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Nazi Submarines? Life-and-death battles with huge rats? The Cuban Missile Crisis? The assassination of JFK? These are not the predictable topics you'd typically associate with a book that appears to be about cleaning up toxic, abandoned industrial sites, urban redevelopment, economic growth, and job creation. But if your name is Bob White, they're all part of an improbable journey from naive farm boy, to Cold War-era U.S. Marine, to the executive directorship of the Redevelopment Authority of the County of Bucks. He's been referred to as "a beefy, fast-talking construction expert," a "larger-than-life visionary," "a superstar in economic development," and numerous other glowing accolades by Bucks County's press, politicians, and redevelopment and real estate industry executives. There's good reason for that: During Bob White's tenure at the helm of Bucks County's Redevelopment Authority, more than 50 large-scale, transformative projects were completed and over 20,000 jobs were saved or generated in the process. Dozens of environmentally contaminated, blighted buildings-relics from the county's past glory years as a major East Coast manufacturing center-were replaced by beautiful parks, sparkling office complexes, research centers, upscale residential communities, new roadways, and a thriving deepwater port. Repurposing the Past is HGTV on an industrial scale. In addition to Bob's unique and inspiring story, this new and unique book gives you a ringside seat to several dozen of his most significant, far-reaching projects. More than 80 photos provide a before and after look at each site, along with a narrative depicting its history, the environmental challenges and remediations involved, and the demolitions, budgets, grants, redevelopment plans, and community and political participation that helped Bucks County boldly step into the 21st century. Whether you're a student or a professional in the fields of environmental sciences, economic development, and urban studies, or you're simply looking to read a unique, inspiring story, Repurposing the Past will prove to be a page turner.
For many of us, our home is the center of our life. It is the place where our families meet and mingle, where we share our meals and share our dreams. So much more than just a space to live, our homes offer us a place of comfort, nourishment, and love for us and for our children. In Handmade Home, Amanda Blake Soule, author of The Creative Family and the blog SouleMama.com, offers simple sewing and craft projects for the home that reflect the needs, activities, and personalities of today’s families. As Amanda writes in the introduction, "As a crafter, I’m always looking for the next thing I want to make. As a mama, I’m always looking for the next thing we need—to do, to have, to use—as a family. The coming together of these parts is where the heart of Handmade Home lies." Filled with thirty-three projects made by reusing and repurposing materials, all of the items here offer a practical use in the home. From picnic blankets made out of repurposed bed sheets to curtains made out of vintage handkerchiefs, these projects express the sense of making something new out of something old as a way to live a more financially pared-down and simple life; lessen our impact on the earth; connect to the past and preserve a more traditional way of life; and place value on the work of the hands. Also included are projects that children can help with, allowing them to make their own special contribution to the family home. More than just a collection of projects for handmade items, this book offers the tools to create a life—and home—full of beauty, integrity, and joy. Projects include: • Papa’s Healing Cozy: This hot water bottle cover becomes a simple way to offer comfort to a sick child • Baby Sling: A simple pattern for an object that offers so much to a small child—refuge from the world and a place to lay their head next to a parent’s heart • Beach Blanket To-Go: Repurpose old sheets to create the perfect picnic blanket for special outdoor meals • Cozy Wall Pockets: A creative solution for storing a child’s small treasures Pattern templates for Handmade Home
How to reimagine existing buildings to create a more sustainable future The construction and operation of buildings is responsible for 41 percent of all primary energy use and 48 percent of all carbon emissions, and the impact of the demolition and removal of an older building can greatly diminish the advantages of adding green technologies to new construction. In Building Reuse, Kathryn Rogers Merlino makes an impassioned case that truly sustainable design requires reusing and reimagining existing buildings. Additionally, Merlino calls for a more expansive view of preservation that goes beyond keeping only the most distinctive structures based on their historical and cultural significance to embrace the creative reuse of even unremarkable buildings for their environmental value. Building Reuse includes a compelling range of case studies—from a private home to an eighteen-story office building—all located in the Pacific Northwest, a region with a long history of sustainable design and urban growth policies that have made reuse projects feasible. Reusing existing buildings can be challenging to accomplish, but changing the way we think about environmentally conscious architecture has the potential to significantly reduce energy consumption, carbon emissions, and waste.
Repurposing Legacy Data: Innovative Case Studies takes a look at how data scientists have re-purposed legacy data, whether their own, or legacy data that has been donated to the public domain. Most of the data stored worldwide is legacy data—data created some time in the past, for a particular purpose, and left in obsolete formats. As with keepsakes in an attic, we retain this information thinking it may have value in the future, though we have no current use for it. The case studies in this book, from such diverse fields as cosmology, quantum physics, high-energy physics, microbiology, psychiatry, medicine, and hospital administration, all serve to demonstrate how innovative people draw value from legacy data. By following the case examples, readers will learn how legacy data is restored, merged, and analyzed for purposes that were never imagined by the original data creators. - Discusses how combining existing data with other data sets of the same kind can produce an aggregate data set that serves to answer questions that could not be answered with any of the original data - Presents a method for re-analyzing original data sets using alternate or improved methods that can provide outcomes more precise and reliable than those produced in the original analysis - Explains how to integrate heterogeneous data sets for the purpose of answering questions or developing concepts that span several different scientific fields
The green belt has been one of the UK’s most consistent and successful planning policies. Over the past century, it has limited urban sprawl and preserved the countryside around our cities, but is it still fit for purpose in a world of unprecedented urban growth and potentially catastrophic climate change? Repurposing the Green Belt in the 21st Century examines the history of the green belt in the UK and how it has influenced planning regimes in other countries. Despite its undoubted achievements, it is time to review the green belt as an instrument of urban planning and landscape design. The problem of the ecological impact of cities and the mitigation measures of major climate changes are at the top of the urban agenda across the world. Urban agriculture, blue and green infrastructures, and forestation are the new ecological design imperatives driving urban policymaking.
Drug repurposing is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case; a holistic gedanken experiment almost needs to be undertaken at the very start of any repurposing development. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. And while repurposing of medicines has been in the mind of every doctor since Hypocrates, modern clinical practice will simply have to adapt to new repurposing techniques in an age where the number of known diseases is increasing much faster than the healthcare dollars available.
"Country Living contributing editor Randy Florke shows how to decorate and renovate a home inexpensively with repurposed, restored, and recycled materials. Providing inspiration and practical information, he perfectly captures why sustainable living is important and reveals how everyone can create a home that's a harmonious with the environment as it is beautiful. What's more, 'Restore. Recycle. Repurpose.' explains how to do it without buying costly materials from far-flung places or throwing out what you already have. Room by room, Florke presents ideas, examples, and resources that are "shades of green." His approach begins with a major focus for each room, such as vanities, sinks, and tubs in the bathroom. Sharing his flea market and thrift shopping skills as well as some savvy wisdom inspired by his grandmother, Florke will help you create a welcoming, lovely, earth-friendly décor--without spending a fortune"--P. [2] of cover.
Perfect for the do-it-yourselfer, this handy guide to household electronics gives the weekend workbench enthusiast a multitude of ideas on how to salvage valuable parts from old electronics and turn them into useful gadgets once more. This handbook is loaded with information and helpful tips for disassembling old and broken electronics. Each of the more than 50 deconstruction projects includes a "treasures cache" of the components to be found, a required tools list, and step-by-step instructions with photos on how to safely extract the working components. Projects include building a desk lamp from an old flatbed scanner, a barbeque supercharger from a Dustbuster impeller, and a robot from the gears, rollers, and stepper motor found in an ink-jet printer. Now, old VHS players and fax machines will find new life with these fun ideas.
Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.