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The third book in the trilogy--following "Fleet of Worlds" and "Juggler of Worlds--Destroyer of Worlds" is set 200 years before the discovery of Ringworld.
The Maya metropolis of Tikal was once one of the greatest cities in the world, its skyline dominated by huge temple-pyramids. In ad 750 over 100,000 people lived here, in the heart of the Guatemalan rainforest. Today Tikal is a popular site on the Maya tourist itinerary. But why did the city flourish? What does its history reveal about Maya civilization? And why did Tikal collapse? Drawing upon over 30 years of excavation and research, some of it his own, Peter D. Harrison gives a vivid account of the turbulent story of Tikal from 800 bc to the late 9th century ad. Strategically located, the city was a trade centre, an architectural pioneer and a focal point of warfare. The apogee of power and wealth was achieved during the reign of the Jaguar Claw clan, who built the Great Temples, some with tombs of treasures that hint at the richness of life of the lords of Tikal. Illustrated with photographs of artefacts and objects found at the site, remaining structures and a reconstruction of a Tikal king in full regalia, Peter D. Harrison offers a summary of what is known to date of this romantic, mysterious city and its rulers.
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
Given the latest advances in cancer research, which includes basic research and its derived diagnostic, clinical, and therapeutic applications, the book New Trends in Cancer for the 21st Century is written by individuals such as molecular biologists, whose tasks are to decipher, after sequencing the human genome, those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumor; and clinical oncologists, who treat patients. Pharmacogenetics introduces new perspectives in the translational fields with the design of drugs against specific targets, which at this moment are in clinical trials phases. This book achieves a state of the art in every field of cancer research and discusses the new perspectives that will open the future for cancer treatment (basic research, new technologies, new drugs, therapies...). For this reason, the book is intended for pathologists, clinicians, and biologists, as well as fellows and students of physiology and medicine.
In the post-meltdown world, it is irresponsible, ineffective, and ultimately useless to have a serious economic debate without considering and challenging the role of the Federal Reserve. Most people think of the Fed as an indispensable institution without which the country's economy could not properly function. But in End the Fed, Ron Paul draws on American history, economics, and fascinating stories from his own long political life to argue that the Fed is both corrupt and unconstitutional. It is inflating currency today at nearly a Weimar or Zimbabwe level, a practice that threatens to put us into an inflationary depression where $100 bills are worthless. What most people don't realize is that the Fed -- created by the Morgans and Rockefellers at a private club off the coast of Georgia -- is actually working against their own personal interests. Congressman Paul's urgent appeal to all citizens and officials tells us where we went wrong and what we need to do fix America's economic policy for future generations.
* Dotted * Size: 6 x 9" * Notebook * Journal * Planner * Dairy * 110 Pages * Classic White Dot Grid Paper * For Writing, Sketching, Journals and Hand Lettering * Great and reasonable Birthday, Christmas or Anniversary Gift Idea * Perfect for both travel and fitting right on your bedside table