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Diagnostic Atlas of Renal Pathology, by Agnes B. Fogo, MD and Michael Kashgarian, MD, delivers practical, highly visual guidance for effectively and accurately diagnosing a wide range of pathologic entities. More than 700 high-quality illustrations help you to recognize the pathologic features and clinical manifestations of both common and rare renal disorders and to formulate confident and accurate diagnoses. Thoroughly updated throughout, this companion to Brenner & Rector’s The Kidney, 9th Edition provides the newest information regarding categorizing and classification of diseases and describes how this relates to the various morphological lesions illustrated and their clinical significance. See more than 700 high quality representative images of light, immunofluorescence, and electron microscopy for each diagnostic entity with correlations to clinical presentation and pathogenesis. Easily locate in-depth information on any disease's clinical course and treatment by cross-referring companion text, Brenner & Rector’s The Kidney. Grasp key characteristic pathologic findings and prognostic, pathogenetic, and etiologic information through focused, detailed discussions. Make accurate, complete reports by fully understanding clinical correlations. Get an in-depth examination of pathophysiology, clinical presentations, and comprehensive references Keep current with the latest knowledge and evidence-based practices. Comprehensive updates throughout include a brand-new chapter on "Approaches to Chronic Kidney Disease" that includes coverage of Chronic Kidney Disease; Age-Related Sclerosis; Glomerular vs. Tubulointerstitial vs. Vascular Disease; and the differential diagnostic approach to Segmental Glomerulosclerosis lesions. Extensive updates to all previous chapters include new classifications of various diseases such as igA nephropathy, diabetic nephropathy, crescentic GN, and renal transplant rejection. Stay well informed about hot topics including acute phosphate nephropathy; new concepts in the pathogenesis of thrombotic microangiopathies and eclampsia; and new information relative to etiology and pathogenesis of podocytopathies. Quickly access the information you need thanks to a user-friendly format, tables and sidebars with key points and differential diagnoses, and chapters that include concise, templated discussions regarding the etiology and pathogenesis of the disorder.
Experts in the field of renal disease offer careful pathologic descriptions, appropriate clinical correlations, and extensive discussions on causes and pathogenesis to clarify the clinicians understanding and help facilitate easy, accurate diagnosis. This updated edition features hundreds of razor-sharp illustrations along with more international contributors than before.
Now in its second edition, the Oxford Handbook of Clinical Pathology is the concise and rapidly accessible guide to general pathologic principles, and the pathology behind common and important conditions across all the major medical and surgical specialties. Fully updated and now including a brand new chapter on head and neck pathology, this book continues to be the definitive resource for medical students and doctors with an interest in this important specialty. Authored by leading experts, The Oxford Handbook of Clinical Pathology uses the best-selling Oxford Handbook format to cover macroscopic and microscopic features alongside immunohistochemical and molecular pathology in a succinct and practical style. This edition is fully illustrated and now includes over new 50 full colour images and staging information for major malignancies to aid the reader and to explain the pathology of common conditions. This handbook continues to be an indispensable resource in the field for medical students, trainees, and biomedical scientists.
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Vor die Therapie setzten die Gotter die Diagnose. Otto NiigeJi Renal biopsy has decisively enriched renal diagnostics. Kidney diseases may be monitored during their entire course, and new techniques - such as immunofluorescence and electron microscopy - may be systematically applied, resulting in novel insights into the morphogenesis, pathogenesis, and etiology of kidney lesions. These insights, in turn, have served as new starting points, in the spirit of the quotation above, for the institution of causal therapy by the clinician. This work presents our findings based on 20 years of experience in evaluating renal biopsies. As of the end of 1974, our computer-supported, systematic clinical, morphologic, and follow-up evaluation of case material consisted of over 2000 biopsies, including 679 examined by electron microscopy and 400 by immunofluorescence microscopy. The subsequent 500 biopsies (400 studied by electron microscopy and 300 by immunofluorescence) were con sidered qualitatively only. In order to enhance qualitative findings with quantitative data, it was necessary to devise new methods for quantifying electron-microscopic findings. Additionally, we attempted to correlate cyto logic and immunofluorescent observations to integrate the isolated findings of electron microscopy into a vital cytologic pattern of reactions. We also attempted to evaluate the almost overwhelming flood of publications, especially those appearing within the last 10 years. The idea for this book was conceived a decade ago. At that time, however, our own experience in renal biopsy diagnostics seemed insufficient to sup port such a major undertaking.
Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach—from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.
The world's leading renal pathologists clearly and systematically identify The full spectrum of morphologic patterns encountered during renal biopsy interpretation. Strongly correlated with the clinical aspects of diagnosis, this hands-on text comprehensively reviews and interstitium, and vessels. It is an authoritative reference for the renal pathology newcomer and an essential reference for the experienced pathologist.
Fundamentals of Renal Pathology is a compact and up-to-date resource on the basics of renal pathology that will be of particular value for residents and fellows in training in renal pathology, general pathology, and nephrology, but will also serve as a handy reference for the more experienced. This second, revised and updated edition of the book offers an integrated approach based on contributions from established experts in the field. Key diseases are discussed within the context of clinical presentations, with the emphasis on clinicopathological correlation and differential diagnosis. Topics discussed include glomerular diseases with nephrotic or nephritic syndrome presentations; systemic and vascular diseases affecting the kidney, including diseases affecting the renal transplant; tubulointerstitial diseases; and plasma cell dyscrasias and associated diseases. Well-chosen color illustrations and electron micrographs enhance and complement the text.
This manual offers a concise guide for treating patients with a wide range of kidney disorders and hypertension. It features brief, focused chapters with abundant tables and algorithms. Coverage includes practical information on renal transplant and dialysis, the main classes of drugs used for hypertension and renal protection.