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This work investigated a novel photochemical cyclization to form indole derivatives from o-alkynylated F-tagged aniline derivatives, and wide applicability to synthesize differently functionalized indole systems bearing various substituents in the positions N-1, C-2, C-3, C-5 and C-6 was shown. Additionally, this reaction was systematically studied in a kinetic study in an in-house assembled capillary photo-microreactor. Further derivatization of the final F-tagged 3-acylindoles by the cleavage of the perfluorinated chain yielded a library of novel indole-3-carboxylic acid and indole-3-carboxylic acid ester derivatives. A straightforward and efficient four-step methodology for the synthesis of desired indole derivatives with high yields for single steps and the whole sequence was developed. Variing the conditions of single steps showed that all three steps of the reaction route to the cyclization precursors can be performed using the same solvent and base, providing the possibility to conduct this sequence as a continuous-flow without the need for in-line solvent switch or base exchange and without compromises with respect to the selectivity and yields of single steps.
The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal.
Photochemistry of Organic Compounds: From Concepts to Practice provides a hands-on guide demonstrating the underlying principles of photochemistry and, by reference to a range of organic reaction types, its effective use in the synthesis of new organic compounds and in various applications. The book presents a complete and methodical approach to the topic, Working from basic principles, discussing key techniques and studies of reactive intermediates, and illustrating synthetic photochemical procedures. Incorporating special topics and case studies covering various applications of photochemistry in chemistry, environmental sciences, biochemistry, physics, medicine, and industry. Providing extensive references to the original literature and to review articles. Concluding with a chapter on retrosynthetic photochemistry, listing key reactions to aid the reader in designing their own synthetic pathways. This book will be a valuable source of information and inspiration for postgraduates as well as professionals from a wide range of chemical and natural sciences.
Filling the gap in the market for comprehensive coverage of this hot topic, this timely book covers a wide range of organic transformations, e. g. reductions of unsaturated compounds, oxidation reactions, Friedel-Crafts reactions, hydroamination reactions, depolymerizations, transformations of carbon dioxide, oxidative coupling reactions, as well as C-C, C-N, and C-O bond formation reactions. A chapter on the application of zinc catalysts in total synthesis is also included. With its aim of stimulating further research and discussion in the field, this is a valuable reference for professionals in academia and industry wishing to learn about the latest developments.
Have you ever wished you could speed up your organic syntheses without losing control of the reaction? Flash Chemistry is a new concept which offers an integrated scheme for fast, controlled organic synthesis. It brings together the generation of highly reactive species and their reactions in Microsystems to enable highly controlled organic syntheses on a preparative scale in timescales of a few seconds or less. Flash Chemistry: Fast Organic Synthesis in microsystems is the first book to describe this exciting new technique, with chapters covering: an introduction to flash chemistry reaction dynamics: how fast is the act of chemical transformation, what is the rate of reaction, and what determines the selectivity of a reaction? examples of why flash chemistry is needed: the rapid construction of chemical libraries, rapid synthesis of radioactive PET probes, and on-demand rapid synthesis in industry the generation of highly reactive species through thermal, microwave, chemical, photochemical, and electrochemical activation microsystems: What are microsystems and how are they made? Why is size so important? What are the characteristic features of microsystems? conduction and control of extremely fast reactions using microsystems applications of flash chemistry in organic synthesis polymer synthesis based on flash chemistry industrial applications of flash chemistry Flash Chemistry: Fast Organic Synthesis in Microsystems is an essential introduction to anyone working in organic synthesis, process chemistry, chemical engineering and physical organic chemistry concerned with fundamental aspects of chemical reactions an d synthesis and the production of organic compounds.
Continuous-flow photochemistry is an expanding field within chemistry. It unites the mass transfer enhancement of flow chemistry with the high energy field density of microscale geometries. Moreover, it provides means to scale photochemical reactions efficiently.This book gives an overview of both technological and chemical aspects associated with photochemical processes in microreactors. It provides analysis, the first of its kind, of these new technologies developed within the field of photochemical processes, with a description and case studies of practical implementation. It specifically looks at:By providing a deeper understanding of underlying concepts, coupled with numerous examples, this book is an essential reference for chemistry students, researchers and professionals working on photochemistry, photoredox catalysis, flow chemistry, process chemistry and reactor engineering.
By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!
Flow analysis is an automatic, precise and fast way to perform analytical tests. Flow instruments are used for clinical and pharmaceutical analyses, quality control of industrial products, monitoring of environmental pollution and many other fields. The book presents the latest methodological, technical and instrumental achievements in flow analysis. It shows new possibilities for the miniaturization and full mechanization of flow systems, together with examples of their interesting application. The proposed solutions contribute to reducing the amount of used reagents and waste, as well as increasing the safety of working with hazardous reagents, resulting in modern devices operating in accordance with the principles of green chemistry. A number of innovative methods of processing and measuring analytical samples have also been described. The book very well reflects the current state of flow analysis and development directions.
"Flow Chemistry fills the gap in graduate education by covering chemistry and reaction principles along with current practice, including examples of relevant commercial reaction, separation, automation, and analytical equipment. The Editors of Flow Chemistry are commended for having taken the initiative to bring together experts from the field to provide a comprehensive treatment of fundamental and practical considerations underlying flow chemistry. It promises to become a useful study text and as well as reference for the graduate students and practitioners of flow chemistry." Professor Klavs Jensen Massachusetts Institute of Technology, USA Broader theoretical insight in driving a chemical reaction automatically opens the window towards new technologies particularly to flow chemistry. This emerging concept promotes the transformation of present day's organic processes into a more rapid continuous set of synthesis operations, more compatible with the envisioned sustainable world. These two volumes Fundamentals and Applications provide both the theoretical foundation as well as the practical aspects.
In flow chemistry reactions are performed in a reactor with the reactants pumped through it. It has the benefit of being easily scaled up and it is straightforward to integrate synthesis, workup and analysis into one system. This volume provides an update on recent advances in the field of flow chemistry, with special emphasis on new, integrated approaches for green and efficient chemistry. This book is a valuable resource for researchers in green chemistry, chemical engineers and Industrial chemists working in the pharmaceutical and fine chemicals industries.