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The advancement of semiconductor technology has popularized the low power, economical and small form-factor solid state devices, such as those highly integrated and interconnected as the fundamental infrastructure for the internet of things (IoT). Due to its CMOS-compatibility and electrical interface, the biosensor utilizing field effect transistor (FET) as transducer has become the perfect candidate to interface directly with the chemical and biological properties of the physical world. Especially, nanowire (NW) FET biosensor has received great attention as a highly sensitive biosensing platform, benefiting from its increased surface-to-volume ratio. In this work, several challenges and key aspects of existing NW FET biosensor were studied, and solutions were proposed to address these problems. For example, the hydrolytic stability of the surface sensing element was evaluated and improved by a hydrolysis process, which led to a significant increase in the overall biosensor performance. Another challenge is the noise in the electric potential of the sensing solutions. A secondary reference electrode was introduced in the biosensing system, and its potential was used to subtract the noise from the measured sensor output. Compared to a reference FET, this approach greatly reduced the system complexity and requirement, yet still improved the limit of detection (LOD) by 50 – 70%. This work also involved careful investigation into the analyte sensitivity, which can be considerably affected by the charge buffering effect from the surface hydroxyl groups. Analytical studies and numerical simulations were carried out, revealing that both low pH sensitivity and large analyte buffer capacity are required to achieve a reasonable analyte sensitivity. The most significant portion of this work was the experimental demonstration of the digital biosensing concept with single serpentine NW FET biosensor. The majority of existing FET biosensors utilized the device as an analog transducer, which measures the captured analyte density to generate an output, and suffers from various noise factors, especially the nonspecific changes of the sensing solutions than cannot be reduced by averaging. Digital biosensor no longer depends on the amplitude of the sensor output and is therefore better immune from these noise factors. Instead, the individual binding event of single analyte is counted and analyzed statistically to determine the analyte concentration. The single serpentine NW FET is the ideal device design to achieve digital biosensing. It maintains the low noise level with the equivalently long channel, yet achieves a small footprint enough for binding of only a single analyte. The binding of analyte to multiple segments of the NW results in both higher sensitivity and binding avidity. The small footprint also enables high integration density of the individual digital biosensors into an array format, which is a responsive, highly sensitive, and cost-effective future biosensing platform.
“Nanowire Field Effect Transistor: Basic Principles and Applications” places an emphasis on the application aspects of nanowire field effect transistors (NWFET). Device physics and electronics are discussed in a compact manner, together with the p-n junction diode and MOSFET, the former as an essential element in NWFET and the latter as a general background of the FET. During this discussion, the photo-diode, solar cell, LED, LD, DRAM, flash EEPROM and sensors are highlighted to pave the way for similar applications of NWFET. Modeling is discussed in close analogy and comparison with MOSFETs. Contributors focus on processing, electrostatic discharge (ESD) and application of NWFET. This includes coverage of solar and memory cells, biological and chemical sensors, displays and atomic scale light emitting diodes. Appropriate for scientists and engineers interested in acquiring a working knowledge of NWFET as well as graduate students specializing in this subject.
Advanced Field-Effect Transistors: Theory and Applications offers a fresh perspective on the design and analysis of advanced field-effect transistor (FET) devices and their applications. The text emphasizes both fundamental and new paradigms that are essential for upcoming advancement in the field of transistors beyond complementary metal–oxide–semiconductors (CMOS). This book uses lucid, intuitive language to gradually increase the comprehension of readers about the key concepts of FETs, including their theory and applications. In order to improve readers’ learning opportunities, Advanced Field-Effect Transistors: Theory and Applications presents a wide range of crucial topics: Design and challenges in tunneling FETs Various modeling approaches for FETs Study of organic thin-film transistors Biosensing applications of FETs Implementation of memory and logic gates with FETs The advent of low-power semiconductor devices and related implications for upcoming technology nodes provide valuable insight into low-power devices and their applicability in wireless, biosensing, and circuit aspects. As a result, researchers are constantly looking for new semiconductor devices to meet consumer demand. This book gives more details about all aspects of the low-power technology, including ongoing and prospective circumstances with fundamentals of FET devices as well as sophisticated low-power applications.
In its second, extensively revised second edition, Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and biomedical applications of this key material. The book begins by reviewing the basics of growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires. Attention then turns to use of these structures for tissue engineering and delivery applications, followed by detection and sensing. Reflecting the evolution of this multidisciplinary subject, several new key topics are highlighted, including our understanding of the cell-nanowire interface, latest advances in associated morphologies (including silicon nanoneedles and nanotubes for therapeutic delivery), and significantly, the status of silicon nanowire commercialization in biotechnology. Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and the next generation of nano-biotech platforms that require a detailed understanding of the cell-nanowire interface, along with researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive structures. Reviews the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires Describes silicon nanowires for tissue engineering and delivery applications, including cellular binding & internalization, tissue engineering scaffolds, mediated differentiation of stem cells, and silicon nanoneedles & nanotubes for delivery of small molecule / biologic-based therapeutics Highlights the use of silicon nanowires for detection and sensing Presents a detailed description of our current understanding of the cell-nanowire interface Covers the current status of commercial development of silicon nanowire-based platforms
This book describes the n and p-channel Silicon Nanowire Transistor (SNT) designs with single and dual-work functions, emphasizing low static and dynamic power consumption. The authors describe a process flow for fabrication and generate SPICE models for building various digital and analog circuits. These include an SRAM, a baseband spread spectrum transmitter, a neuron cell and a Field Programmable Gate Array (FPGA) platform in the digital domain, as well as high bandwidth single-stage and operational amplifiers, RF communication circuits in the analog domain, in order to show this technology’s true potential for the next generation VLSI.
Abstract Silicon planar MOSFETs are approaching their scaling limits. New device designs are being explored to replace the existing planar technology. Among the possible new device designs are Double Gate (DG) FETs, FinFETs, Tri-Gate FETs and Omega- Gate FETs. The Silicon Nanowire Gate All Around (GAA) FET stands out as one of the most promising FET designs due to its maximum gate effect in controlling the short channel effects. Recent developments such as synthesis of highly ordered nanowires and fabrication of nanowires as small as 1nm in diameter have illustrated the progress possible in silicon nanowire technology In this study we have explored the silicon nanowire FET as a possible candidate to replace the currently planar MOSFETs. In this thesis we investigated the silicon nanowire FET device and compared its performance with that of a double gate (DG) FET. The software used for the study assumed quantum-ballistic transport (NanoWire), which was developed at Purdue University. Initially, we presented a comparison of Nanowire FET with DG FET with for devices with same physical parameters. It was seen that superior subthreshold characteristics are exhibited by a silicon nanowire FET. We also conducted an optimization study for the 25 nm node from the ITRS report. The final device was optimized for both High Performance and Low Operating Power applications. A further study on future technology nodes down to the 14 nm node was performed which revealed short channel effects becomes significant at gate lengths ~ 5 nm even for a silicon nanowire device. Finally, a process variation study was conducted in comparison with a FinFET device. It was concluded that a silicon nanowire FET shows less sensitivity to process variation except it has higher sensitivity in variation with the diameter at less than ~4 nm than for FinFET where significant quantum effects set in. Variation with the gate length was found to be much less sensitive for the silicon nanowire FET because of its superior gate control characteristics.