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Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals
This neuroanatomy text is specifically tailored to the needs of students in Communication Sciences and Disorders. It includes foundational knowledge of general neuroanatomy with a focus on neuroanatomy that is relevant to speech language pathology and audiology. This accessible text introduces students to neuroanatomy with excellent organization of important topics such as, key information on the neurology of: language, speech, hearing, swallowing, cognition, and emotion. The chapter on emotion will be especially relevant to those working with clients with autism spectrum disorders. Neuroanatomy for Speech Language Pathology and Audiology will help students meet ASHA's Knowledge and Skills Acquisition learning outcome IIIB, which states: 'Student will demonstrate knowledge of basic human communication and swallowing processes, including their biological, neurological, acoustical, cultural, and developmental bases.
Representing what someone else has said is an integral part of spoken and written communication. Speech representation occurs in many contexts from news reports and legal trials to everyday conversation. Although commonplace, it requires sophisticated choices regarding what to represent and how to represent it. These choices can highlight a speaker's voice, shape our perception of the reported speech, or support our claims of authority.While speech representation in Present-day English has been studied extensively, this book extends the discussion to historical periods. Speech Representation in the History of English explores speech representation of the past, providing in-depth analyses of how speakers and writers mark, structure, and discuss a previous speech event or fictional speech. Focusing on the Early Modern English and the Late Modern English periods (1500-1900), this volume covers topics such as parentheses as markers of represented speech, the development of like as a reporting expression, the gradual formation of free indirect speech reporting, and the interpersonal functions of represented speech. Chapters draw on a wide range of methodologies, including historical sociolinguistics, pragmatics, and corpus linguistics, and cover many genres from witness depositions, literary texts, and letters, to the spoken language of the recent past. In this comprehensive volume, Peter Grund and Terry Walker bring together a collection of works that use cutting-edge approaches to speech representation. Researchers and students of the history of English, sociolinguistics, and discourse studies alike will find Speech Representation in the History of English to be an invaluable addition to the field.