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A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.
Biological Systematics: Principles and Applications draws equally from examples in botany and zoology to provide a modern account of cladistic principles and techniques. It is a core systematics textbook with a focus on parsimony-based approaches for students and biologists interested in systematics and comparative biology. Randall T. Schuh and Andrew V. Z. Brower cover: -the history and philosophy of systematics and nomenclature; -the mechanics and methods of analysis and evaluation of results; -the practical applications of results and wider relevance within biological classification, biogeography, adaptation and coevolution, biodiversity, and conservation; and -software applications. This new and thoroughly revised edition reflects the exponential growth in the use of DNA sequence data in systematics. New data techniques and a notable increase in the number of examples from molecular systematics will be of interest to students increasingly involved in molecular and genetic work.
Evolution.
The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers, and interdisciplinary scholars investigating the social and educational aspects of systems biology. In response to the same set of questions, the experts develop and defend their personal perspectives on the distinctive character of systems biology and the challenges that lie ahead. Readers are invited to engage with different views on the questions addressed, and may explore numerous themes relating to the philosophy of systems biology. This edited work will appeal to scholars and all levels, from undergraduates to researchers, and to those interested in a variety of scholarly approaches such as systems biology, mathematical and computational modelling, cell and molecular biology, genomics, systems theory, and of course, philosophy of biology.
To some potential readers of this book the description of Biological System atics as an art may seem outdated and frankly wrong. For most people art is subjective and unconstrained by universal laws. While one picture, play or poem may be internally consistent comparison between different art products is meaningless except by way of the individual artists. On the other hand modern Biological Systematics - particularly phenetics and cladistics - is offered as objective and ultimately governed by universal laws. This implies that classifications of different groups of organisms, being the products of systematics, should be comparable irrespective of authorship. Throughout this book Minelli justifies his title by developing the theme that biological classifications are, in fact, very unequal in their expressions of the pattern and processes of the natural world. Specialists are imbibed with their own groups and tend to establish a consensus of what constitutes a species or a genus, or whether it should be desirable to recognize sub species, cultivars etc. Ornithologists freely recognize subspecies and rarely do bird genera contain more than 10 species. On the other hand some coleopterists and botanists work with genera with over 1500 species. This asymmetry may reflect a biological reality; it may express a working practicality, or simply an historical artefact (older erected genera often contain more species). Rarely are these phenomena questioned.
This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems biology has been included.
This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers
Anyone interested in comparative biology or the history of science will find this myth-busting work genuinely fascinating. It draws attention to the seminal studies and important advances that have shaped systematic and biogeographic thinking. It traces concepts in homology and classification from the 19th century to the present through the provision of a unique anthology of scientific writings from Goethe, Agassiz, Owen, Naef, Zangerl and Nelson, among others.