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Amines and Schizophrenia is a collection of articles that survey and discuss the biochemical basis present, if any, in schizophrenia, focusing on the role of certain amines. The book discusses certain hypotheses dealing with the field of bio-chemistry as the basis for diseases such as schizophrenia, manic-depressive psychosis, and related diseases. Discussions start with the properties of mescaline, because the psychotic effect of the drug has some aspects similar to that of a schizophrenic syndrome. One paper examines the presence of certain amines, such as norepinephrine, dopamine, and serotonin in the brain, including their role in the synaptic transmission of nerve impulses in the central nervous system. Other papers review the role of derangements of tryptophan metabolism in psychotic behavior; the metabolic interrelationships of tryptophan and methionine in mental illness; and the results obtained with psychomimetic and non-psychomimetic congeners of three classes of indoleamines including LSD. The book gives more details on the actions of various biological amines on single neurons in the limbic system of the brain. The text also evaluates the use of hallucinogenic drugs in considering their heuristic value in the study of the biochemical basis of mental function. The selection will prove relevant for psychologists, psychiatrists, drug researchers, pharmacologists, and chemical laboratory workers and technicians.
This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States. Kay draws out the historical specificity in the process by which the central biological problem of DNA-based protein synthesis came to be metaphorically represented as an information code and a writing technology—and consequently as a “book of life.” This molecular writing and reading is part of the cultural production of the Nuclear Age, its power amplified by the centuries-old theistic resonance of the “book of life” metaphor. Yet, as the author points out, these are just metaphors: analogies, not ontologies. Necessary and productive as they have been, they have their epistemological limitations. Deploying analyses of language, cryptology, and information theory, the author persuasively argues that, technically speaking, the genetic code is not a code, DNA is not a language, and the genome is not an information system (objections voiced by experts as early as the 1950s). Thus her historical reconstruction and analyses also serve as a critique of the new genomic biopower. Genomic textuality has become a fact of life, a metaphor literalized, she claims, as human genome projects promise new levels of control over life through the meta-level of information: control of the word (the DNA sequences) and its editing and rewriting. But the author shows how the humbling limits of these scriptural metaphors also pose a challenge to the textual and material mastery of the genomic “book of life.”
Confronting the Experts brings together six personal case histories of challenges to establishment experts. The authors tell why they questioned conventional wisdom, what methods they used, how they dealt with the experts' response, and what lessons they learned. Because the book shows how powerful groups can get their way by gaining the support of intellectual authorities and also how these authorities can be challenged, it provides insights into the issues of power, dissent, and social change. Included are Sharon Beder's research on sewage and how it helped to undermine the credibility of the Sydney Water Board; Mark Diesendorf's scientific and social critique of fluoridation; Edward Herman's exposition of the flaws in the establishment perspective on terrorism; Harold Hillman's questioning of the validity of standard methods used in biology, such as subcellular fractionation and electron microscopy; Michael Mallory and Gordon Moran's challenge to the orthodox interpretation of a famous painting in Siena, Italy; and Dhirendra Sharma's confrontation with India's nuclear establishment.