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Cellular Dynamics of the Neuron covers advances in the study of the cellular dynamics of the neuron. The book discusses the synthesis and transport of the neuroplasm, as well as the synthesis, transport, and action of neurotransmitters. The text also describes the functional implications of synaptic ultrastructure and the morphological and biochemical correlates of neuronal plasticity. Cell biologists, neurobiologists, cell pathologists, molecular biologists, and physiologists will find the book invaluable.
Advances in axon biology are so rapid that every year provides us with a wealth of new facts and observations; hence, this conference cannot reasonable be expected to answer all questions. Rather, its purpose must be to take stock of the available data, to communicate advances and new concepts, and to help us to formulate the goals and approaches for future research. To this end, ample time was allotted during the symposium for discussion, but these exchanges of thoughts cannot, unfortunately, be included in the printed text. We hope that publication of the presentations will provide a valuable source of information on the present state of knowledge on this most important borderland between neuro pathology, neurophysiology and neurochemistry. We would like to express our gratitude to all participants of the symposium for contributing their efforts and for their enthusiasm. We are also indebted to Springer Verlag and Bergmann Verlag for publication of the symposium and for their appreciation of the editorial concerns.
Dynamics of Degeneration and Growth in Neurons is a collection of papers presented at the International Symposium on the Dynamics of Degeneration and Growth in Neurons, held in Stockholm, Sweden, on May 16-18, 1973. Contributors explore the dynamics of degeneration and growth of central and peripheral neurons, touching on a wide range of topics such as the neurotoxic action of 6-hydroxy-dopa on central catecholamine neurons; axonal transport of proteins in growing and regenerating neurons; and collateral reinnervation in the central nervous system. Comprised of 50 chapters, this volume begins with an overview of degeneration processes in central and peripheral neurons. Results of microfluorimetric and neurochemical studies on degenerating and regenerating adrenergic nerves are presented. The next section is devoted to axoplasmic transport as a mechanism for axonal support and growth and includes chapters dealing with the effects of degeneration and axoplasmic transport blockade on synaptic ultrastructure, function, and protein composition; the role of axoplasmic flow in trophism of skeletal muscle; and proximodistal transport of acetylcholine in peripheral cholinergic neurons. The remaining chapters discuss the nerve growth factor receptor and its specific binding in sympathetic ganglia; the noradrenergic innervation of cerebellar Purkinje cells; and the possible role of brain and peripheral monoamines in the ontogenesis of normal and drug-induced responses in the immature mammal. This book will be of interest to physiologists and neurologists.
To commemorate properly the 70th birthday of a man who, by his very nature, is too busy to pause for any kind of ceremonial event unless it has a concomitant functional output was a difficult problem for the Staff and Associates of the Neurosciences Research Program. Frank (F. O. S. ) has always dreaded the prospect that sometime it might be appropriate for his colleagues to present him a Fest schrift. In fact, "Fest me no Schriften" became his battle cry, expressing his feeling that the idea of testimonials clustered into a book was anathema. So the "break through" idea for the planners was to organize a symposium around the theme of discovery in neuroscience that would be valuable scientifically and, in its demon stration of interdisciplinary interaction, would support that emphasis in Frank's career. After much planning a program was developed, beginning with a birthday party the evening before, followed by the two-day symposium, and closing with the first F. O. Schmitt Lecture in Neuroscience. We hope that publication of the scientific proceedings in this volume will be of interest not only to the neuroscience community, but also to a broad general readership interested in discovery, under standing, and the creative processes in scientific work. An organizing committee, chaired by Fred Worden, collected advice and guidance leading to the selection of speakers whose scientific careers have played an important part in the recent history of modern neuroscience.
Behavioral Embryology deals with the theoretical, philosophical, and empirical problems of behavioral embryology. The book is composed of studies on prenatal neural and behavioral development. The text discussed various topics on behavioral embryology such as the genetic aspects of neuro-embryology; prenatal ""organizing"" effect of gonadal hormones on the brain and later behavior; sensory, motor, or central neural function; overt embryonic or fetal sensitivity; and overt motility and actual behavior. Embryologists, anatomists, cell biologists, physiologists, physicians, and medical researchers will find the book invaluable.
This volume was first published in 1980, it is a comprehensive treatment of coated vesicles and their involvement in the process of endocytosis.
The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.