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The Wiley Classics Library consists of selected books that have become recognized classics in their respective fields. With these new unabridged and inexpensive editions, Wiley hopes to extend the life of these important works by making them available to future generations of mathematicians and scientists. This title addresses those basic aspects of research design which are common to many related fields in the social sciences, health sciences, education, and market research. The work presents a unified approach to a common core of problems of statistical design that exists in all these fields, along with basic similarities in practical solutions. Describing many examples and analogies that are 'portable' from application field to application field, Statistical Design for Research deals with designs that are the primary basis of research studies, but are neglected in most statistical textbooks that tend to concentrate on statistical analysis. This text takes a broader, more general and philosophical view of the statistics for the more fundamental aspects of design than do the standard treatments of experimental design. Extensively illustrated and carefully organized into seven chapters and 44 sections, this book can be readily consulted by research workers or graduate students!
"Free CD contains several real and artificial data sets used in the book in SPSS, SYSTAT, and ASCII formats"--Cover
Statistical design is one of the fundamentals of our subject, being at the core of the growth of statistics during the previous century. In this book the basic theoretical underpinnings are covered. It describes the principles that drive good designs and good statistics. Design played a key role in agricultural statistics and set down principles of good practice, principles that still apply today. Statistical design is all about understanding where the variance comes from, and making sure that is where the replication is. Indeed, it is probably correct to say that these principles are even more important today.
This book takes the reader through the entire research process: choosing a question, designing a study, collecting the data, using univariate, bivariate and multivariable analysis, and publishing the results. It does so by using plain language rather than complex derivations and mathematical formulae. It focuses on the nuts and bolts of performing research by asking and answering the most basic questions about doing research studies. Making good use of numerous tables, graphs and tips, this book helps to demystify the process. A generous number of up-to-date examples from the clinical literature give an illustrated and practical account of how to use multivariable analysis.
This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.
Research Design and Statistical Analysis provides comprehensive coverage of the design principles and statistical concepts necessary to make sense of real data. The book’s goal is to provide a strong conceptual foundation to enable readers to generalize concepts to new research situations. Emphasis is placed on the underlying logic and assumptions of the analysis and what it tells the researcher, the limitations of the analysis, and the consequences of violating assumptions. Sampling, design efficiency, and statistical models are emphasized throughout. As per APA recommendations, emphasis is also placed on data exploration, effect size measures, confidence intervals, and using power analyses to determine sample size. "Real-world" data sets are used to illustrate data exploration, analysis, and interpretation. The book offers a rare blend of the underlying statistical assumptions, the consequences of their violations, and practical advice on dealing with them. Changes in the New Edition: Each section of the book concludes with a chapter that provides an integrated example of how to apply the concepts and procedures covered in the chapters of the section. In addition, the advantages and disadvantages of alternative designs are discussed. A new chapter (1) reviews the major steps in planning and executing a study, and the implications of those decisions for subsequent analyses and interpretations. A new chapter (13) compares experimental designs to reinforce the connection between design and analysis and to help readers achieve the most efficient research study. A new chapter (27) on common errors in data analysis and interpretation. Increased emphasis on power analyses to determine sample size using the G*Power 3 program. Many new data sets and problems. More examples of the use of SPSS (PASW) Version 17, although the analyses exemplified are readily carried out by any of the major statistical software packages. A companion website with the data used in the text and the exercises in SPSS and Excel formats; SPSS syntax files for performing analyses; extra material on logistic and multiple regression; technical notes that develop some of the formulas; and a solutions manual and the text figures and tables for instructors only. Part 1 reviews research planning, data exploration, and basic concepts in statistics including sampling, hypothesis testing, measures of effect size, estimators, and confidence intervals. Part 2 presents between-subject designs. The statistical models underlying the analysis of variance for these designs are emphasized, along with the role of expected mean squares in estimating effects of variables, the interpretation of nteractions, and procedures for testing contrasts and controlling error rates. Part 3 focuses on repeated-measures designs and considers the advantages and disadvantages of different mixed designs. Part 4 presents detailed coverage of correlation and bivariate and multiple regression with emphasis on interpretation and common errors, and discusses the usefulness and limitations of these procedures as tools for prediction and for developing theory. This is one of the few books with coverage sufficient for a 2-semester course sequence in experimental design and statistics as taught in psychology, education, and other behavioral, social, and health sciences. Incorporating the analyses of both experimental and observational data provides continuity of concepts and notation. Prerequisites include courses on basic research methods and statistics. The book is also an excellent resource for practicing researchers.
Quantitative and Statistical Research Methods This user-friendly textbook teaches students to understand and apply procedural steps in completing quantitative studies. It explains statistics while progressing through the steps of the hypothesis-testing process from hypothesis to results. The research problems used in the book reflect statistical applications related to interesting and important topics. In addition, the book provides a Research Analysis and Interpretation Guide to help students analyze research articles. Designed as a hands-on resource, each chapter covers a single research problem and offers directions for implementing the research method from start to finish. Readers will learn how to: Pinpoint research questions and hypotheses Identify, classify, and operationally define the study variables Choose appropriate research designs Conduct power analysis Select an appropriate statistic for the problem Use a data set Conduct data screening and analyses using SPSS Interpret the statistics Write the results related to the problem Quantitative and Statistical Research Methods allows students to immediately, independently, and successfully apply quantitative methods to their own research projects.
Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters. Developed from the authors’ courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase 2/3 seamless design and trials with predictive biomarkers, exploit multiple testing procedures, and explain the concept of estimand, intercurrent events, and different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students and practitioners a multidisciplinary understanding of the concepts and techniques involved in designing, monitoring, and analyzing various types of trials. The book’s balanced set of homework assignments and in-class exercises are appropriate for students and researchers in (bio)statistics, epidemiology, medicine, pharmacy, and public health.
Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
"In this Second Edition of Design of Experiments: Statistical Principles of Research Design and Analysis, Bob Kuehl continues to treat research design as a very practical subject. He emphasizes the importance of developing a treatment design based on research hypothesis as an initial step and then developing an experimental or observational study design that facilitates efficient data collection. With the book's wide array of examples from actual studies from many scientific and technological fields, Kuehl constantly reinforces the research design process."--Back cover.