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The Science of Synthesis Editorial Board, together with the volume editors and authors, is constantly reviewing the whole field of synthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Several annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology.
The Science of Synthesis Editorial Board, together with the volume editors and authors, is constantly reviewing the whole field of synthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Four annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology.
The Science of Synthesis Editorial Board, together with the volume editors and authors, is constantly reviewing the whole field of synthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Several annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology.
The field of N-heterocyclic carbenes, whether in transition-metal catalysis or organocatalysis, is rapidly evolving towards applications, but is also still very active on the catalyst development front. Significant advances have been made over the past two decades and the development of these reactions has dramatically improved the efficiency of organic synthesis. N-Heterocyclic carbene based catalysts are now widely applied in the area of synthesis of both natural products and therapeutic agents. Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis presents the most commonly used and significant metal- or non-metal-catalyzed reactions for modern organic synthesis. The basic principles and current state-of-the-art of the methods are covered. Scope, limitations, and mechanism of these reactions are discussed and key experimental procedures are included. Typical examples of target synthesis are often provided to show the utility and inspire further applications.
This volume, the first of a two-volume set, provides a foundation for future research and development in science curriculum. Drawing upon complexity and systems theories, this book provides a framework for science curriculum that tackles and transform the interrelated and socio-ecological causes of our ecological crises in the Anthropocene. Chapters provide a foundational conceptual framework that can inspire and motivate educators and researchers alike, and push the boundaries of science curriculum research, theory, and practice The result is a refreshing and hopeful look at PK-12 science curriculum as a lever for positive change amidst our current global trajectory in the 21st century.
An introduction to a broad range of topics in deep learning, covering mathematical and conceptual background, deep learning techniques used in industry, and research perspectives. “Written by three experts in the field, Deep Learning is the only comprehensive book on the subject.” —Elon Musk, cochair of OpenAI; cofounder and CEO of Tesla and SpaceX Deep learning is a form of machine learning that enables computers to learn from experience and understand the world in terms of a hierarchy of concepts. Because the computer gathers knowledge from experience, there is no need for a human computer operator to formally specify all the knowledge that the computer needs. The hierarchy of concepts allows the computer to learn complicated concepts by building them out of simpler ones; a graph of these hierarchies would be many layers deep. This book introduces a broad range of topics in deep learning. The text offers mathematical and conceptual background, covering relevant concepts in linear algebra, probability theory and information theory, numerical computation, and machine learning. It describes deep learning techniques used by practitioners in industry, including deep feedforward networks, regularization, optimization algorithms, convolutional networks, sequence modeling, and practical methodology; and it surveys such applications as natural language processing, speech recognition, computer vision, online recommendation systems, bioinformatics, and videogames. Finally, the book offers research perspectives, covering such theoretical topics as linear factor models, autoencoders, representation learning, structured probabilistic models, Monte Carlo methods, the partition function, approximate inference, and deep generative models. Deep Learning can be used by undergraduate or graduate students planning careers in either industry or research, and by software engineers who want to begin using deep learning in their products or platforms. A website offers supplementary material for both readers and instructors.
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching. - Winner, 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association - Fully revised and updated throughout, and organized into 19 chapters for a more cogent and versatile presentation of concepts - Includes reaction examples taken from literature research reported between 2010-2015 - Features new full-color art and new chapter content on process chemistry and green organic chemistry - Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Solutions Manual for qualified course instructors
While research teams are producing relevant and valid knowledge for health promotion, there is not yet a structured manual and distinct field of health promotion research. This timely "state-of-the-art" handbook contributes to the structuring of such a field of research. This collection of original contributions explores the major epistemological, methodological, and ethical challenges facing health promotion research. It brings together experts from different "research traditions" that coexist in the field. The handbook covers the existing knowledge production and sharing practices to delineate the "discipline" and its agenda for future research. Ultimately, it contributes to the creation of a global community of health promotion researchers. The handbook is organized by four types of practices (what people actually do) studied in health promotion; the practices of: Individuals and populations in relation to their health and its determinants Professionals who intervene to improve population health Policy-makers and institutions involved in the advocacy, design, and implementation of policies and programs Researchers and innovators (academic scholars and global agencies) through which investment in research and production of evidence-based guidelines are made. Global Handbook of Health Promotion Research, Vol. 1: Mapping Health Promotion Research is a highly relevant reference tool for researchers and graduate students in health promotion, public health, education and socio-health sciences; practitioners in health, medical, and social sectors; policy-makers; and health research administrators.
Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.
The plant species that humans rely upon have an extended family of wild counterparts that are an important source of genetic diversity used to breed productive crops. These wild and weedy cousins are valuable as a resource for adapting our food, forage, industrial and other crops to climate change. Many wild plant species are also directly used, especially for revegetation, and as medicinal and ornamental plants. North America is rich in these wild plant genetic resources. This book is a valuable reference that describes the important crop wild relatives and wild utilized species found in Canada, the United States and Mexico. The book highlights efforts taken by these countries to conserve and use wild resources and provides essential information on best practices for collecting and conserving them. Numerous maps using up-to-date information and methods illustrate the distribution of important species, and supplement detailed description on the potential value these resources have to agriculture, as well as their conservation statuses and needs. There is broad recognition of the urgent need to conserve plant diversity; however, a small fraction of wild species is distinguished by their potential to support agricultural production. Many of these species are common, even weedy, and are easily overshadowed by rare or endangered plants. Nevertheless, because of their genetic proximity to agriculturally important crops or direct use, they deserve to be recognized, celebrated, conserved, and made available to support food and agricultural security. This comprehensive two-volume reference will be valuable for students and scientists interested in economic botany, and for practitioners at all levels tasked with conserving plant biodiversity. The chapters 'Public Education and Outreach Opportunities for Crop Wild Relatives in North America' and 'Genetic Resources of Crop Wild Relatives – A Canadian Perspective' are open access under a CC BY 4.0 license via link.springer.com.