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Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Data on water quality and other environmental issues are being collected at an ever-increasing rate. In the past, however, the techniques used by scientists to interpret this data have not progressed as quickly. This is a book of modern statistical methods for analysis of practical problems in water quality and water resources.The last fifteen years have seen major advances in the fields of exploratory data analysis (EDA) and robust statistical methods. The 'real-life' characteristics of environmental data tend to drive analysis towards the use of these methods. These advances are presented in a practical and relevant format. Alternate methods are compared, highlighting the strengths and weaknesses of each as applied to environmental data. Techniques for trend analysis and dealing with water below the detection limit are topics covered, which are of great interest to consultants in water-quality and hydrology, scientists in state, provincial and federal water resources, and geological survey agencies.The practising water resources scientist will find the worked examples using actual field data from case studies of environmental problems, of real value. Exercises at the end of each chapter enable the mechanics of the methodological process to be fully understood, with data sets included on diskette for easy use. The result is a book that is both up-to-date and immediately relevant to ongoing work in the environmental and water sciences.
This book describes EnvStats, a new comprehensive R package for environmental statistics and the successor to the S-PLUS module EnvironmentalStats for S-PLUS (first released in 1997). EnvStats and R provide an open-source set of powerful functions for performing graphical and statistical analyses of environmental data, bringing major environmental statistical methods found in the literature and regulatory guidance documents into one statistical package, along with an extensive hypertext help system that explains what these methods do, how to use these methods, and where to find them in the environmental statistics literature. EnvStats also includes numerous built-in data sets from regulatory guidance documents and the environmental statistics literature. This book shows how to use EnvStats and R to easily: * graphically display environmental data * plot probability distributions * estimate distribution parameters and construct confidence intervals on the original scale for commonly used distributions such as the lognormal and gamma, as well as do this nonparametrically * estimate and construct confidence intervals for distribution percentiles or do this nonparametrically (e.g., to compare to an environmental protection standard) * perform and plot the results of goodness-of-fit tests * compute optimal Box-Cox data transformations * compute prediction limits and simultaneous prediction limits (e.g., to assess compliance at multiple sites for multiple constituents) * perform nonparametric estimation and test for seasonal trend (even in the presence of correlated observations) * perform power and sample size computations and create companion plots for sampling designs based on confidence intervals, hypothesis tests, prediction intervals, and tolerance intervals * deal with non-detect (censored) data * perform Monte Carlo simulation and probabilistic risk assessment * reproduce specific examples in EPA guidance documents EnvStats combined with other R packages (e.g., for spatial analysis) provides the environmental scientist, statistician, researcher, and technician with tools to “get the job done!”
This publication offers a synthesis of the major factors at play in the global food and agricultural landscape. Statistics are presented in four thematic chapters, covering the economic importance of agricultural activities, inputs, outputs and factors of production, their implications for food security and nutrition and their impacts on the environment. The Yearbook is meant to constitute a primary tool for policy makers, researchers and analysts, as well as the general public interested in the past, present and future path of food and agriculture.
Online Statistics: An Interactive Multimedia Course of Study is a resource for learning and teaching introductory statistics. It contains material presented in textbook format and as video presentations. This resource features interactive demonstrations and simulations, case studies, and an analysis lab.This print edition of the public domain textbook gives the student an opportunity to own a physical copy to help enhance their educational experience. This part I features the book Front Matter, Chapters 1-10, and the full Glossary. Chapters Include:: I. Introduction, II. Graphing Distributions, III. Summarizing Distributions, IV. Describing Bivariate Data, V. Probability, VI. Research Design, VII. Normal Distributions, VIII. Advanced Graphs, IX. Sampling Distributions, and X. Estimation. Online Statistics Education: A Multimedia Course of Study (http: //onlinestatbook.com/). Project Leader: David M. Lane, Rice University.