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Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. 'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.' Mark Ridley, Department of Zoology, University of Oxford
This is the critically-acclaimed true account of the promising young Harvard student's suicide and the bizarre and controversial therapy of his psychiatrist as written by Boston Globe reporter Eileen McNamara. This is a story that has made national headlines.
A chilling indictment on the state of the American family, and the recent drive to deny the fundamental differences between the sexes, Men and Marriage is "an outstandingly important and well-argued book, strangely moving in its combination of scholarly dilligence, common sense, courage, and devotion to the res publica of human civilization".--National Review.
First published in 1993, The Virgin Suicides announced the arrival of a major new American novelist. In a quiet suburb of Detroit, the five Lisbon sisters—beautiful, eccentric, and obsessively watched by the neighborhood boys—commit suicide one by one over the course of a single year. As the boys observe them from afar, transfixed, they piece together the mystery of the family’s fatal melancholy, in this hypnotic and unforgettable novel of adolescent love, disquiet, and death. Jeffrey Eugenides evokes the emotions of youth with haunting sensitivity and dark humor and creates a coming-of-age story unlike any of our time. Adapted into a critically acclaimed film by Sofia Coppola, The Virgin Suicides is a modern classic, a lyrical and timeless tale of sex and suicide that transforms and mythologizes suburban middle-American life.
Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. 'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.' Mark Ridley, Department of Zoology, University of Oxford
What other treatment focuses on surgery while 30% of the patients commit suicide?Dr. Charles Ihlenfeld, a colleague of Dr. Harry Benjamin, reported in 1979 that 80% of those seeking a sex change should not have one and frequently too many of them committed suicide. Not much has changed since then.Consider the evidence: most who have had sex change surgery consider suicide, 41% make an attempt and about a third are in so much pain that, unable to see any other option, take their life.This book explores the issues behind transgender suicide.
Jesse is a twenty-nine year old adrift in San Francisco's demimonde of sexually ambiguous, drug-taking outsiders, desperately trying to sustain a connection with her bisexual boyfriend. She becomes caretaker and confidante to Madame Pig, a grotesque, besotted recluse. Jesse also meets Madison, Pig's daughter or lover or both, who uses others' desires for her own purposes, and who leads Jesse into a world beyond all boundaries. As startling, original and vital as it was when first published, Suicide Blonde is an intensely erotic story of one young woman's sexual and psychological odyssey and a modern cult classic.
Dorais and Lajeunesse analyse the adverse ways being stigmatized as homosexual affects personality and behaviour, discerning four types of reaction: the 'perfect boy,' whose perfectionism and asexuality are an attempt to minimize the difference between how he is perceived and what he is supposed to be; the 'chameleon,' who attempts to keep everyone from suspecting his secret but constantly feels like an impostor; the 'token fag,' who serves as a scapegoat to his peers, especially at school, and suffers a consequent rejection and lack of self-esteem; and the 'rebel,' who actively rejects any stigma based on his sexual orientation and non-conformity. They show that those who are heterosexual but suspected of being homosexual are most at risk of suicide and make recommendations for suicide prevention.
The New York Times bestselling “taut, sophisticated thriller” (BCCB, starred review) packed with twists and turns that will leave you breathless. They say Delia burned herself to death in her stepfather’s shed. They say it was suicide. But June doesn’t believe it. June and Delia used to be closer than anything. Best friends in that way that comes before everyone else—before guys, before family. It was like being in love, but more. They had a billion secrets, binding them together like thin silk cords. But one night a year ago, everything changed. June, Delia, and June’s boyfriend Ryan were just having a little fun. Their good time got out of hand. And in the cold blue light of morning, June knew only this—things would never be the same again. And now, a year later, Delia is dead. June is certain she was murdered. And she owes it to her to find out the truth…which is far more complicated than she ever could have imagined. Sexy, dark, and atmospheric, Suicide Notes from Beautiful Girls will keep you guessing until the very last page.