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This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.
This invaluable book explores the delicate interplay between geometry and statistical mechanics in materials such as microemulsions, wetting and growth interfaces, bulk lyotropic liquid crystals, chalcogenide glasses and sheet polymers, using tools from the fields of polymer physics, differential geometry, field theory and critical phenomena. Several chapters have been updated relative to the classic 1989 edition. Morever, there are now three entirely new chapters -- on effects of anisotropy and heterogeneity, on fixed connectivity membranes and on triangulated surface models of fluctuating membranes.
The School explored the delicate interplay between geometry and statistical mechanics in these materials such as microemulsions, wetting and growth interfaces, bulk lyotropic liquid crystals, chalcogenide glasses and sheet polymers, using tools from the fields of polymer physics, of differential geometry and of critical phenomena.
leagues and, in many cases, students, of Professor Onsager. Professor Onsager, himself, has contributed a paper on Illife in early times" to the volume. Among the topics discussed are some interesting applications of low temperature experimental techniques to cardiology and astrophysics. We would like to express our particular appreciation to Mrs. Helga Billings and Miss Sara Lesser for their excellent typing of these Proceedings and to Mrs. Jacquelyn Zagursky, as well as to Mrs. Billings and Miss Lesser for their invaluable assistance with the details of the conference and the publication of these Proceedings. The Editors CONTENTS Section One BIOLOGY Life in the Early Days Lars Onsager. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 The Fluctuating Enzyme Giorgio Careri. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Diffusion Control in Biochemical Reactions Manfred Eigen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Phase Transitions of Phospholipids Julian Sturtevant. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 Theory and Density Measurements of the Lipid Bilayer Phase Transition John F. Nagle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Stability of Helical Nucleic Acids Neville R. Kallenbach. . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Thermodynamic Perspectives and the Origin of Life Sidney W. Fox. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Section Two STATISTICAL MECHANICS High Frequency Dielectric Response in Dipolar Systems Roberto Lobo, John E. Robinson, Sergio Rodriguez. 143 ix x CONTENTS Exact Derivation of the Onsager Limiting Law Thomas J. Murphy 157 The Effect of Wall Charge on the Capillary Rise of Electrolytes Lars Onsager, Edmund Drauglis 167 Density of States of Topologically Disordered Amorphous Semiconductors Jill C. Bonner, J. F. Nagle 201 Irreversibility Willis E. Lamb, Jr. 213 Surface Specific Heat of Crystals.
Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field. - Incorporates contributions from newcomers and established and experienced researchers - Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives - Serves as an indispensable source of information for new scientists
Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field. Incorporates contributions from newcomers and established and experienced researchers Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives Serves as an indispensable source of information for new scientists
This book aims to cover a broad range of topics in statistical physics, including statistical mechanics (equilibrium and non-equilibrium), soft matter and fluid physics, for applications to biological phenomena at both cellular and macromolecular levels. It is intended to be a graduate level textbook, but can also be addressed to the interested senior level undergraduate. The book is written also for those involved in research on biological systems or soft matter based on physics, particularly on statistical physics. Typical statistical physics courses cover ideal gases (classical and quantum) and interacting units of simple structures. In contrast, even simple biological fluids are solutions of macromolecules, the structures of which are very complex. The goal of this book to fill this wide gap by providing appropriate content as well as by explaining the theoretical method that typifies good modeling, namely, the method of coarse-grained descriptions that extract the most salient features emerging at mesoscopic scales. The major topics covered in this book include thermodynamics, equilibrium statistical mechanics, soft matter physics of polymers and membranes, non-equilibrium statistical physics covering stochastic processes, transport phenomena and hydrodynamics. Generic methods and theories are described with detailed derivations, followed by applications and examples in biology. The book aims to help the readers build, systematically and coherently through basic principles, their own understanding of nonspecific concepts and theoretical methods, which they may be able to apply to a broader class of biological problems.
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. *Discusses the current stat of electrostatics in biomolecular simulations and future directions *Includes information on time and length scales in lipid bilayer simulations *Includes a chapter on the nature of lipid rafts
This book presents a comprehensive and coherent picture of how molecules diffuse across a liquid that is, on average, only two molecules thick. It begins by characterizing bilayers structurally, using X-ray diffraction, and then mechanically by measuring elastic moduli and mechanisms of failure. Emphasis is placed on the stability and mechanical properties of plant membranes that are subject to very large osmotic and thermal stresses. Using this information, the transport of molecules of increasing complexity across bilayers is analyzed.
The lipid bilayer is the most basic structural element of cell membranes. A wide range of topics are covered in this volume, from the origin of the lipid bilayer concept, to current applications and experimental techniques. Each chapter in this volume is self-contained and describes a group's research, providing detailed methodology and key references useful for researchers. Lipid bilayer research is of great interest to many because of it's interdisciplinary nature.·Provides an overview of decades of research on the lipid bilayer·38 contributed chapters, by leading scientists, cover a wide range of topics in one authoritative volume·Book coincides with 40th anniversary of BLM