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Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior-concepts familiar to physicists and chemists-are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions-and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.
Scientists have long desired to create synthetic systems that function with the precision and efficiency of biological systems. Using new techniques, researchers are now uncovering principles that could allow the creation of synthetic materials that can perform tasks as precise as biological systems. To assess the current work and future promise of the biology-materials science intersection, the Department of Energy and the National Science Foundation asked the NRC to identify the most compelling questions and opportunities at this interface, suggest strategies to address them, and consider connections with national priorities such as healthcare and economic growth. This book presents a discussion of principles governing biomaterial design, a description of advanced materials for selected functions such as energy and national security, an assessment of biomolecular materials research tools, and an examination of infrastructure and resources for bridging biological and materials science.
Convergence of the life sciences with fields including physical, chemical, mathematical, computational, engineering, and social sciences is a key strategy to tackle complex challenges and achieve new and innovative solutions. However, institutions face a lack of guidance on how to establish effective programs, what challenges they are likely to encounter, and what strategies other organizations have used to address the issues that arise. This advice is needed to harness the excitement generated by the concept of convergence and channel it into the policies, structures, and networks that will enable it to realize its goals. Convergence investigates examples of organizations that have established mechanisms to support convergent research. This report discusses details of current programs, how organizations have chosen to measure success, and what has worked and not worked in varied settings. The report summarizes the lessons learned and provides organizations with strategies to tackle practical needs and implementation challenges in areas such as infrastructure, student education and training, faculty advancement, and inter-institutional partnerships.
A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
The National Research Council (NRC) has been conducting decadal surveys in the Earth and space sciences since 1964, and released the latest five surveys in the past 5 years, four of which were only completed in the past 3 years. Lessons Learned in Decadal Planning in Space Science is the summary of a workshop held in response to unforseen challenges that arose in the implementation of the recommendations of the decadal surveys. This report takes a closer look at the decadal survey process and how to improve this essential tool for strategic planning in the Earth and space sciences. Workshop moderators, panelists, and participants lifted up the hood on the decadal survey process and scrutinized every element of the decadal surveys to determine what lessons can be gleaned from recent experiences and applied to the design and execution of future decadal surveys.
NASA proposed to make a hardware contribution to the European Space Agency's (ESA's) Euclid mission in exchange for U.S. membership on the Euclid Science Team and science data access. The Euclid mission will employ a space telescope that will make potentially important contributions to probing dark energy and to the measurement of cosmological parameters. Euclid will image a large fraction of the extragalactic sky at unprecedented resolution and measure spectra for millions of galaxies. Assessment of a Plan for U.S. Participation in Euclid evaluates whether a small investment in Euclid (around $20 million in hardware) is a viable part of an overall strategy to pursue the science goals set forth in New Worlds, New Horizons in Astronomy and Astrophysics, a decadal plan for ground- and space- based astronomy and astrophysics. The top-ranked large-scale, space-based priority of the New Worlds, New Horizons is the Wide-Field Infrared Survey Telescope (WFIRST). WFIRST has a broad, wide-field, near-infrared capability that will serve a wide variety of science programs of U.S. astronomers, including exoplanet research, near-infrared sky surveys, a guest observer program, and dark energy research. In carrying out this study the authoring committee's intent has been to be clear that this report does not alter New Worlds, New Horizon's plans for the implementation of the survey's priorities. Assessment of a Plan for U.S. Participation in Euclid concludes that the NASA proposal would represent a valuable first step toward meeting one of the science goals (furthering dark energy research) of WFIRST. While WFIRST dark energy measurements are expected to be superior to Euclid's, U.S. participation in Euclid will have clear scientific, technical, and programmatic benefits to the U.S. community as WFIRST and Euclid go forward. According to this report, the current NASA proposal, to invest modestly in Euclid, is consistent with an expeditious development of WFIRST and the achievement of the broader, and more ambitious, goals outlined in New Worlds, New Horizons. Knowledge gained from the Euclid project could help optimize the science return of the WFIRST mission as well. Such an investment will further the goals of New Worlds, New Horizons, be helpful to the preparations for WFIRST, and enhance WFIRST's chances of success.