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This Best Practices Guidance addresses compliance and enforcement issues as they relate to pesticides and associated health and environmental risks. The objective of this document is to provide guidance for promoting and monitoring compliance and for assessing and mitigating risks of non-compliance.
This document provides additional detailed guidance on testing of chemicals according to OECD Test Guideline No. 505: Testing of Chemicals on Residues in Livestock. Specifically, it describes current differences in OECD countries in livestock feeding practices and diet composition and factors influencing the determination of dietary burden and dose selection, and provides guidance for interpreting results (including example calculations for dietary burdens and MRL setting) from OECD Test Guideline No. 505 studies.
The Global Harmonised Submission Transport Standard (GHSTS) is a standardised set of technical specifications for assembling electronic files for pesticide registration in a predefined manner. Once assembled according to the GHSTS, the dossier files can be transferred from a business to a regulatory authority and can be used in a regulatory process.
A clear, efficient, and modern regulatory framework for pesticides is essential for addressing their impacts on human health and the environment, supporting a life-cycle approach to their management, and ensuring crop protection and a sustainable agricultural industry. This report identifies the gaps, barriers, implementation flaws and inefficiencies that affect the regulatory framework of pesticides in Mexico.
On 20 February 2019, OECD Council adopted the Recommendation on Countering the Illegal Trade of Pesticides to strengthen cooperation between countries and inspectors. A Best Practice Guidance was developed to provide guidance for inspectors and regulatory authorities on best practices for identifying and tackling illegal pesticides throughout the complete lifecycle of a pesticide, from manufacture, through formulation, trade and use to destruction.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety. - Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field - New chapters consider fundamental attributes for additional product classes including protein therapeutics, nucleic acid pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, vaccines, agricultural and bulk chemicals, and assigning adversity - Chapters dealing with product-specific practices address pathology and regulatory issues - Chapters offer high-quality and up-to-date content in a trusted work written by the collaborative efforts of many leading international subject matter experts - Hundreds of full-color images and diagrams are featured in both the print and electronic versions of this book to illustrate classic examples and highlight difficult concepts
The guidance provided in this publication is on enforcing compliance by on-site inspection of companies involved in pesticide production, import, distribution and retail sale. The publication is intended to be a practical, hands-on tool, with checklists that inspectors can use to prepare and conduct inspections at various sites and impose fines or penalties if deficiencies are found. It proposes a format for the report that inspectors submit to the responsible authorities after an inspection and that is filed for future reference.
The guidance provided in this publication is on enforcing compliance by on-site inspection of companies involved in pesticide production, import, distribution and retail sale. The publication is intended to be a practical, hands-on tool, with checklists that inspectors can use to prepare and conduct inspections at various sites and impose fines or penalties if deficiencies are found. It proposes a format for the report that inspectors submit to the responsible authorities after an inspection and that is filed for future reference. The guidance was prepared with the support of the FAO/WHO Joint Meeting on Pesticide Management, which advises FAO and WHO on producing guidance to promote compliance with the International Code of Conduct on Pesticide Management. The document was reviewed by experts of the Working Groups on Biocides and Pesticides of the Organisation for Economic Co‐operation and Development, and their contributions are gratefully acknowledged.
This report includes the outcomes of the workshop discussions, as well as the overall workshop conclusions (Section 4) and recommendations (Section 5) targeted at governments, all stakeholders and OECD.
The understanding that some pesticides are more hazardous than others is well established. Recognition of this is reflected by the World Health Organization (WHO) Recommended Classification of Pesticides by Hazard, which was first published in 1975. The document classifies pesticides in one of five hazard classes according to their acute toxicity. In 2002, the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) was introduced, which in addition to acute toxicity also provides classification of chemicals according to their chronic health hazards and environmental hazards.