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The Committee on Dosimetry for the Radiation Effects Research Foundation (RERF) was set up more than a decade ago at the request of the U.S. Department of Energy. It was charged with monitoring work and experimental results related to the Dosimetry System 1986 (DS86) used by RERF to reconstruct the radiation doses to the survivors in Hiroshima and Nagasaki. At the time it was established, DS86 was believed to be the best available dosimetric system for RERF, but questions have persisted about some features, especially the estimates of neutrons resulting from the Hiroshima bomb. This book describes the current situation, the gamma-ray dosimetry, and such dosimetry issues as thermal-neutron discrepancies between measurement and calculation at various distances in Hiroshima and Nagasaki. It recommends approaches to bring those issues to closure and sets the stage for the recently convened U.S. and Japan Working Groups that will develop a new dosimetry for RERF. The book outlines the changes relating to DS86 in the past 15 years, such as improved numbers that go into, and are part of, more sophisticated calculations for determining the radiations from bombs that reach certain distances in air, and encourages incorporation of the changes into a revised dosimetry system.
The Committee on Dosimetry for the Radiation Effects Research Foundation (RERF) was set up more than a decade ago at the request of the U.S. Department of Energy. It was charged with monitoring work and experimental results related to the Dosimetry System 1986 (DS86) used by RERF to reconstruct the radiation doses to the survivors in Hiroshima and Nagasaki. At the time it was established, DS86 was believed to be the best available dosimetric system for RERF, but questions have persisted about some features, especially the estimates of neutrons resulting from the Hiroshima bomb. This book describes the current situation, the gamma-ray dosimetry, and such dosimetry issues as thermal-neutron discrepancies between measurement and calculation at various distances in Hiroshima and Nagasaki. It recommends approaches to bring those issues to closure and sets the stage for the recently convened U.S. and Japan Working Groups that will develop a new dosimetry for RERF. The book outlines the changes relating to DS86 in the past 15 years, such as improved numbers that go into, and are part of, more sophisticated calculations for determining the radiations from bombs that reach certain distances in air, and encourages incorporation of the changes into a revised dosimetry system.
Do persons exposed to radiation suffer genetic effects that threaten their yet-to-be-born children? Researchers are concluding that the genetic risks of radiation are less than previously thought. This finding is explored in this volume about the children of atomic bomb survivors in Hiroshima and Nagasakiâ€"the population that can provide the greatest insight into this critical issue. Assembled here for the first time are papers representing more than 40 years of research. These documents reveal key results related to radiation's effects on pregnancy termination, sex ratio, congenital defects, and early mortality of children. Edited by two of the principal architects of the studies, J. V. Neel and W. J. Schull, the volume also offers an important comparison with studies of the genetic effects of radiation on mice. The wealth of technical details will be immediately useful to geneticists and other specialists. Policymakers will be interested in the overall conclusions and discussion of future studies.
This book follows up a 2005 International Conference in Yerevan, Armenia dedicated to the 70th anniversary of the 1935 publication of the "green paper", by N.W. Timofeeff-Ressovsky, K. Zimmer and M. Delbruck entitled "On the origin of gene mutations and gene structure". This was the starting point of the NATO Advanced Research Workshop, whose proceedings are published in this book, with papers dealing directly with Timofeeff-Ressovsky’s life, and the "green pamphlet".
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
The Radiation Exposure Compensation Act (RECA) was set up by Congress in 1990 to compensate people who have been diagnosed with specified cancers and chronic diseases that could have resulted from exposure to nuclear-weapons tests at various U.S. test sites. Eligible claimants include civilian onsite participants, downwinders who lived in areas currently designated by RECA, and uranium workers and ore transporters who meet specified residence or exposure criteria. The Health Resources and Services Administration (HRSA), which oversees the screening, education, and referral services program for RECA populations, asked the National Academies to review its program and assess whether new scientific information could be used to improve its program and determine if additional populations or geographic areas should be covered under RECA. The report recommends Congress should establish a new science-based process using a method called "probability of causation/assigned share" (PC/AS) to determine eligibility for compensation. Because fallout may have been higher for people outside RECA-designated areas, the new PC/AS process should apply to all residents of the continental US, Alaska, Hawaii, and overseas US territories who have been diagnosed with specific RECA-compensable diseases and who may have been exposed, even in utero, to radiation from U.S. nuclear-weapons testing fallout. However, because the risks of radiation-induced disease are generally low at the exposure levels of concern in RECA populations, in most cases it is unlikely that exposure to radioactive fallout was a substantial contributing cause of cancer.
This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
In the decades since the atomic bombing of Hiroshima and Nagasaki, economic and political trends have opened avenues for radiation research while breakthroughs in molecular biology have shed light on radiation's effect on the human body. This volume comprehensively reviews what is now known about human exposure to ionizing radiation, with emphasis on unifying the scientific disciplines that inform this topic. Today's most widely recognized experts in the field examine four broad areas: Physics and dosimetry, including the various systems of A-bomb survivor dosimetry, the effect on survivors of subsequent medical radiation, and chromosome aberrations as biomarkers. Cancer statistics and epidemiology, including a historical review of leukemia risk in A-bomb survivors, the incidence of solid cancer and resulting mortality, and the results of studies of workers exposed to low-level radiation. Genetics, including the path from radiation exposure to cellular effects, carcinogenesis, and mutagenesis. Experts discuss the interaction between radiation and other cancer risk factors, review models of radiation-induced cancer, and report on other aspects of molecular biology. Psychological effects of radiation catastrophesâ€"as seen at Hiroshima and Nagasaki, Three Mile Island, and Chernobylâ€"and consequences of the Atomic Bomb Survivors Relief Law.
Follow-up studies of persons exposed to medical radiation have long shown that radiation induces cancer in man. This, coupled with increasing exposure from other sources including occupational and environmental radiations, has resulted in greater recognition of the importance of research on radiation-induced carcinogenesis and risk assessment with a view to radiation protection. One of the well-known late effects of radiation is the increased incidence of leukemia that occurred among atomic bomb survivors beginning two or three years after expo sure. A remarkable increase of solid tumors including cancers of the thyroid, breast and lung was also observed 10 to 20 years after exposure. Thus, many pathological, clinical and epidemiological studies have been made on radiation carcinogenesis in atomic bomb survivors by investigators at the Atomic Bomb Casualty Commission (ABCC), now known as the Radiation Effects Research Foundation (RERF), as well as by the staff of universities in Hiroshima and Nagasaki. Some of the mechanisms involved in radia tion carcinogenesis in man and associated modifying factors, such as age at time of ex posure and sex, have been elucidated by these studies. The results obtained are being used by such agencies as the International Commission on Radiation Protection (ICRP) for risk estimations of radiation exposure. This monograph presents the results realized thus far in these epidemiological and The incidence of radiation-induced cancer among atomic bomb pathological studies.
Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents. Permanent mutation in genes and chromosomes, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discussed by Advances in Mutagenesis Research are (1) the understanding of the molecular mechanisms leading to mutations, and (2) the prevention of a thoughtless introduction of mutagenic agents into the environment.