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Over the last decade, the volume of research into the pathophysiology and genetics of pulmonary diseases has increased greatly. This has led to the development of new treatments and therapies for many diseases, including lung cancer, asthma and cystic fibrosis. This issue of the ERS Monograph comprehensively demonstrates the developments in respiratory medicine in recent years. It outlines the importance of epidemiology in respiratory medicine, and will prove a methodological tool that will help disease management. It should also be used as an advocacy tool for the sake of public health.
Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
This is a comprehensive and authoritative textbook on pediatric pulmonology. Edited by Pablo Bertrand and Ignacio Sánchez, renowned academics and pediatricians from the Pontifical Catholic University of Chile, it encompasses five sections and 74 chapters, presenting and discussing the most important topics related to pediatric respiratory diseases. Written and presented in a simple and didactic format, it intends to ease learning and settlement of doubts in pediatric respiratory diseases. The reader is naturally introduced into the physiology, diagnosis, syndromes, diseases and the treatment associated with the respiratory pathologies affecting children. The chapters include algorithms for the treatment of various syndromes and updated treatment proposals grounded in evidence-based medicine for more than 50 pulmonary diseases. Pediatric Respiratory Diseases – A Comprehensive Textbook is an essential reference for the proper clinical approach to respiratory diseases in children. It is intended for all interns, residents and fellows with interest in pediatric pulmonary medicine, as well as practicing physicians, general practitioners, pediatricians and pulmonologists who face pediatric respiratory disorders in daily clinical practice.
This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Cons