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The class of plant-derived compounds known as saponins contain some moieties that have potential as vaccine adjuvants, most notably those originating from Quillaja saponaria Molina are potent immunostimulants. Particularly a purified fraction known as QS-21 has been shown to be a potent adjuvant for cytotoxic T-lymphocyte (CTL) induction. Triterpenoid and steroidal glycosides bearing the trisaccharide moiety of Quillaja saponins have been revealed important in immune responses, viral and bacterial infections, inflammation and many other inter and intracellular transductions. Some non-Quillaja saponins containing distinct aglycone moieties showed to be potent immunomodulators when administered together with alum for increasing immune responses in mammals and to be suitable for veterinary and human vaccines. In order to find new biologically active compounds for application in subunit vaccines and to investigate the structure-activity correlation, glycyrrhetic acid and friedelanol triterpenes were chosen as the aglycone moieties. Besides immunoadjuvanticity, other biological activities of interest could possibly be found in compounds bearing the aglycones glycyrrhetic acid and friedelanol, since some of their derivatives are known to have cytoprotective effects on carbon tetrachloride-induced hepatic injury or to be inhibitors of human lymphocyte proliferation and growth of human cancer cell lines in vitro. The biological properties previously mentioned as well as the adjuvant properties found for triterpenoid trisaccharide saponins, make the trisaccharide glycyrrhetic acid and friedelanol saponins interesting target molecules from a biological point of view, and therefore their syntheses are here described. Furthermore, a gypsogenin perbenzylated trisaccharide building block should be synthesized in order to provide a milestone for the total synthesis of QS-21 and analogs.
This collection seeks to elucidate the practical methods necessary for successful adjuvant development, with a particular focus on the synthesis, formulation, manufacturing, and characterization aspects involved. Beginning with an overview and a case study, the book then delves into in silico design, chemical synthesis, biosynthesis, and/or purification from natural raw materials of specific adjuvant molecules, adjuvant formulation approaches, the analytical characterization of adjuvant formulations and adjuvant-containing vaccines, as well as the biological characterization of vaccine adjuvant activity, including in vitro and in vivo approaches, to measure innate and adaptive immune responses. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Vaccine Adjuvants: Methods and Protocols aims to facilitate vaccine adjuvant product development efforts, making them more accessible, manufacturable, and better characterized.
Saponins are glycosides of triterpenes, steroids or steroidal alkaloids. They can be found in plants and marine organisms. Very diverse biological activities are ascribed to saponins and they play important roles in food, animal feedstuffs, and pharmaceutical properties. This volume provides a selection of recent work on saponins presented at a symposium in Pulawy, Poland, in 1999. Many different aspects are treated: analysis, separation, biological activities, relevant use in human and animal nutrition, and ecological significance. This book will be of use to researchers both in universities and industry.
''A wealth of information...these two volumes will be immensely valuable to anyone having to deal with this difficult group of compounds.'' ---Biochemical Systematics and Ecology, from a review of Saponins Used in Traditional and Modern Medicine and Saponins Used in Food and Agriculture
This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization
Most modern surfactants are readily biodegradable and exhibit low toxicity in the aquatic environment, the two criteria for green surfactants. However the majority are synthesised from petroleum, so over the past decade the detergent industry has turned its attention to developing greener routes to create these surfactants via renewable building blocks. Surfactants from Renewable Resources presents the latest research and commercial applications in the emerging field of sustainable surfactant chemistry, with emphasis on production technology, surface chemical properties, biodegradability, ecotoxicity, market trends, economic viability and life-cycle analysis. Reviewing traditional sources for renewable surfactants as well as recent advances, this text focuses on techniques with potential for large scale application. Topics covered include: Renewable hydrophobes from natural fatty acids and forest industry by-products Renewable hydrophiles from carbohydrates, amino acids and lactic acid New ways of making renewable building blocks; ethylene from renewable resources and complex mixtures from waste biomass Biosurfactants Surface active polymers This book is a valuable resource for industrial researchers in companies that produce and use surfactants, as well as academic researchers in surface and polymer chemistry, sustainable chemistry and chemical engineering.
''A wealth of information...these two volumes will be immensely valuable to anyone having to deal with this difficult group of compounds.'' ---Biochemical Systematics and Ecology, from a review of Saponins Used in Traditional and Modern Medicine and Saponins Used in Food and Agriculture ''A valuable contribution to the literature.'' ---The Quarterly Review of Biology, December 1997
This volume, as the seventh of the series Medicinal and Aromatic Plants of the World, deals with the medicinal and aromatic plant (MAPs) treasures of the so-called Southern Cone, the three southernmost countries (Argentina, Chile and Uruguay) of South America. Similarly to the previous volumes of the series, the main focus is to collect and provide information on major aspects of botany, traditional usage, chemistry, production / collection practices, trade and utilization of this specific group of plants. The contributors, who are recognized professionals and specialist of the domain, have collected and present state of the art information on 41 species. Most of these are not only of interest from the scientific point of view, but hold also a potential for the prospective utilization of the decreasing, occasionally overexploited / endangered medicinal plant resources of this huge continent. The book is expected to serve as a source of information also on some less known or less studied species. As such the volume is expected to support future research and public health professionals.