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This open access book focuses on Switzerland-based medium-sized companies with a longstanding export tradition and a proven dominance in global niche markets. Based upon in-depth documentation and analysis of 36 Swiss companies over their entire history, an expert team of authors presents several parallels in the pathways and success factors which allowed these firms to become dominant and operate from a high-cost location such as Switzerland. The book enhances these insights by providing detailed company profiles documenting the company history, development, and how their relevant global niche positions were reached. Readers will benefit from these profiles as they compile a diverse selection of industries, mainly active within the B2B sector, with mostly mature companies (60 years to older than 100 years since founding) and different types of ownership structures including family firms. ‘Masterpieces of Swiss Entrepreneurship’ brings unique learning opportunities to owners and leaders of SMEs in Switzerland and elsewhere. Findings are based on detailed bottom-up research of 36 companies -- without any preconceived notions. The book is both conceptual and practical. It fosters understanding for different choices in development pathways and management practices. Matti Alahuhta, Chairman DevCo Partners, ex-CEO Kone, Board member of several global listed companies, Helsinki, Finland Start-up entrepreneurs need proven models from industry which demonstrate the various paths to success. “Masterpieces of Swiss Entrepreneurship” provides deep insights highlighting these models and the important trade-offs entrepreneurial teams must consider when choosing the path of high growth or of maximum control, as they are often mutually exclusive. Gina Domanig, Managing Partner, Emerald Technology Ventures, Zurich
This is a fascinating account of two great scientists of the 20th century: Einstein and Heisenberg, discoverers, respectively, of the theory of relativity and quantum mechanics. It connects the history of modern physics to the life stories of these two extraordinary physicists.These discoveries laid the foundation of modern physics, without which our digitized world of computers, satellites, and innovative materials would not be possible. This book also describes in comprehensible terms the complicated science underlying the two discoveries.The twin biography highlights the parallels and differences of these two luminaries, showing how their work shaped the 20th century into the century of physics.
Micro-assembly is a key enabling technology for cost effective manufacture of new generations of complex micro products. It is also a critical technology for retaining mdustrial capabilities in high labour cost areas such as Europe since up to 80% of the production cost in some industries is attributed directly to assembly processes. With the continuous trend for product miniaturisation, the scientific and technologi cal developments in micro-assembly are expected to have a significant long-term economic, demographic and social impact. A distinctive feature of the process is that surface forces are often dominant over gravity forces, which determines a number of specific technical challenges. Critical areas which are currently being addressed include development of assembly systems with high positional accuracy, micro gripping methods that take into ac count the adhesive surface forces, high precision micro-feeding techniques and mi cro-joining processes. Micro-assembly has developed rapidly over the last few years and all the pre dictions are that it will remain a critical technology for high value products in a number of key sectors such as healthcare, communications, defence and aerospace. The key challenge is to match the significant technological developments with a new generation of micro products that will establish firmly micro-assembly as a core manufacturing process.
This overview of the development of continuum mechanics throughout the twentieth century is unique and ambitious. Utilizing a historical perspective, it combines an exposition on the technical progress made in the field and a marked interest in the role played by remarkable individuals and scientific schools and institutions on a rapidly evolving social background. It underlines the newly raised technical questions and their answers, and the ongoing reflections on the bases of continuum mechanics associated, or in competition, with other branches of the physical sciences, including thermodynamics. The emphasis is placed on the development of a more realistic modeling of deformable solids and the exploitation of new mathematical tools. The book presents a balanced appraisal of advances made in various parts of the world. The author contributes his technical expertise, personal recollections, and international experience to this general overview, which is very informative albeit concise.
This book is an overview of replication technology for micro- and nanostructures, focusing on the techniques and technology of hot embossing, a scaleable and multi-purpose technology for the manufacture of devices such as BioMEMS and microfluidic devices which are expected to revolutionize a wide range of medical and industrial processes over the coming decade.The hot embossing process for replicating microstructures was developed by the Forschungszentrum Karlsruhe (Karlsruhe Institute of Technology) where the author is head of the Nanoreplication Group. Worgull fills a gap in existing information by fully detailing the technology and techniques of hot embossing. He also covers nanoimprinting, a process related to hot embossing, with examples of actual research topics and new applications in nanoreplication. - A practical and theoretical guide to selecting the materials, machinery and processes involved in microreplication using hot embossing techniques - Compares different replication processes such as: micro injection molding, micro thermoforming, micro hot embossing, and nanoimprinting - Details commercially available hot embossing machinery and components like tools and mold inserts
This book addresses the possibilities and challenges in mimicking biological membranes and creating membrane-based sensor and separation devices. Recent advances in developing biomimetic membranes for technological applications will be presented with focus on the use of integral membrane protein mediated transport for sensing and separation. It describes the fundamentals of biosensing as well as separation and shows how the two processes are working in a cooperative manner in biological systems. Biomimetics is a truly cross-disciplinary approach and this is exemplified using the process of forward osmosis will be presented as an illustration of how advances in membrane technology may be directly stimulated by an increased understanding of biological membrane transport. In the development of a biomimetic sensor/separation technology, both channels (ion and water channels) and carriers (transporters) are important. An ideal sensor/separation device requires the supporting biomimetic matrix to be virtually impermeable to anything but the solute in question. In practice, however, a biomimetic support matrix will generally have finite permeabilities to water, electrolytes, and non-electrolytes. These non-protein mediated membrane transport contributions will be presented and the implications for biomimetic device construction will be discussed. New developments in our understanding of the reciprocal coupling between the material properties of the biomimetic matrix and the embedded proteins will be presented and strategies for inducing biomimetic matrix stability will be discussed. Once reconstituted in its final host biomimetic matrix the protein stability also needs to be maintained and controlled. Beta-barrel proteins exemplified by the E. Coli outer membrane channels or small peptides are inherently more stable than alpha-helical bundle proteins which may require additional stabilizing modifications. The challenges associated with insertion and stabilization of alpha-helical bundle proteins including many carriers and ligand and voltage gated ion (and water) channels will be discussed and exemplified using the aquaporin protein. Many biomimetic membrane applications require that the final device can be used in the macroscopic realm. Thus a biomimetic separation device must have the ability to process hundred of liters of permeate in hours – effectively demanding square-meter size membranes. Scalability is a general issue for all nano-inspired technology developments and will be addressed here in the context biomimetic membrane array fabrication. Finally a robust working biomimetic device based on membrane transport must be encapsulated and protected yet allowing massive transport though the encapsulation material. This challenge will be discussed using microfluidic design strategies as examples of how to use microfluidic systems to create and encapsulate biomimetic membranes. The book provides an overview of what is known in the field, where additional research is needed, and where the field is heading.
Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.
Although somatosensory system works in tandem with the motor system in biology, the majority of the prosthetics research and commercial efforts had focused on accommodating movement deficits. With the development of neuroprostheses in the last 15 years, it has become evident that somatosensory input (mainly as touch and proprioception) is essential for motor control, manipulating objects, and embodiment, in addition to its primary role for sensory perception. Somatosensory Feedback for Neuroprosthetics covers all relevant aspects to facilitate learning and doing research and development in the field. To understand the properties of the body to create viable solutions, this book starts with chapters reviewing the basic anatomy, physiology, and psychophysics of the somatosensory system, sensorimotor control, and instrumentation. Some sections are dedicated to invasive (peripheral and central, mainly cortical) and noninvasive (vibrotactile, electrotactile, etc.) approaches. Final chapters cover future technologies such as novel sensors and electrodes, safety, and clinical testing, and help to make up future prospects for this field with an emphasis on development and end use. With contributions from renowned experts, the contents include their recent findings and technical details necessary to understand those findings. Provides a concise review of the somatosensory system and latest advances in the use of somatosensory feedback for neuroprosthetics Analyzes many approaches to somatosensory feedback Provides the most detailed work on somatosensory neuroprostheses, their development, and applications in real life work