fields of neurophysiology has been conducted since 1935; the Institute of Molecular Biology and Biophysics; the Center for Radiology and Radiation Ecology, which for many years operated as departments at the I. Beritashvili Institute of Physiology; and one of the leading research centers for Georgia: The Center of Experimental Neurology.This edited book is the second volume containing chapters constituting the research priorities of the I. Beritashvili Center of Experimental Biomedicine and covers the experimental study of fundamental issues in the functioning of physiological (mainly, neurophysiological) mechanisms during normal and pathological conditions. The first book - Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders - published by Nova Science Publishers Inc. in 2015, was also devoted to the same general problems.In the present edited book, particular attention is drawn to the study of extremely important processes underlying the basic mechanisms and disorders of various phenomenon of integrative activity of the brain: General behavior, learning and memory processes, the sleep-wakefulness cycle, regulation of adequate blood supply, hormesis, vision, depression, experimental comatose state, epilepsy, tumor diseases, pain and analgesia, the state of anxiety and aggression. All of the mentioned processes are studied on the molecular, cellular and systemic levels of their organization. It has to be noted herewith that each chapter within the collection of works represents the results of separate, independent studies implemented by different scientific departments of the Center; therefore, the chapters are not directly related to each other and have been arranged alphabetically based on the surnames of the authors. The authors would like to take this opportunity and present to the reader the scientific and institutional infrastructure of the Center, which consists of departments and laboratories.Nowadays, the Center is comprised of seven departments: Neurophysiology, Membranology, Biochemistry, Blood Circulation and Metabolism, Neurotoxicology, Biophysics and Radiobiology and nine laboratories: Behavior and Cognitive Functions, Physiology of Vision, Neurobiology of Sleep-Wakefulness Cycle, Ultra- and Nanoarchitectonics of the Brain, Experimental Neurology, Pain and Analgesia, Bioinformatics, Structure and Function of Genomes, and the Problems of Radiation Safety.In addition to bilateral scientific cooperation with many famous European and American scientific institutions, the Center is a member of the International Science Consortium "From Molecular to Cellular Events in Human Pathologies", of which the 2015 Annual Meeting was held in Tbilisi.The authors are sure that readers are fully aware of the theoretical and practical importance of the research related to problems of systemic, cellular and molecular mechanisms of physiological functions and their disorders. The presented collection of works contains the results of relevant research conducted over the last three years (2015-2018).The authors will be very grateful for any feedback, recommendations and suggestions regarding their research for the implementation of which they have invested a lot of effort, time, knowledge and experience.
The Ivane Beritashvili Center of Experimental Biomedicine was established in 2010 on the basis of the well-known Ivane Beritashvili Institute of Physiology, the most prominent research center of Georgia, where basic and applied research in different fields of neurophysiology has been conducted since its foundation.Professor Ivane Beritashvili was a famous Georgian scientist who gained international recognition during his lifetime. He was one of the founders and members of the Georgian Academy of Sciences and a member of three academies of sciences of the former Soviet Union. He was an honorary member of the New York Academy of Sciences, the American Society of Electroencephalography, the Royal Society of England, the American Society of Biological Psychiatry, and an honorary member of the International Brain Research Organization. He was an honored scientist of Georgia, a laureate of the State Prize, and a recipient of many orders and medals.Ivane Beritashvili is remembered in history as a person who founded the Department of Physiology at the newly opened Tbilisi State University. He developed physiological terminology in Georgian, wrote a textbook of physiology in Georgian for the students of the university, raised successful scientists from the first generation of his students, and founded the Georgian School of Physiology. In 1935, he founded the Institute of Physiology in Tbilisi, which soon gained recognition and became well-respected by a wide range of foreign scientists who often visited Georgia. In 2010, three scientific institutions were merged with the Ivane Beritashvili Institute of Physiology - the Institute of Molecular Biology and Biophysics, the Center of Radiobiology and Radiation Ecology and the Center of Experimental Neurology, the first two of which, for many years, were the departments of the Institute of Physiology. This edited book is the third such compilation containing chapters that represent the research priorities of the Ivane Beritashvili Center of Experimental Biomedicine, which covers the experimental study of fundamental issues in the functioning of physiological (mainly neurophysiological) mechanisms during normal and pathological conditions. The first and second books - "Systemic, Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders" - published by Nova Science Publishers Inc. in 2015 and 2018, were also devoted to the same general problems.In the present edited book, particular attention is drawn to the study of extremely important processes underlying the basic mechanisms and disorders of various phenomenon of integrative activity of the brain: general behavior, learning and memory, the sleep-wakefulness cycle, regulation of adequate blood supply, hormesis, epilepsy, depression, sleep disorders, pain and analgesia. All of the mentioned processes are studied on the molecular, cellular and systemic levels of their organization. It has to be noted that each chapter, within the collection of works, represents the results of separate, independent studies implemented by different scientific departments of the center. Therefore, the chapters are not directly related to each other and have been arranged alphabetically based on the surname of the authors. The authors would like to take this opportunity to present to the reader the scientific and institutional infrastructure of the center, which consists of departments and laboratories. Nowadays the center consists of seven departments: Neurophysiology, Membranology, Biochemistry, Blood Circulation and Metabolism, Neurotoxicology, Membranology, Biophysics and Radiobiology and nine laboratories: Neurobiology of Sleep-Wakefulness Cycle, Vision Physiology, Behavior and Cognitive Functions, Brain Ultra- and Nano-Architectonics, Experimental Neurology, Pain and Analgesia, Structure and Functions of Genomes, Bioinformatics, and the Problems of Radiation Safety.In addition to the bilateral scientific cooperation with famous European and U.S. scientific institutions, the center is a member of the International Science Consortium "From Molecule to Cellular Events in Human Pathologies", the annual meeting of which was held in Tbilisi in 2015.The authors are confident that the readers are fully aware of the theoretical and practical importance of the research related to the problems of systemic, cellular and molecular mechanisms of physiological functions and their disorders. The presented collection of works contains the results of relevant research conducted over the last three years (2019-2021).The authors will be grateful for feedback, recommendations and suggestions regarding their research, in the implementation of which they have invested a lot of effort, knowledge and experience.
Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field
Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense
"Recently, an interest in our understanding of well-being within the context of competition and cooperation has re-emerged within the biological and neural sciences. Given that we are social animals, our well-being is tightly linked to interactions with others. Pro-social behavior establishes and sustains human contact, contributing to well-being. Adaptation and Well-Being is about the evolution and biological importance of social contact. Social sensibility is an essential feature of our central nervous systems, and what have evolved are elaborate behavioral ways in which to sustain and maintain the physiological and endocrine systems that underlie behavioral adaptations. Writing for his fellow academics, and with chapters on evolutionary aspects, chemical messengers and social neuroendocrinology among others, Jay Schulkin explores this fascinating field of behavioral neuroscience"--