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Through its scope and depth of coverage, this book addresses the needs of the vibrant and rapidly growing engineering fields, bioengineering and biomedical engineering, while implementing software that engineers are familiar with. The author integrates introductory statistics for engineers and introductory biostatistics as a single textbook heavily oriented to computation and hands on approaches. For example, topics ranging from the aspects of disease and device testing, Sensitivity, Specificity and ROC curves, Epidemiological Risk Theory, Survival Analysis, or Logistic and Poisson Regressions are covered. In addition to the synergy of engineering and biostatistical approaches, the novelty of this book is in the substantial coverage of Bayesian approaches to statistical inference. Many examples in this text are solved using both the traditional and Bayesian methods, and the results are compared and commented.
Statistics for Biomedical Engineers and Scientists: How to Analyze and Visualize Data provides an intuitive understanding of the concepts of basic statistics, with a focus on solving biomedical problems. Readers will learn how to understand the fundamental concepts of descriptive and inferential statistics, analyze data and choose an appropriate hypothesis test to answer a given question, compute numerical statistical measures and perform hypothesis tests 'by hand', and visualize data and perform statistical analysis using MATLAB. Practical activities and exercises are provided, making this an ideal resource for students in biomedical engineering and the biomedical sciences who are in a course on basic statistics.
A thorough and definitive book that fully addresses traditional and modern-day topics of nonparametric statistics This book presents a practical approach to nonparametric statistical analysis and provides comprehensive coverage of both established and newly developed methods. With the use of MATLAB, the authors present information on theorems and rank tests in an applied fashion, with an emphasis on modern methods in regression and curve fitting, bootstrap confidence intervals, splines, wavelets, empirical likelihood, and goodness-of-fit testing. Nonparametric Statistics with Applications to Science and Engineering begins with succinct coverage of basic results for order statistics, methods of categorical data analysis, nonparametric regression, and curve fitting methods. The authors then focus on nonparametric procedures that are becoming more relevant to engineering researchers and practitioners. The important fundamental materials needed to effectively learn and apply the discussed methods are also provided throughout the book. Complete with exercise sets, chapter reviews, and a related Web site that features downloadable MATLAB applications, this book is an essential textbook for graduate courses in engineering and the physical sciences and also serves as a valuable reference for researchers who seek a more comprehensive understanding of modern nonparametric statistical methods.
This book provides an essential understanding of statistical concepts necessary for the analysis of genomic and proteomic data using computational techniques. The author presents both basic and advanced topics, focusing on those that are relevant to the computational analysis of large data sets in biology. Chapters begin with a description of a statistical concept and a current example from biomedical research, followed by more detailed presentation, discussion of limitations, and problems. The book starts with an introduction to probability and statistics for genome-wide data, and moves into topics such as clustering, classification, multi-dimensional visualization, experimental design, statistical resampling, and statistical network analysis. Clearly explains the use of bioinformatics tools in life sciences research without requiring an advanced background in math/statistics Enables biomedical and life sciences researchers to successfully evaluate the validity of their results and make inferences Enables statistical and quantitative researchers to rapidly learn novel statistical concepts and techniques appropriate for large biological data analysis Carefully revisits frequently used statistical approaches and highlights their limitations in large biological data analysis Offers programming examples and datasets Includes chapter problem sets, a glossary, a list of statistical notations, and appendices with references to background mathematical and technical material Features supplementary materials, including datasets, links, and a statistical package available online Statistical Bioinformatics is an ideal textbook for students in medicine, life sciences, and bioengineering, aimed at researchers who utilize computational tools for the analysis of genomic, proteomic, and many other emerging high-throughput molecular data. It may also serve as a rapid introduction to the bioinformatics science for statistical and computational students and audiences who have not experienced such analysis tasks before.
Discover the fundamental principles of biomedical measurement design and performance evaluation with this hands-on guide. Whether you develop measurement instruments or use them in novel ways, this practical text will prepare you to be an effective generator and consumer of biomedical data. Designed for both classroom instruction and self-study, it explains how information is encoded into recorded data and can be extracted and displayed in an accessible manner. Describes and integrates experimental design, performance assessment, classification, and system modelling. Combines mathematical concepts with computational models, providing the tools needed to answer advanced biomedical questions. Includes MATLAB® scripts throughout to help readers model all types of biomedical systems, and contains numerous homework problems, with a solutions manual available online. This is an essential text for advanced undergraduate and graduate students in bioengineering, electrical and computer engineering, computer science, medical physics, and anyone preparing for a career in biomedical sciences and engineering.
Data Analytics in Biomedical Engineering and Healthcare explores key applications using data analytics, machine learning, and deep learning in health sciences and biomedical data. The book is useful for those working with big data analytics in biomedical research, medical industries, and medical research scientists. The book covers health analytics, data science, and machine and deep learning applications for biomedical data, covering areas such as predictive health analysis, electronic health records, medical image analysis, computational drug discovery, and genome structure prediction using predictive modeling. Case studies demonstrate big data applications in healthcare using the MapReduce and Hadoop frameworks. - Examines the development and application of data analytics applications in biomedical data - Presents innovative classification and regression models for predicting various diseases - Discusses genome structure prediction using predictive modeling - Shows readers how to develop clinical decision support systems - Shows researchers and specialists how to use hybrid learning for better medical diagnosis, including case studies of healthcare applications using the MapReduce and Hadoop frameworks
Provides a one-stop resource for engineers learning biostatistics using MATLAB® and WinBUGS Through its scope and depth of coverage, this book addresses the needs of the vibrant and rapidly growing bio-oriented engineering fields while implementing software packages that are familiar to engineers. The book is heavily oriented to computation and hands-on approaches so readers understand each step of the programming. Another dimension of this book is in parallel coverage of both Bayesian and frequentist approaches to statistical inference. It avoids taking sides on the classical vs. Bayesian paradigms, and many examples in this book are solved using both methods. The results are then compared and commented upon. Readers have the choice of MATLAB® for classical data analysis and WinBUGS/OpenBUGS for Bayesian data analysis. Every chapter starts with a box highlighting what is covered in that chapter and ends with exercises, a list of software scripts, datasets, and references. Engineering Biostatistics: An Introduction using MATLAB® and WinBUGS also includes: parallel coverage of classical and Bayesian approaches, where appropriate substantial coverage of Bayesian approaches to statistical inference material that has been classroom-tested in an introductory statistics course in bioengineering over several years exercises at the end of each chapter and an accompanying website with full solutions and hints to some exercises, as well as additional materials and examples Engineering Biostatistics: An Introduction using MATLAB® and WinBUGS can serve as a textbook for introductory-to-intermediate applied statistics courses, as well as a useful reference for engineers interested in biostatistical approaches.
The first MATLAB-based numerical methods textbook for bioengineers that uniquely integrates modelling concepts with statistical analysis, while maintaining a focus on enabling the user to report the error or uncertainty in their result. Between traditional numerical method topics of linear modelling concepts, nonlinear root finding, and numerical integration, chapters on hypothesis testing, data regression and probability are interweaved. A unique feature of the book is the inclusion of examples from clinical trials and bioinformatics, which are not found in other numerical methods textbooks for engineers. With a wealth of biomedical engineering examples, case studies on topical biomedical research, and the inclusion of end of chapter problems, this is a perfect core text for a one-semester undergraduate course.
An understanding of statistics and experimental design is essential for life science studies, but many students lack a mathematical background and some even dread taking an introductory statistics course. Using a refreshingly clear and encouraging reader-friendly approach, this book helps students understand how to choose, carry out, interpret and report the results of complex statistical analyses, critically evaluate the design of experiments and proceed to more advanced material. Taking a straightforward conceptual approach, it is specifically designed to foster understanding, demystify difficult concepts and encourage the unsure. Even complex topics are explained clearly, using a pictorial approach with a minimum of formulae and terminology. Examples of tests included throughout are kept simple by using small data sets. In addition, end-of-chapter exercises, new to this edition, allow self-testing. Handy diagnostic tables help students choose the right test for their work and remain a useful refresher tool for postgraduates.
A second edition of the easy-to-use standard text guiding biomedical researchers in the use of advanced statistical methods.