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FULL COLOR. 2nd Edition. 124 pages. A new way to understand relativity. Covers relativity from the simplest everyday situations, by easy stages, to more complex topics. There are lots of 'real-life' examples, illustrations and diagrams. All math is kept simple and fully explained. Some surprises await on relativity matters usually considered difficult to understand, but which are, in fact, Relatively Simple. Theoretical analysis includes: Basic Relativity; Starlight Aberration; Simultaneity; Ring Lasers; Galaxy Rotation and Pioneer 10 anomalous acceleration. For downloads (inc. free update of 1st Edition) and other works: search for Geoff Robinson at Lulu.com or direct via tinyurl.com/relativelysimple
'Outstanding Academic Title for 2014' by CHOICEEinstein Relatively Simple brings together for the first time an exceptionally clear explanation of both special and general relativity. It is for people who always wanted to understand Einstein's ideas but never thought they could.Told with humor, enthusiasm, and rare clarity, this entertaining book reveals how a former high school drop-out revolutionized our understanding of space and time. From E=mc2 and everyday time travel to black holes and the big bang, Einstein Relatively Simple takes us all, regardless of our scientific backgrounds, on a mind-boggling journey through the depths of Einstein's universe. Along the way, we track Einstein through the perils and triumphs of his life — follow his thinking, his logic, and his insights — and chronicle the audacity, imagination, and sheer genius of the man recognized as the greatest scientist of the modern era.In Part I on special relativity we learn how time slows and space shrinks with motion, and how mass and energy are equivalent. Part II on general relativity reveals a cosmos where black holes trap light and stop time, where wormholes form gravitational time machines, where space itself is continually expanding, and where some 13.7 billion years ago our universe was born in the ultimate cosmic event — the Big Bang.
Holistic medicine is: A clinical discipline that integrates both Eastern and Western medical methods and knowledge systems into one An evidence-based medicine that simultaneously embodies both a holistic approach and personalized principles The most straightforward form of medicine that adheres to scientific standards and effectively meets the needs of humanity In recent years, the integrated research on living organisms initiated by systems biology, along with the efforts of precision medicine to tailor treatment plans based on the individual characteristics of each patient, have opened up the process of modern biology and medicine returning to the ideas of Chinese medical traditions. Under the larger perspective of the development and evolution of Eastern and Western medicine, biology, and even natural science for hundreds of years, this book follows the evolution of modern scientific methods and reveals the inevitable trend of future medicine—holistic medicine. Holistic medicine is a medical system that fully integrates Chinese and Western medical methods and knowledge systems and conforms to scientific norms. It is an evidence-based medicine that embodies the holistic concept and individualized principles. This book outlines the method and theoretical framework of holistic medicine, and provides the method of constructing the theoretical system and using it to achieve the best regulation of diseases. It can be expected that holistic medicine will become the mainstream medicine in the 21st century.
In this authoritative volume you'll find today's most important molecular neurobiological advances and their relevance to clinicians treating patients with mental illness. Molecular Neurobiology for the Clinician, Review of Psychiatry, Volume 22, will update you on the latest findings -- and their impact on psychiatry. You'll learn about Discoveries with the potential to revolutionize your clinical approach by changing the ways in which you diagnose and treat patients The effects on psychiatry of advances in the molecular basis of neuronal network function, particularly in relation to abnormalities in cognitive and emotional regulation, and the identification of novel molecular targets for drug development How to apply these discoveries to diagnosing and treating major psychiatric disorders, including childhood- and adolescent-onset disorders, schizophrenia, drug addiction, and severe mood and anxiety disorders Molecular Neurobiology for the Clinician is an outstanding compilation of the best research by top names in the field. Psychiatrists, psychologists, psychiatric residents, and graduate students in neuroscience, psychiatry, and psychology will gain knowledge, understanding, and techniques for better diagnosis and treatment.
From Inception to The Lake House, moviegoers are increasingly flocking to narratologically complex puzzle films. These puzzle movies borrow techniques—like fragmented spatio-temporal reality, time loops, unstable characters with split identities or unreliable narrators—more commonly attributed to art cinema and independent films. The essays in Hollywood Puzzle Films examine the appropriation of puzzle film techniques by contemporary Hollywood dramas and blockbusters through questions of narrative, time, and altered realities. Analyzing movies like Source Code, The Butterfly Effect, Donnie Darko, Déjà Vu, and adaptations of Philip K. Dick, contributors explore the implications of Hollywood's new movie mind games.
Fundamental Theories of Mega Infrastructure Construction Management: Theoretical Considerations from Chinese Practices is a collection of decades of research and applications of managing megaprojects using theories of complex systems and management sciences. It presents basic (classical) theory of megaproject management and is a showcase of more than 30 years of research of complex system and management sciences on the theory of megaproject management resulting from the integrating of theory and practice of megaprojects. The theory and models have undergone rigorous systematic testing during the management and implementation of megaprojects in China. Megaprojects are huge undertakings, often in infrastructure (bridges, tunnels, airports, etc.) that involve huge levels of investment, often take years to complete, and typically run into delays, cost overruns, and any number of unforeseen problems. Over the last few decades, no one country has undertaken more of these projects than China, and this book presents the fundamental theories underlying the practice of Mega Infrastructure Construction Management as practiced in China. Individual chapters provide a basic definition of Mega Infrastructure Construction and it’s management; an overview of the theories behind it; the Formation Path; basic concepts; fundamental principles; scientific problems; the Method System of Meta-synthesis; specialized methods in research; and intelligent management of Mega Infrastructure Construction. Although the theoretical construction management problems in this book are derived from construction practices in China, they can be applied universally and extended for great fundamental significance.
Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at https://risccweb.csmc.edu/biostats/. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.
This book is just what it says it is: A theory of textuality divided into two parts, logical and epistemological.
The concept of regular extensions of an Hermitian (non-densely defined) operator was introduced by A. Kuzhel in 1980. This concept is a natural generalization of proper extensions of symmetric (densely defined) operators. The use of regular extensions enables one to study various classes of extensions of Hermitian operators without using the method of linear relations. The central question in this monograph is to what extent the Hermitian part of a linear operator determines its properties. Various properties are investigated and some applications of the theory are given. Chapter 1 deals with some results from operator theory and the theory of extensions. Chapter 2 is devoted to the investigation of regular extensions of Hermitian (symmetric) operators with certain restrictions. In chapter 3 regular extensions of Hermitian operators with the use of boundary-value spaces are investigated. In the final chapter, the results from chapters 1-3 are applied to the investigation of quasi-differential operators and models of zero-range potential with internal structure.
A Practical, Start-to-Finish Approach to Managing, Evolving, and Transforming Legacy IT Systems For every IT executive, manager, architect, program leader, project leader, and lead analyst “Richard and Kevin introduce us to a reality that’s often neglected in our industry: the problem of evolving legacy systems, a domain they call ‘Brownfield development.’ The authors identify the root of the problem as that of complexity, and offer an approach that focuses on the fundamentals of abstraction and efficient communication to nibble at this problem of transformation bit by bit. As the old saying goes, the way you eat the elephant is one bite at a time. Richard and Kevin bring us to the table with knife and fork and other tools, and show us a way to devour this elephant in the room.” Grady Booch, IBM Fellow, co-creator of UML “Most organizations in the 21st century have an existing, complex systems landscape. It is time that the IT industry face up to the reality of the situation and the need for new development methods and tools that address it. This book describes a new approach to the development of future systems: a structured approach that recognizes the challenges of ‘Brownfield’ development, is based on engineering principles, and is supported by appropriate tooling.” Chris Winter, CEng CITP FBCS FIET, IBM Fellow, Member of the IBM Academy of Technology Most conventional approaches to IT development assume that you’re building entirely new systems. Today, “Greenfield” development is a rarity. Nearly every project exists in the context of existing, complex system landscapes--often poorly documented and poorly understood. Now, two of IBM’s most experienced senior architects offer a new approach that is fully optimized for the unique realities of “Brownfield” development. Richard Hopkins and Kevin Jenkins explain why accumulated business and IT complexity is the root cause of large-scale project failure and show how to overcome that complexity “one bite of the elephant at a time.” You’ll learn how to manage every phase of the Brownfield project, leveraging breakthrough collaboration, communication, and visualization tools--including Web 2.0, semantic software engineering, model-driven development and architecture, and even virtual worlds. This book will help you reengineer new flexibility and agility into your IT environment...integrate more effectively with partners...prepare for emerging business challenges... improve system reuse and value...reduce project failure rates...meet any business or IT challenge that requires the evolution or transformation of legacy systems. · System complexity: understand it, and harness it Go beyond the comforting illusion of your high-level architecture diagrams · How conventional development techniques actually make things worse Why traditional decomposition and abstraction don’t work--and what to do instead · Reliably reengineer your IT in line with your business priorities New ways to understand, communicate, visualize, collaborate, and solve complex IT problems · Cut the elephant down to size, one step at a time Master all four phases of a Brownfield project: survey, engineer, accept, and deploy