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This book presents the state-of-art in regenerative procedures currently applied by aesthetic physicians, plastic surgeons and dermatologists. It is divided into two parts, the first of which provides a detailed introduction to aesthetic medicine and the aging process. The second part, in turn, addresses the current status of techniques and technologies with regard to autologous grafts, covering fat transfer, blood grafts, skin grafts and stem cells. The book examines the surgical applications of these grafts, as well as potential side effects and limitations. Therapy combinations and outcomes round out the coverage. Aesthetic physicians, plastic surgeons and dermatologists interested in performing regenerative procedures for aesthetic purposes will find this book to be a valuable guide.
Physicians are now in a position pro-actively to use stem cells and their growth factors to regenerate the human body. Within the field of aesthetics, regenerative medicine is being used to reverse the ageing of tissues and to repair scarring to an unprecedented level. This highly illustrated text from an internationally recognized expert in cosmetic procedures documents the procedures and results for patients.
This book is unique in focusing expressly on regenerative medicine in the aesthetic field. With the aid of more than 400 color pictures, it provides step-by-step descriptions of procedures that can be performed easily in the private practice. The number of people pursuing anti-aging and cosmetic procedures in order to achieve a youthful, healthy, or simply improved aspect is continually increasing. At the same time the available techniques and materials have undergone rapid innovation in terms of both safety and quality. The practitioner no longer looks just at the correction or camouflage of an unwanted feature but rather also aims to address the aging process itself. Regenerative medicine appears to provide a unique and unlimited opportunity in this context. Autologous fat grafting, adipose-derived stem cells, and autologous platelet-rich plasma represent just some of the attractive options that can be used for volume restoration and facial rejuvenation.
Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.
"New techniques in regenerative facial surgery are among the hottest topics in the world of aesthetics. Yet the terminology has been confusing, and no standards of treatment have been introduced into the field. Nanofat, injectable tissue replacement and regeneration, stromal vascular fraction, exosomes, platelet-rich plasma, and mechanical devices that minimally manipulate fat and blood to retrieve certain cells and cell-matrix aggregates are used in the management of facial aging. What all regenerative treatments have in common is the creation to some degree of neoangiogenesis, collagen and elastin remodeling, and immune modulation of inflammation. Regenerative facial surgery aims to restore and reconstruct youth by anatomic repositioning to address laxity, facial fat grafting to target volume losses, and a variety of newer, regenerative strategies to reverse sun damage and skin aging. The rapidly rising use of these promising techniques in facial surgery requires knowledge of how the facial anatomy changes during the aging process, how to diagnose the precise areas of fat and bone loss, and how to combine these exciting new regenerative approaches alone and in combination with skin care, lasers, energy-based devices, and surgery to not only aesthetically benefit the patient, but also to regenerate tissues, slow, and possibly even reverse some of the components of facial aging. This unique book brings readers the essentials of the clinical practice of regenerative facial surgery by some of the field's earliest pioneers"--
During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular BiologyTM series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs.
The Aesthetic Medicine: Art and Techniques provides step-by-step instructions in the procedures and techniques commonly employed in aesthetic medicine. The book is divided into four parts, the first two of which offer an introduction to aesthetic medicine and discuss preoperative assessment and treatment. Detailed guidance is then given on a wide range of cutaneous procedures, including the use of botulinum toxins, dermabrasion and microdermabrasion, cryotherapy, chemical peel skin resurfacing, laser treatments, mesotherapy, sclerotherapy, capacitive radiofrequency treatment, and the use of dermarollers. The final part of the book is devoted to techniques employed in shaping the face and body, such as breast and facial augmentation, penile enhancement, liposuction, and management of hair loss or excess hair. All procedures are depicted with the aid of numerous high-quality illustrations and color photographs. This book will serve as an excellent guide for both beginners and experienced practitioners.
This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.
Aesthetic or cosmetic gynecology is a rapidly expanding and much in demand field worldwide. This book covers all aspects of cosmetic gynecology in great details and interdisciplinary fields. It provides information and practical tips on the new evolving and fast growing branch of aesthetic and regenerative gynecology. The book covers basics along with illustrations, practical tips and troubleshooting points. Chapters include anatomy, physiology, pathology and comprehensive management of diseases in relation to cosmetic gynecology. The book explains the basics of techniques and devices used in this field such as several energy based and high tech devices like lasers, Hifu, HIFEM, their safety profile, scope and uses in an easy to understand language supported by illustrations. It also covers complications, controversies and medicolegal issues surrounding this field. The book includes chapters from national and international experts of each technique and helps in systematic evidence based learning. The book serves as a comprehensive book for postgraduates and consultants in gynecology, plastic surgery, dermatology, urogynecology, vascular surgery, general surgery, for cosmetologists and those interested in regenerative sciences.
This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.