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Specialised Pharmaceutical Formulation is an essential, up to date resource and will equip readers with the ability to effectively and reliably produce products intended for less common and novel routes of administration which can be approved, manufactured and made available to administer to patients.
Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product. Modern formulation science deals with biologics as well as small molecules. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry. The book provides an understanding of the links between formulation theory and the practicalities of processing in a commercial environment, giving researchers the knowledge to produce effective pharmaceutical products that can be approved and manufactured. The first chapters introduce readers to different dosage forms, including oral liquid products, topical products and solid dosage forms such as tablets and capsules. Subsequent chapters cover pharmaceutical coatings, controlled release drug delivery and dosage forms designed specifically for paediatric and geriatric patients. The final chapter provides an introduction to the vital role intellectual property plays in drug development. Covering modern processing methods and recent changes in the regulatory and quality demands of the industry, Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry.
The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes. Key Features: Presents a practical guide for both industry and academia Focuses on and draws together the fundamental principles behind transdermal and topical drug delivery Illustrates the practicalities of formulation design using key case studies Gives an understanding of the skin as a route of delivery and how formulation development for such application differs from that for other administration routes
No other area of regulatory compliance receives more attention and scrutiny by regulatory authorities than the regulation of sterile products, for obvious reasons. With the increasing number of potent products, particularly the new line of small protein products, joining the long list of proven sterile products, the technology of manufacturing ster
Supplementary videos demonstrating various dispensing procedures can be viewed online at www.pharmpress.com/PCDvideos. --Book Jacket.
The book presents the fundamentals of nanomaterials, discusses the direct applications of nanomaterials to the biomedical sector, and explores the potential therapeutic applications of nanotheranostics. This book focuses on the fundamental features of various nanomaterials that are related to the development of biomedical technologies. These fundamental qualities are broken up into three parts: prevention, diagnostics, and therapeutics. When it comes to infectious diseases, prevention is of the utmost importance. Highly advanced nanomaterials including silver, titanium, graphene-based filters, and copper nanoparticles are used to fight infectious illnesses. Once the symptoms have been recognized in the patients, through the use of effective and straightforward nanodiagnostic techniques, the diseases can be accurately localized in either a qualitative or quantitative manner. Nanodiagnostics tools currently dominate the field of biomedical diagnostics because of their high degree of accuracy, low requirement for samples and reagents, user-friendliness, portability, and capacity to perform point-of-care (POC) applications. Nanomaterials are widely used in imaging due to many factors, including: their signal generation and amplification abilities; the ongoing development of reliant new imaging techniques, such as photoacoustic imaging and Raman imaging; their targeting potential, due to the possibility of functionalizing their surface with cancer-targeting moieties; their multimodality, since some nanomaterials can generate signals for more than one imaging technique; and their affordability. Modern therapeutics explores the various nanotechnological advances to cure the site-specific cancer treatment most prominently. The book explores the fundamentals of nanomaterials and discloses their direct application to the biomedical field. Finally, the book discusses future therapeutic applications of nanotheranostics. Audience The book will be read by scientists, researchers, and post-graduate students in the biomedical-related engineering field, nanoscience and nanotechnology, materials science, and bionanotechnology.
This is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs but in this context also the social impact which drugs have in modern societies is highlighted. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book * Covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases * Gives guidance on how doctors should act so that drugs can be used effectively and safely * Encourages the rational use of drugs in society This book brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.
This textbook provides a structured, informed approach to the understanding and appreciation of drug action and effect providing a detailed description and discussion of pharmacokinetics and pharmacodynamics for nurses.The text focuses and emphasizes safe prescribing and administration of medication highlighting the possible harm to patient in terms of adverse reactions. This book also includes the seldom addressed facet of pharmacotherapeutics; drug formulation as applied to practice, and adverse reactions. It informs on the medication used to manage diabetes mellitus, respiratory disease, gastrointestinal tract, the central nervous system and many other affections. Uniting these essential pharmacological processes and applying them to physiological system based medications, this work highlights issues relevant to drug interaction and important nursing responsibilities associated with administration/prescribing. The overall aim of the text is to equip the nurse with an understanding of issues related to pharmacotherapeutics that is aligned to current nursing roles and statutory requirements.
This book serves as a formulation and processing guide during the development of pelletized dosage forms. It provides the pharmaceutical technologist with basic information about the design aspects of the relevant processing equipment.