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This is a comprehensive treatment of the field of SPR sensors, in three parts. Part I introduces principles of surface plasmon resonance bio-sensors, electromagnetic theory of surface plasmons, theory of SPR sensors and molecular interactions at sensor surfaces. Part II examines the development of SPR sensor instrumentation and functionalization methods. Part III reviews applications of SPR biosensors in the study of molecules, and in environmental monitoring, food safety and medical diagnostics.
This significantly extended second edition addresses the important physical phenomenon of Surface Plasmon Resonance (SPR) or Surface Plasmon Polaritons (SPP) in thin metal films, a phenomenon which is exploited in the design of a large variety of physico-chemical optical sensors. In this treatment, crucial materials aspects for design and optimization of SPR sensors are investigated and described in detail. The text covers a selection of nanometer thin metal films, ranging from free-electron to the platinum-type conductors, along with their combination with a large variety of dielectric substrate materials, and associated individual layer and opto-geometric arrangements. Whereas the first edition treated solely the metal-liquid interface, the SP-resonance conditions considered here are expanded to cover the metal-gas interface in the angular and wavelength interrogation modes, localized and long-range SP's and the influence of native oxidic ad-layers in the case of non-noble metals. Furthermore, a selection of metal grating structures that allow SP excitation is presented, as are features of radiative SP's. Finally, this treatise includes as-yet hardly explored SPR features of selected metal–metal and metal–dielectric superlattices. An in-depth multilayer Fresnel evaluation provides the mathematical tool for this optical analysis, which otherwise relies solely on experimentally determined electro-optical materials parameters.
This book addresses the important physical phenomenon of Surface Plasmon Resonance or Surface Plasmon Polaritons in thin metal films, a phenomenon which is exploited in the design of a large variety of physico-chemical optical sensors. In this treatment, crucial materials aspects for design and optimization of SPR sensors are investigated and outlined in detail. The text covers the selection of nanometer thin metal films, ranging from free-electron to the platinum type conductors, along with their combination with a large variety of dielectric substrate materials, and associated individual layer and opto-geometric arrangements. Furthermore, as-yet hardly explored SPR features of selected metal–metal and metal–dielectric super lattices are included in this report. An in-depth multilayer Fresnel evaluation provides the mathematical tool for this optical analysis, which otherwise relies solely on experimentally determined electro-optical materials parameters.
2D Materials for Surface Plasmon Resonance-based Sensors offers comprehensive coverage of recent design and development (including processing and fabrication) of 2D materials in the context of plasmonic-based devices. It provides a thorough overview of the basic principles and techniques used in the analysis and design of 2D material-based optical sensor systems. Beginning with the basic concepts of plasmon/plasmonic sensors and mathematical modelling, the authors explain the fundamental properties of 2D materials, including Black Phosphorus (BP), Phosphorene, Graphene, Transition metal dichalcogenides (TMDCs), MXene's and SW-CNT. It also details the applications of these emerging materials in clinical diagnosis and their future trends. This text will be useful for practising engineers, undergraduate and postgraduate students. Key Features Presents the fundamental concepts of 2D material assisted fibre optic and prism based SPR sensor in a student-friendly manner. Includes the recent synthesis and characterization techniques of 2D materials. Provides computational results of recently discovered electronic and optical properties of the 2D materials along with their effectiveness in the field of plasmonic sensors. Presents emerging applications of novel 2D material-based plasmonic sensors in the field of chemical, bio-chemical and biosensing.
Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events, this book provides a total system description including optics, fluidics and sensor surfaces for a wide researcher audience.
In the last two decades, the unusual optical and physical properties of novel metallic nanostructures (such as gold, silver, and aluminum) has been the subject of intense research efforts. Surface plasmon resonance and localized surface plasmon resonance are two of the unique phenomena in novel metals which can be used to create different kinds of sensitive sensors and biosensors. In this work, a refractive index sensor based on surface plasmon resonance is designed and analytically investigated by a finite element method via COMSOL Multiphysics to detect chemicals. The intensity, spectral width and sensitivity of the plasmonic signals are highly affected by the shape, size, and configuration of the metallic nanostructures. Patterning the planar metallic thin film with cavities or protrusion can result in obtaining a tunable sensitivity for the sensor. The architecture of the nanohole/nanowire arrays leads to a nanostructure having multiple plasmonics properties. The simulation results show that the co-excitation of surface plasmon resonance and localized surface plasmon resonance modes can enhance the sensitivity of the SPR-based sensors significantly. To obtain this result, several cut lines through the metallic thin film were considered and the variation of the electric field intensity along those cut lines is studied. To determine the SPR and LSPR modes, the penetration depth of the plasmon field is characterized at metal/dielectric interfaces. After investigation of three models for the metallic layer (planar thin film, nanohole patterned thin film, and protrusive thin film), it was concluded that the device made of 20 nm cylindrical nanowire supported by a 40 nm thin film can result in the best performance parameters (in terms of sensitivity, absorption, and accuracy). Eight substances with refractive indices ranging from 1.333 to 1.38 were used to obtain the calibration data of the optimum sensor. The linear characteristic of the calibration curve shows that the sensor is able to detect unknown materials as a function of resonance wavelength. This study is proposing a new way to show the duality nature of patterned thin films to support both propagating and localized surface plasmon modes.
This book focuses on the surface plasmon resonance (SPR) technique covering fibre optic sensor research. It highlights recent advancements in geometric feature-based fibre optic SPR sensors for chemical/biochemical/biosensor applications. The contents also discuss the principle of the SPR sensing technique as well as various designs of fibre optic SPR probes for improving sensor sensitivity. It also includes numerous examples of SPR-based fibre optic sensors with various geometric (such as U-type, taper type, D-type, and interferometric-based) sensors. This volume will be a useful reference to those in academia and industry especially researchers with useful information focusing on fibre optic SPR sensors.
Surface Plasmon Resonance in Bioanalysis, Volume 95 in the Comprehensive Analytical Chemistry series, contains a wide range of topics on the applications and new advances of surface plasmon resonance (SPR) in bioanalysis, including Surface plasmon resonance microscopy for single-cell based drug screening, Phase-Sensitive Surface Plasmon Resonance Sensors for Highly Sensitive Bioanalysis, SPR coupled to ambient mass spectrometry, Surface Plasmon Resonance Microscopy for activity detection and imaging of single cells, SPR for water pollutant detection and biofouling control, SPR imaging for cellular analysis and detection, Progress in detection of surface palsmon resonance for biorefinery technology, and more. Additional chapters cover Long-range surface plasmon resonance and its biological sensing applications and Critical issues in clinical and biomedical applications of Surface Plasmon Resonance sensing. Provides updates on the latest applications of SPR microscopy in cell analysis Covers the latest design in SPR sensing for highly sensitive bioanalysis Presents the critical issues in clinical and biomedical applications of SPR
Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events. This book focuses on a total system description including optics, fluidics and sensor surfaces. It covers all commercial SPR systems in the market. It is the first of its kind and fills a gap in the technical literature as no other handbook on SPR is currently available. The final chapter discussed new trends and a vision is given for future developments and needs of the SPR market. This excellent handbook provides comprehensive information with easy to use, stand-alone chapters and will be of great use to anyone one working with or affiliated to the technology.