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Links complete solutions to all odd-numbered exercises with additional notes guiding the student; thus provides the functions of a solutions manual and of a study guide, focusing on understanding of concepts and not only on mechanics.
Contains fully worked solutions to all odd-numbered exercises in the text.
Take Your NI Trial to the Next Level Reflecting the vast research on noninferiority (NI) designs from the past 15 years, Noninferiority Testing in Clinical Trials: Issues and Challenges explains how to choose the NI margin as a small fraction of the therapeutic effect of the active control in a clinical trial. Requiring no prior knowledge of NI testing, the book is easily accessible to both statisticians and nonstatisticians involved in drug development. With over 20 years of experience in this area, the author introduces the basic elements of the NI trials one at a time in a logical order. He discusses issues with estimating the effect size based on historical placebo control trials of the active control. The book covers fundamental concepts related to NI trials, such as assay sensitivity, constancy assumption, discounting, and preservation. It also describes patient populations, three-arm trials, and the equivalence of three or more groups.
In the summer of 1966 Norman Leigh took a team to the Casino Municipal in Nice with the express intention of systematically winning large sums of money at roulette. Two weeks later the team was banned from every casino in France. Not for cheating, or rowdy behaviour - but for winning, methodically and consistently. An absolute classic detailing the events leading up to - and, most importantly, the system that allowed this to happen - an event held as impossible by all expert opinion - breaking the bank at roulette.