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A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.
Walter Isaacson’s #1 New York Times bestselling history of our third scientific revolution: CRISPR, gene editing, and the quest to understand the code of life itself, is now adapted for young readers! When Jennifer Doudna was a sixth grader in Hilo, Hawaii, she came home from school one afternoon and found a book on her bed. It was The Double Helix, James Watson’s account of how he and Francis Crick had discovered the structure of DNA, the spiral-staircase molecule that carries the genetic instruction code for all forms of life. This book guided Jennifer Doudna to focus her studies not on DNA, but on what seemed to take a backseat in biochemistry: figuring out the structure of RNA, a closely related molecule that enables the genetic instructions coded in DNA to express themselves. Doudna became an expert in determining the shapes and structures of these RNA molecules—an expertise that led her to develop a revolutionary new technique that could edit human genes. Today gene-editing technologies such as CRISPR are already being used to eliminate simple genetic defects that cause disorders such as Tay-Sachs and sickle cell anemia. For now, however, Jennifer and her team are being deployed against our most immediate threat—the coronavirus—and you have just been given a front row seat to that race.
One of America's most versatile writers, author of bestselling biographies such as Steve Jobs and Benjamin Franklin, has assembled a gallery of portraits of (mostly) Americans that celebreate genius, talent, and versatility, and traces his own education as a writer and biographer. In this collection of essays, the brilliant, acclaimed biographer Walter Isaacson reflects on lessons to be learned from Benjamin Franklin, Albert Einstein, Bill Gates, Henry Kissinger, Ronald Reagan and Mikhail Gorbachev, Hillary Clinton and Bill Clinton, and other interesting characters he has chronicled both as biographer and journalist. The people he writes about have an awesome intelligence, but that is not the secret to their success. They had qualities that were even more rare, such as imagination and true curiousity. Isaacson also reflects on how he became a writer, the lessons he learned from various people he met, and the challenges for journalism in the digital age. He also offers loving tributes to his hometown of New Orleans, which offers many of the ingredients for a creative culture, and to the Louisiana novelist Walker Percy, who was an early mentor. In an anecdotal and personal way, Isaacson describes the joys of writing and the way that tales about the lives of fascinating people can enlighten our own lives.
A Best Book of the YearSeed Magazine • Granta Magazine • The Plain-DealerIn this fascinating and utterly engaging book, Carl Zimmer traces E. coli's pivotal role in the history of biology, from the discovery of DNA to the latest advances in biotechnology. He reveals the many surprising and alarming parallels between E. coli's life and our own. And he describes how E. coli changes in real time, revealing billions of years of history encoded within its genome. E. coli is also the most engineered species on Earth, and as scientists retool this microbe to produce life-saving drugs and clean fuel, they are discovering just how far the definition of life can be stretched.
This exclusive boxed set from beloved New York Times bestselling author Walter Isaacson features his definitive biographies: Steve Jobs, Einstein, Benjamin Franklin, and Leonardo da Vinci. “If anybody in America understands genius, it’s Walter Isaacson.” —Salon Celebrated historian, journalist, and bestselling author Walter Isaacson’s biography collection of geniuses now available in one boxed set—the perfect gift for history lovers everywhere. Steve Jobs: The “enthralling” (The New Yorker) worldwide bestselling biography of legendary Apple cofounder Steve Jobs. The story of the roller-coaster life and intense creative entrepreneur whose passion for perfection and ferocious drive revolutionized six industries: personal computers, animated movies, music, phones, tablet computing, and digital publishing. Isaacson’s portrait touched millions of readers. Einstein: How did his mind work? What made him a genius? Isaacson’s biography of Albert Einstein—also the basis for the ten-part National Geographic series starring Geoffrey Rush—shows how Einstein’s scientific imagination sprang from the rebellious nature of his personality. His fascinating story is a testament to the connection between creativity and freedom. Benjamin Franklin: In this colorful and intimate narrative, Isaacson provides the full sweep of Ben Franklin’s amazing life, showing how the most fascinating Founding Father helped forge the American national identity. Leonardo da Vinci: History’s consummate innovator and most creative thinker. Isaacson illustrates how Leonardo’s genius was based on skills we can improve in ourselves, such as passionate curiosity, careful observation, and an imagination so playful that it flirted with fantasy.
Chronicles the lives and careers of the men and women responsible for the creation of the digital age, including Doug Englebart, Robert Noyce, Bill Gates, Steve Jobs and more.
Based on more than 40 interviews with Jobs conducted over two years--as well as interviews with more than 100 family members, friends, adversaries, competitors, and colleagues--Isaacson has written a riveting story of the roller-coaster life and searingly intense personality of a creative entrepreneur whose passion for perfection and ferocious drive revolutionized six industries: personal computers, animated movies, music, phones, tablet computing, and digital publishing.
A captivating blend of personal biography and public drama, The Wise Men introduces the original best and brightest, leaders whose outsized personalities and actions brought order to postwar chaos: Averell Harriman, the freewheeling diplomat and Roosevelt's special envoy to Churchill and Stalin; Dean Acheson, the secretary of state who was more responsible for the Truman Doctrine than Truman and for the Marshall Plan than General Marshall; George Kennan, self-cast outsider and intellectual darling of the Washington elite; Robert Lovett, assistant secretary of war, undersecretary of state, and secretary of defense throughout the formative years of the Cold War; John McCloy, one of the nation's most influential private citizens; and Charles Bohlen, adroit diplomat and ambassador to the Soviet Union.
NOW A MAJOR SERIES 'GENIUS' ON NATIONAL GEOGRAPHIC, PRODUCED BY RON HOWARD AND STARRING GEOFFREY RUSH Einstein is the great icon of our age: the kindly refugee from oppression whose wild halo of hair, twinkling eyes, engaging humanity and extraordinary brilliance made his face a symbol and his name a synonym for genius. He was a rebel and nonconformist from boyhood days. His character, creativity and imagination were related, and they drove both his life and his science. In this marvellously clear and accessible narrative, Walter Isaacson explains how his mind worked and the mysteries of the universe that he discovered. Einstein's success came from questioning conventional wisdom and marvelling at mysteries that struck others as mundane. This led him to embrace a worldview based on respect for free spirits and free individuals. All of which helped make Einstein into a rebel but with a reverence for the harmony of nature, one with just the right blend of imagination and wisdom to transform our understanding of the universe. This new biography, the first since all of Einstein's papers have become available, is the fullest picture yet of one of the key figures of the twentieth century. This is the first full biography of Albert Einstein since all of his papers have become available -- a fully realised portrait of this extraordinary human being, and great genius. Praise for EINSTEIN by Walter Isaacson:- 'YOU REALLY MUST READ THIS.' Sunday Times 'As pithy as Einstein himself.’ New Scientist ‘[A] brilliant biography, rich with newly available archival material.’ Literary Review ‘Beautifully written, it renders the physics understandable.’ Sunday Telegraph ‘Isaacson is excellent at explaining the science. ' Daily Express
What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us? In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos—as dramatic a development in genetics as the 1996 cloning of Dolly the sheep. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention. The two babies, nonidentical twin girls, were the first “CRISPR'd” people ever born (CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing method). Greely not only describes He's experiment and its public rollout (aided by a public relations adviser) but also considers, in a balanced and thoughtful way, the lessons to be drawn both from these CRISPR'd babies and, more broadly, from this kind of human DNA editing—“germline editing” that can be passed on from one generation to the next. Greely doesn't mince words, describing He's experiment as grossly reckless, irresponsible, immoral, and illegal. Although he sees no inherent or unmanageable barriers to human germline editing, he also sees very few good uses for it—other, less risky, technologies can achieve the same benefits. We should consider the implications carefully before we proceed.