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THE US EDITION OF THE INTERNATIONAL BESTSELLER A momentous medical breakthrough —a scientifically proven program for managing and reversing Type 2 Diabetes at any stage of health. The fastest growing disease in the world, Type 2 diabetes has long been regarded as an incurable, lifelong condition that becomes progressively worse over time, resulting in pain, loss of vision, amputation, and even premature death. But there is hope. For more than four decades, Dr. Roy Taylor has been studying the causes of diabetes. In 2017, he had a breakthrough: he found scientific proof that Type 2 diabetes is not only reversible, but that anyone following a simple regimen can prevent and cure it. Dr. Taylor’s research shows that Type 2 diabetes is caused by too much fat in the liver and pancreas, which interferes with both organs’ normal functioning. By losing less than 1 gram of fat, the liver and organ can begin to perform as they were designed to once again—thus beginning the reversal process. The most efficient way to shed fat from the liver and pancreas is to lose weight as quickly as possible. Life Without Diabetes makes it easy for people to cut back on their daily calorie intake and avoid the two big problems of dieting—hunger and choice—and lose up to 35 pounds in just eight weeks. Thanks to Dr. Taylor, we can now fundamentally change how we treat and prevent this debilitating and all-too-common disease forever.
A practical "how to" guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006 Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced – and are being developed further – that facilitate monitoring of metabolism and even diagnosis of certain defects in human metabolism. While some of these methods are restricted to research facilities, others are already used in clinical practice. The correct beneficial use of these methods requires knowledge of the nature of the techniques and their clinical relevance. Clinical Diabetes Research: Methods and Techniques provides summaries of established state-of-the art-techniques and introduces the new technologies, evaluating their potential in clinical diabetes research. One section compares the efficacy of all metabolic tests that measure insulin action. Another section describes methods that allow quantification of whole body and intracellular metabolic fluxes relevant to diabetes research. The final section focuses on the planning and pitfalls of clinical studies in the field of metabolism. Each chapter throughout the book combines the theoretical basis of the approach with practical recommendations. There are further chapters on the design of clinical trials and ethical considerations. The publication is timely in view of the impressive development of the methods and techniques with their application to understanding the pathophysiology of diabetes, insulin resistance syndromes, obesity, and the metabolic effects of treatment. Clinical Diabetes Research: Methods and Techniques is of great relevance for researchers (from students and post-docs to principal investigators) in the field of human metabolism, clinical endocrinologists and diabetologists who are involved in clinical studies.
In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular BiologyTM series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.
This book provides a unique and comprehensive synopsis of the prevention and early diagnosis of Type 2 Diabetes. It features articles by key opinion leaders in diabetes from North America, Europe and the Asia-Pacific region who describe the gravity of the problem and the important issue of screening, including contributions on the perspectives of the International Diabetes Federation and the World Health Organization. Once patients at risk have been identified, the key issue is to prevent their progression to full-blown diabetes. Several chapters address this, particularly the difficult task of changing people’s behaviour. Prevention of the complications associated with diabetes involves more targeted interventions, which are discussed by experts in the relevant areas. This book offers both a global perspective and local solutions. Key contributors include Paul Zimmet and Pierre Lefèbvre, President of the International Diabetes Federation who has written a chapter and a foreword. Praise from the reviews: "[A]n excellent resource for professionals who want a good means for getting up to speed on the prevention angle. It is all-inclusive from many perspectives – authorship of chapters, rich reference lists, and content (...). This book is a one-stop source for understanding the state of current prevention knowledge about type 2 diabetes." —DIABETES TECHNOLOGY & THERAPEUTICS "This is a timely and helpful treatment of an important public health topic. I am unaware of any other contemporary books which address exactly this issue." —DOODY'S HEALTH SERVICES "An ambitious title, written by some of the world’s leading diabetologists, it takes a very careful approach ( ...)" —PEDIATRIC ENDOCRINOLOGY REVIEWS (PER)
This volume is the proceedings of the 7th Mathematical Modeling in Experimental Nutrition Conference held at Penn State University July 29 until August 1, 2000. The book addresses the determination of optimal intakes of nutrients and food components to provide lifelong health and reduce incidence of disease. Mathematical modelling provides a means of rigorously defining the functions of a system and using a variety of conditions to stimulate responses. This volume presents the newest advances in modelling and related experimental techniques required to meet the new challenges currently facing nutrition and biological science.
FROM NEW YORK TIMES BESTSELLING AUTHOR DR. JASON FUNG • “The doctor who invented intermittent fasting.” —The Daily Mail “Dr. Fung reveals how [type 2 diabetes] can be prevented and also reversed using natural dietary methods instead of medications … This is an important and timely book. Highly recommended.” —Dr. Mark Hyman, author of The Pegan Diet “Dr. Jason Fung has done it again. … Get this book!” —Dr. Steven R. Gundry, author of The Plant Paradox Everything you believe about treating type 2 diabetes is wrong. Today, most doctors, dietitians, and even diabetes specialists consider type 2 diabetes to be a chronic and progressive disease—a life sentence with no possibility of parole. But the truth, as Dr. Fung reveals in this groundbreaking book, is that type 2 diabetes is reversible. Writing with clear, persuasive language, Dr. Fung explains why conventional treatments that rely on insulin or other blood-glucose-lowering drugs can actually exacerbate the problem, leading to significant weight gain and even heart disease. The only way to treat type 2 diabetes effectively, he argues, is proper dieting and intermittent fasting—not medication. “The Diabetes Code is unabashedly provocative yet practical ... a clear blueprint for everyone to take control of their blood sugar, their health, and their lives.”—Dr. Will Cole, author of Intuitive Fasting
During the last few years, interest in research on the progression of chronic renal diseases has grown to the extent that this field is now in the mainstream of investigative nephrology. This interdisciplinary volume brings together the latest data from institutes at the forefront of current research. The contents cover a diverse range of topics including apoptosis in renal modeling and remodeling, the role of cytokines, growth factors and macrophages, the metabolism of interstitial collagen and collagenous materials, diabetic nephropathy, and vasoactive substances in renal injury. The use of methodology from morphometry to DNA recombinant technology illustrates the wide range of experimental approaches being adopted. Stimulating and up-to-date, this book is essential reading for nephrologists, biochemists, molecular biologists and all investigators interested in the mechanisms of renal disease progression.
This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.