Download Free Regulation Of Gene Expression In The Drosophila Olfactory System Varies Widely With Stimulus Duration Age And Development Book in PDF and EPUB Free Download. You can read online Regulation Of Gene Expression In The Drosophila Olfactory System Varies Widely With Stimulus Duration Age And Development and write the review.

The Drosophila olfactory system is an ideal model for the investigation of principles of gene regulation in the nervous system. Within this system, we characterize gene expression changes in response to short-term and long-term exposure to odorants. Additionally, we examine the contributions of two transcription factors to the development of this chemosensory system. Short-term exposure to odorants and light leads to neural activation and induction of activity regulated genes (ARGs). ARG induction in neurons in can lead to long-term changes at the level of the synapse. Such alterations in synaptic structure/function are thought to underlie important cellular processes such as synaptic plasticity and long-term memory formation. We have conducted a genome-wide study of genes in the Drosophila central nervous system induced after brief periods of sensory stimulation and have identified 352 genes whose ix expression increases in response to neural activity. The regulation of these genes is altered with increasing age. Furthermore, we demonstrate that loss of a histone deacetylase alters neuronal response to sensory stimuli, suggesting a mechanism of epigenetic regulation. We extended our transcriptome analysis to the fly antenna and found that the genes increased in response to fruit odorants differ significantly from the genes induced by the repellent DEET. In response to long-term exposure to the odorant diacetyl, we find that dramatic changes in gene expression can, in part, be attributed to inhibition of histone deacetylases. This non-traditional action of diacetyl slows neurodegeneration in the fly model for Huntington's Disease. We conclude with an analysis of two transcription factors acj6 and pdm3 and find they regulated proper chemosensory receptor and axon guidance gene expression in the developing Drosophila olfactory system.
Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.
Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
The behavior of insects transcends elementary forms of adaptive responding to environmental changes. We discuss examples of exploration, instrumental and observational learning, expectation, learning in a social context, and planning of future actions. We show that learning about sensory cues allows insects to transfer flexibly their responses to novel stimuli attaining thereby different levels of complexity, from basic generalization to categorization and concept learning consistent with rule extraction. We argue that updating of existing memories requires multiple forms of memory processing. A key element in these processes is working memory, an active form of memory considered to allow evaluation of actions on the basis of expected outcome. We discuss which of these cognitive faculties can be traced to specific neural processes and how they relate to the overall organization of the insect brain.
A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written
The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.
This textbook guides the medical student, regardless of background or intended specialty, through the anatomy and function of the human nervous system. In writing specifically for medical students, the author concentrates on the neural contributions to common diseases, whether neurological or not, and omits topics without clinical relevance.
Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. - Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field - Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine - Written at a verbal and technical level that can be understood by scientists and college students - Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials