Download Free Roles Of Growth Hormone And Insulin Like Growth Factor I In Mouse Postnatal Development Book in PDF and EPUB Free Download. You can read online Roles Of Growth Hormone And Insulin Like Growth Factor I In Mouse Postnatal Development and write the review.

Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.
This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
The somatotropic axis is one of the major hormonal systems regulating growth, development, and metabolism. Growth hormone (GH) can act directly on target tissues or indirectly by stimulating insulin-like growth factor (IGF-I) through the JAK2-Stat5 pathway. The first objective of this dissertation was to test whether exogenous GH could stimulate growth, development, and insulin resistance in the absence of functional Stat5 proteins. Wild type (WT) and Stat5 mutant (Stat5DN) mice were treated with exogenous GH for 4 weeks. Stat5DN mice grew at a slower rate and had lower hepatic IGF-I expression and plasma IGF-I than WT animals. GH stimulated growth in WT animals but had absolutely no effect in Stat5DN mice. GH increased hepatic IGF-I expression and plasma IGF-I in WT mice but failed to do so in Stat5DN mice. GH-stimulated IGF-I expression also occurred in the muscle and adipose of WT mice only. GH-treated Stat5DN mice were protected from GH-induced insulin resistance. This protection was associated with lack of GH-stimulated expression of p85a mRNA in insulin sensitive tissues. GH plays a critical role in mammary development through its modulation of mammary production of IGF-I and IGF binding proteins (IGFBPs). One component of the IGF system that has not been studied in mammary development is the acid labile subunit (ALS). ALS is thought to function exclusively by forming ternary complexes with IGF-I and IGFBP-3 or -5 to build a reservoir of circulating IGF-I. The second objective was to evaluate the role of ALS in mammary gland development using null ALS mice. Null ALS mice had three specific mammary defects, namely delayed ductal elongation, impaired ductal branching in early pregnancy, and delayed involution following lactation. In contrast, mammary development during late ALS mRNA was pregnancy and lactation appeared normal in null ALS mice. detected in the mouse mammary gland, and levels of expression were comparable to liver during pregnancy, lactation, and involution. Therefore, mammary defects seen in null ALS mice cannot be attributed solely to disruption of the circulating IGF system and could relate partly to local ALS expression.
Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.
The gut not only represents the largest endocrine organ of the human body but is also profoundly involved in the control of metabolism through peptide hormones. Therefore, gastrointestinal hormones are acting via autocrine, paracrine, and classical endocrine pathways and regulate e.g. digestion, hunger, and satiety. Furthermore, they are important regulators of body weight, growth, and glucose metabolism, as well as of mood and behavior. Physicians and scientists in the field of pediatric endocrinology and diabetes, as well as in pediatric gastroenterology, require an extensive understanding of the origin of enteroendocrine cells, factors controlling their differentiation, hormone gene expression, secretion, function and, finally, the complex interaction with other organs, especially the central nervous system. In order to meet these needs, experts in the field have written up-to-date, comprehensive, and illustrated reviews presenting the current knowledge in the field of gastrointestinal endocrinology with a pediatric view. Those reviews comprise this latest volume of Endocrine Development.