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This exciting book examines how human tissues and cells are being exchanged, commodified and commercialized by new health technologies. Through a discussion of emergent global ‘tissue economies’ the author explores the social dynamics of innovation in the fields of tissue engineering and stem cell science. The book explores how regenerative medicine configures and conceptualizes bodies and argues that the development of regenerative medicine is a feminist issue. In Regenerating Bodies, Kent critically examines the transformative potential of regenerative medicine and whether it represents a paradigm shift from more traditional forms of biomedicine. The book shows that users of these technologies are gendered and women’s bodies are enrolled in the production of them in particular ways. So what is the value of a feminist bioethics for thinking about the ethical issues at stake? Drawing on extensive qualitative field research, Kent examines the issues around donation, procurement, banking and engineering of human tissues, and presents an analysis of the regulatory and policy debates surrounding these practices within Europe and the UK. The book considers the claims that regenerative medicine represents exciting possibilities for treating the diseases of ageing bodies, critically assessing what kind of futures are embodied in tissue and cell based therapies. It will be of interest to a wide range of scholars and students within the social sciences, in health technology studies, bioethics, feminist studies, and gender and health studies.
Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products.The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. - Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization - "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights - Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies
This book uses mixed methods to extend the concept of “wellbeing stocks” to refer to dynamic ways of working with others. It addresses metaphors and praxis for weaving together strands of experience. The aim of the wellbeing stocks concept is to enable people to re-evaluate economics and to become more aware of the way in which we neglect social and environmental aspects of life. The pursuit of profit at the expense of people and the environment is a central problem for democracy and governance. The vulnerability of cities is a symptom of the lack of balance between individual and collective needs. This book explores the potential for cities, specifically in the regions of Indonesia, Africa, and Australia, to become more productive as sites for food and water security through more creative use of technology. It highlights the need for partners that see food and security feasible at the household level if supports are provided at the community, national and international level. The book examines how these regions are affected by demographics, climate change and people movements, but also explores ways to establish an effective cultural ecosystem management.
The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.