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In the past 20 years micronutrients have assumed great public health importance and a considerable amount of research has lead to increasing knowledge of their physiological role. Because it is a rapidly developing field, the WHO and FAO convened an Expert Consultation to evaluate the current state of knowledge. It had three main tasks: to review the full scope of vitamin and minerals requirements; to draft and adopt a report which would provide recommended nutrient intakes for vitamins A, C, D, E, and K; the B vitamins; calcium; iron; magnesium; zinc; selenium; and iodine; to identify key issues for future research and make preliminary recommendations for the handbook. This report contains the outcome of the Consultation, combined with up-to-date evidence that has since become available.
In this volume, experts from universities, government labs and industry share their findings on the microbiological, biochemical and molecular aspects of biodegradation and bioremediation. The text covers numerous topics, including: bioavailability, biodegradation of various pollutants, microbial community dynamics, properties and engineering of important biocatalysts, and methods for monitoring bioremediation processes. Microbial processes are environmentally compatible and can be integrated with non-biological processes to detoxify, degrade and immobilize environmental contaminants.
Starting in the early 1970s, a type of programmed cell death called apoptosis began to receive attention. Over the next three decades, research in this area continued at an accelerated rate. In the early 1990s, a second type of programmed cell death, autophagy, came into focus. Autophagy has been studied in mammalian cells for many years. The recen
The aim of this review was to provide an evidence base for policy development on vocational rehabilitation - defined as whatever helps someone with a health problem to stay at, return to and remain at work. The focus was on adults of working age, the common health problems that account for two-thirds of long-term sickness (mild/moderate musculoskeletal, mental health and cardio-respiratory conditions) and work outcomes (staying at, returning to and remaining in work). Data from some 450 scientific reviews and reports were included in evidence tables. The review demonstrates that there is a strong scientific evidence base for many aspects of vocational rehabilitation, a good business case for it and more evidence on cost-benefits than for many health and social policy areas. Generic and condition-specific findings are reported, and practical suggestions offered for the differing types of people affected by health problems. Vocational rehabilitation should be a fundamental element of government strategy to improve the health of working age people.
This book has three main goals. The first is to celebrate the work of a great public health figure, the late A.J. (Tony) McMichael (1942–2014). The second is to position contemporary public health issues in an interdisciplinary context and in ways that highlight the interdependency between the environment, human institutions and behaviours; a broad approach championed by Tony. The third is to encourage emerging and future public health leaders to advocate for policies and cultural change to sustain and improve human health, from a foundation of objective scholarship. The book’s foreword and 38 chapters were written by people who were inspired by Tony; many of whom worked with him at some point in the last 40 years. Its structure reflects five major public health domains, each of which Tony made major contributions to in an extremely productive academic life: occupational health and safety; environmental and social epidemiology; nutrition and food systems; climate change and health; and ecosystem change and infectious disease. The final section, ‘Transformation’, is dedicated to Tony’s desire for public health scientists to propose adaptive and mitigating solutions to the problems they were observing. Each section contains at least one key publication involving Tony. There is also a selection of artworks from an exhibition which formed part of the conference held to honour Tony at The Australian National University in 2012. This conference formed the first part of Tony’s festschrift, completed by this book.
Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Bovine tuberculosis (bTB) is a significant zoonotic pathogen with a global distribution, and a considerable economic impact. It has a notoriously complex epidemiology, varying by affected region and often involving multiple-host species. Here we present an international collection of papers that address both national and international factors impacting on the control of bovine tuberculosis. We hope this Research Topic will provide a forum which may generate a greater understanding of the disease in a wider context, and inform future eradication efforts through the design of more effective interventions.