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Survival, the IISS’s bimonthly journal, challenges conventional wisdom and brings fresh, often controversial, perspectives on strategic issues of the moment. In this issue: · The Ukraine crisis: Robert Hunter argues that the most important requirement of successful US-led negotiations with Russia is that Moscow demonstrate that it is prepared to be a responsible international actor · Erin Sikorsky contends that climate change should have a larger role in the day-to-day national-security agendas of the United States and other countries · Stephan Frühling and Andrew O’Neil warn that current US debates about no first use tend to underplay the broader alliance implications of any shift in US nuclear policy · Rahul Roy-Chaudhury and Kate Sullivan de Estrada assess that, given the 2021 US FONOP targeting India, Washington and New Delhi need to better manage their diverse positions on global governance, especially in the maritime domain · Nien-chung Chang-Liao warns that pragmatism in Chinese foreign policy is waning and considers why Chinese diplomats have become so aggressive And nine more thought-provoking pieces, as well as our regular Book Reviews and Noteworthy column. Editor: Dr Dana Allin Managing Editor: Jonathan Stevenson Associate Editor: Carolyn West Assistant Editor: Jessica Watson
Survival, the IISS’s bimonthly journal, challenges conventional wisdom and brings fresh, often controversial, perspectives on strategic issues of the moment. In this issue: Franz-Stefan Gady and Michael Kofman highlight the pitfalls of grafting a Western manoeuvre-oriented approach to war onto the Russia–Ukraine conflict Irene Mia examines the chasm between Javier Milei’s dramatic rhetoric and the domestic and international obstacles he faces to changing Argentina’s foreign and economic policies Edoardo Campanella and John Haigh outline the necessity of meaningful dialogue between the West and China to prevent the internet’s fragmentation John Raine assesses the geopolitical trends that the Gaza war has set in motion and the issues they create for Ukraine’s defence against Russia And seven more thought-provoking pieces, as well as our regular Book Reviews and Noteworthy column. Editor: Dr Dana Allin Managing Editor: Jonathan Stevenson Associate Editor: Carolyn West Editorial Assistant: Conor Hodges
Published each year since 1959, The Military Balance is an indispensable reference to the capabilities of armed forces across the globe. It is used by academia, the media, armed forces, the private sector and government. It is an open-source assessment of the military forces and equipment inventories of 171 countries, with accompanying defence economics and procurement data. Alongside detailed country data, The Military Balance assesses important defence issues, by region, as well as key global trends, such as in defence technology and equipment modernisation. This analysis is accompanied by full-colour graphics, including maps and illustrations. With extensive explanatory notes and reference information, The Military Balance is as straightforward to use as it is extensive. The 2022 edition is accompanied by a fullcolour wall chart illustrating security dynamics in the Arctic.
Precision medicine is the main emphasis in healthcare after recognizing the importance to integrate the clinical data with the molecular data of a specific disease. The term was first introduced in 2015 in which the Precision Medicine Initiative was initiated with the final aim to provide targeted therapy with high efficacy and less toxicity. Precision medicine plays an increasingly important in gastrointestinal cancers. Gastrointestinal cancers are divided into the upper (esophagus, stomach) and lower part (hepatobiliary and colon) of the gastrointestinal system. We would like to explore the latest era of integrative therapeutic target in gastrointestinal cancers taking into consideration of various aetiologies including genetic and exposome (dietary factors, microbial, hormonal, environmental insults) and their interactions with the host microenvironment.
In the last couple of decades, the study of the cancer genome and the progressive implementation of next-generation sequencing platforms have provided the Scientific and Oncology communities with a multitude of data, technologies, diagnostic, prognostic, and predictive tools that have been revolutionizing the way we can study, diagnose and treat cancer, including breast tumors. For example, genomic tests can now refine the prognosis of early-stage breast cancer patients beyond standard clinicopathological features and help guide escalated or de-escalated treatment choices. The identification of the molecular intrinsic subtypes might also be helpful in guiding treatment choices in advanced hormone receptor-positive disease. The identification of germline mutations in BRCA1 or BRCA2 has led to the development and introduction of PARP inhibitors for the treatment of advanced and early-stage breast cancer, along with personalized follow-up and prophylactic surgical procedures for patients with or without cancer, carrying such mutations.
- NEW! Updated content throughout reflects the 2022 OCN® Examination blueprint, along with the latest national and international guidelines and the most current research evidence. - NEW! A Myelofibrosis chapter is added to address this important cancer type, and a Social Determinants of Health and Financial Toxicity chapter addresses the cost of cancer treatment and financial burden of cancer treatment on patients and families. - NEW! COVID-19–related content reflects the impact of the ongoing pandemic, including differential diagnoses for pulmonary symptoms and the impact of delayed cancer diagnosis and treatment. - NEW! Updated emphases mirror those of the American Association of Colleges of Nursing 2021 Essentials as well as the recommendations of the 2020-2030 Future of Nursing report.