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- The topics covered in the six sections of the book are Epidemiology and Environment, Precursors, Pathophysiological Mechanisms, Genetics, Controversies in Schizophrenia, and Treatment. - Reflects the progress made on Schizophrenia since 1986.
The present volume contains the lectures of the symposium on 'Risk and Protective Factors in Schizophrenia - towards a conceptual Model of the Disease Process', which was held at the International Science Forum of the University of Heidelberg on October, 2001. The topics of the program were 'Genetic risk factors and gene environment interaction', 'Psychotic and negative symptoms in the general population as risk-factors', 'Etiological risk factors in embryonal life, childhood and adolescence', 'Prepsychotic prodromi and stage models of the development of psychosis', 'Brain development, structural and functional morphology of the early course', 'Urban versus rural life, migration and social chains as causal risk factors?', 'Psychological and neurobiological (estrogen, erythropoietine) protective factors'. The book covers a wide scope of recent research and knowledge about schizophrenia. TOC:Introduction.- Genetic and Population-related Risk Factors.- Developmental Disorders of the Brain.- Environmental Risk Factors.- Indicators of Schizophrenia in Childhood and Adolescence.- Psychopathological Predictors of the Course of Schizophrenia.- Perspectives of Neuroprotective Interventions.- Psychoprotective factors.- Developments and Perspectives.
#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease. "Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah Winfrey Don and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family? What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations. With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.
An international team of leading researchers and clinicians provides the first comprehensive, epidemiological overview of this multi-faceted and still-perplexing disorder. Controversial issues such as the validity of discrete or dimensional classifications of schizophrenia and the continuum between psychosis and 'normality' are explored in depth. Separate chapters are devoted to topics of particular relevance to schizophrenia such as suicide, violence and substance abuse. Finally, new prospects for treatment and prevention are considered.
This is a major international textbook for psychiatrists and other professionals working in the field of mental healthcare. With contributions from opinion-leaders from around the globe, this book will appeal to those in training as well as to those further along the career path seeking a comprehensive and up-to-date overview of effective clinical practice backed by research evidence. The book is divided into cohesive sections moving from coverage of the tools and skills of the trade, through descriptions of the major psychiatric disorders and on to consider special topics and issues surrounding service organization. The final important section provides a comprehensive review of treatments covering all of the major modalities. Previously established as the Essentials of Postgraduate Psychiatry, this new and completely revised edition is the only book to provide this depth and breadth of coverage in an accessible, yet authoritative manner.
Interrogating the relationship between women and psychosis from a variety of perspectives, this edited collection explores personal, literary, spiritual, psychological, biological, and psychodynamic approaches. The contributors reflect on medieval mystics and witches, postpartum psychosis, disordered eating, art and literature, feminism, and male/female differences in schizophrenia. Women with experience of psychosis, psychotherapists, and a shaman provide first-person accounts to give the book a personal grounding. Curated with the intent to expand the way we think about women and psychosis, the contributors to this collection recognize that “voices and visions” do not occur in a vacuum, but are experienced within, and are influenced by, particular socio-cultural contexts.
This is the first book to address the clinical and neurobiological interface between schizophrenia and obsessive-compulsive disorder (OCD). There is growing evidence that obsessive-compulsive symptoms in schizophrenia are prevalent, persistent and characterized by a distinct pattern of familial inheritance, neurocognitive deficits and brain activation. This text provides guidelines for differential diagnosis of schizophrenic patients with obsessive-compulsive symptoms, and patients with primary OCD alongside poor insight, psychotic features or schizotypal personality. Written by a leading expert in the coexistence of obsessive-compulsive and schizophrenic phenomena, Schizo-Obsessive Disorder uses numerous case studies to present diagnostic guidelines and to describe a recommended treatment algorithm, demystifying this complex disorder and aiding its effective management. The book is essential reading for psychiatrists, neurologists and the wider range of multidisciplinary mental health practitioners.
H. HAFNER and W. F. GATTAZ Between 1891 and 1955, three founders of modern psychiatry, Emil Kraepelin (1856-1926), Karl Jaspers (1883-1969) and Kurt Schneider (1887-1967) lectured at the University of Heidelberg: Kraepelin for 12 years, Jaspers for over 25 years and Schneider for approximately 10 years. During this period they laid the foundations of descriptive psychopathology and modern classification and con tributed essentially to the development of our current thinking on schizophrenia. In 1986, on the occasion of the 600th anniversary of the University of Heidel berg, we held a symposium in memory of these three "giants of psychiatry" for which we chose the title "Search for the Causes of Schizophrenia". It was jointly organized by the Central Institute of Mental Health in Mannheim and the Department of Psychiatry of the University of Heidelberg. The intention was to meet one of the major challenges of current psychiatric research, namely the fact that since Kraepelin's masterly description of "Dementia praecox" (1894) and E. Bleuler's slightly different definition of schizophrenia (1911), we have made only insufficient advances in clarifying the aetiology of this frequent and still often dis abling mental disease.
The understanding of how to reduce risk factors for mental disorders has expanded remarkably as a result of recent scientific advances. This study, mandated by Congress, reviews those advances in the context of current research and provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction. Highlighting opportunities for and barriers to interventions, the book draws on successful models for the prevention of cardiovascular disease, injuries, and smoking. In addition, it reviews the risk factors associated with Alzheimer's disease, schizophrenia, alcohol abuse and dependence, depressive disorders, and conduct disorders and evaluates current illustrative prevention programs. The models and examination provide a framework for the design, application, and evaluation of interventions intended to prevent mental disorders and the transfer of knowledge about prevention from research to clinical practice. The book presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.