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Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.
Salivary glands are of utmost importance for several physiological functions ranging from the protection of teeth and surrounding soft tissues to the lubrication of the oral cavity, which is crucial for speech and perception of food taste. This publication highlights specific aspects of salivary gland development, investigating the mechanisms involved in embryonic development, the current research in stem cells, the ability of adult glands to regenerate and the signalling pathways involved in this process. Key stages of salivary gland development, moving from initiation to differentiation of the glands, are discussed, as well as unusual adaptations, ranging from making silk to making venom. The book finally provides new data on surgical techniques and diagnostic tools for clinicians involved in salivary gland disorders. Researchers and students with an interest in craniofacial sciences as well as clinicians dealing with salivary gland disorders will find this publication an excellent source of up-to-date information.
Co-edited by Eugene N. Myers, a world-famous expert in the field, this has got to be the last word on salivary gland disorders. The disorders themselves cover a broad array of diseases, both benign and malignant. Thus, the contents of this book have been organized to reflect the diverse nature of salivary gland anatomy, physiology, and dysfunction in various states of disease. In this way, the evolution of the field and its diagnostic and therapeutic management are better demonstrated. Covering everything from practical diagnosis to gland tumor therapy, this really is a crucial work for any surgeon working in the facial or neck regions.
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Presenting the status of the fields of oral medicine and clinical oral pathology, this text also outlines the dentist's role in the management of patients with severe medical problems. It reflects the dramatic alterations in some disease patterns as well as the medical advances, which have made an impact on the field of oral medicine. Focusing on knowledge of the pathogenesis and management of diseases, it stresses new diagnostic techniques as well as new concepts of therapy. Chapter topics include the significant research in the field of facial pain management and the impact in oral medicine of such diseases as asthma, chronic obstructive pulmonary disease and tuberculosis. Also examined is the growing importance of geriatrics in dentistry and the issues of Alzheimer's, Parkinson's disease and elderly patients receiving multiple medications. The book includes a CD-ROM with complete text and illustrations.
Addressing controversial and topical issues in the field of salivary gland disease and surgical management of salivary gland disease, this new edition integrates the newest clinical findings with the historical pathological records, and attempts to resolve any conflicts between the two. Fully-illustrated and updated since the first edition in 2002, it is particuarly useful for trainees sitting their final exam, because it deals with new controversial subjects which are topical at all the conferences and exam vivas.
Full-color photomicrographs of disease pathology Here is a complete reference on the fundamental science, treatment, and management of salivary gland disorders. Covering anatomy, physiology, histology, cytology, pathology, and imaging, this text is a premier resource for physicians who diagnose and treat salivary gland diseases both medically and surgically. Highlights: Comprehensive review of both the common and unusual salivary gland disease entities in the adult and child Full-color histologic, cytologic, and pathologic photomicrographs help the clinician gain a full understanding of disease More than 200 line drawings and images demonstrate key steps in every surgical technique described Discussion of the new and emerging techniques of sialendoscopy, IMRT, and de-novo tissue engineering of functional salivary gland tissue Otolaryngologists, head and neck surgeons, oral surgeons, plastic surgeons, general surgeons, radiation oncologists, and pathologists will benefit from this exceptional text.
This book, written by world authorities in the field, is a comprehensive, up-to-date guide to the specialty of Oral Medicine, which is concerned with the diagnosis, prevention, and predominantly non-surgical management of medically related disorders and conditions affecting the oral and maxillofacial region. The pathophysiology, clinical presentation, diagnostic evaluation, and treatment of all relevant diseases and disorders are described with the aid of a wealth of clinical cases and illustrations that enable the reader to appreciate the diversity and potential complexity of Oral Medicine. In addition to the wide-ranging coverage of oral conditions, separate sections are devoted to bone and cutaneous pathology and to orofacial pain and its management, in addition to dental sleep medicine. The clinician who treats Oral Medicine patients will find this book to be an excellent aid to optimal management grounded in a sound knowledge of basic science and the dental and medical aspects of each disorder. In addition, it will serve as an outstanding textbook for undergraduate and postgraduate students.
Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflects the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease.