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Get Insight on the Function of Supercomplexes in Biological SystemsRedox Proteins in Supercomplexes and Signalosomes is one of the first books to explore the key role played by redox proteins and their interaction network in a wide range of essential cellular processes in all domains of life. The book explains how the mitochondrial respiratory chai
This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
Cysteine, a sulfur-containing amino acid, is vital in preserving the redox potential of cells and is a crucial component of the antioxidant molecule glutathione. Cysteine is involved in numerous vital functions in the body and has been linked to several medical conditions such as cardiovascular disease, neurological disorders, diabetes, cancer, and kidney dysfunction. The objective of this book is to provide a comprehensive summary of the most recent insights on cysteine metabolism and its significance in different pathological conditions.
World’s population is projected to reach 9.7 billion in 2050 and 11.2 billion in 2100. To meet the food demands of the exponentially increasing population, a massive food production is necessary. Agricultural production on land and aquatic systems pose negative impacts on the earth’s ecosystems. Combined effects of climate change, land degradation, cropland losses, water scarcity and species infestations are major causes for loss of agricultural yields up to 25%. Therefore, the world needs a paradigm shift in agriculture development for sustainable food production and security through green revolution and eco-friendly approaches. Hence, agriculture practices must be sustained by the ability of farm land to produce food to satisfy human needs indefinitely as well as having sustainable impacts on the broader environment. The real agricultural challenges of the future as well as for today differ according to their geopolitical and socioeconomic contexts. Therefore, sustainable agriculture must be inclusive and have adaptability and flexibility over time to respond to demands for food production. Considering all these points, this book has been prepared to address and insights to generate awareness of food security and focuses on perspectives of sustainable food production and security towards human society. The book facilitates to describes the classical and recent advancement of technologies and strategies by sustainable way through plant and animal origin including, breeding, pest management, tissue culture, transgenic techniques, bio and phytoremediation, environmental stress and resistance, plant growth enhancing microbes, bio-fertilizer and integrated approaches of food nutrition. Chapters provide a new dimension to discuss the issues, challenges and strategies of agricultural sustainability in a comprehensive manner. It aims at educating the students, advanced and budding researchers to develop novel approaches for sustainability with environmentally sound practices.
This book focuses on the environmental property of minerals including mineralogical record of environmental changes, mineralogical influence on the environmental quality, mineralogical evaluation of the environment, mineralogical processing of environmental pollutants and interaction between minerals and microbes. Understanding of the environmental property of minerals is a good supplement to the traditional concept of “mineral”. By demonstrating plenty of case studies with easy-to-understand figures and tables, this book introduces the environmental effects of interaction between minerals and microbes, physiological and ecological effects of biomineralization, reductive precipitation property of iron sulfide minerals, photocatalytic reduction property of sphalerite, photocatalytic oxidation property of rutile, tubular structure property of chrysotile, tunnel structure property of K-feldspar tetrahedron, tunnel structure property of cryptomelane octahedron, nano property of cryptomelane, crystallization property of jarosite, interaction between semiconducting minerals and microbes, pathological mineralization of human body, mineralogical processing of inorganic pollutants, mineralogical degradation of organic pollutants, mineralogical purification of smoke-type pollutants, mineralogical evaluation of soil environmental quality, mineralogical prevention and control of waste pollutants and mineralogical processing of mine tailings. The book is written for environmental mineralogist as well as postgraduates majoring in environmental science.
This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.
The regulation of the phosphorylation/dephosphorylation process, resulting in “cellular switches” that monitor normal plant physiology, growth and development, has immense potential in crop systems. With much of the information in the nascent stages, coming largely from Arabidopsis and rice particularly, the use of cell biology, genetic screens, biochemical approaches aided by an omics approach should help unravel the detail functional information available about signaling pathways in plants. The regulation could be exploited to develop crop varieties better equipped to handle changing environments and enhance agricultural productivity. In the post-genomic era, one of the major challenges is investigation and understanding of multiple genes and gene families regulating a particular physiological and developmental aspect of plant life cycle. One of the important physiological processes is regulation of stress response, which leads to adaptation or adjustment in response to adverse stimuli. With the holistic understanding of the signaling pathways involving phosphatases, one gene family or multiple genes or gene families, plant biologist can lay a foundation for designing and generating future crops, which can withstand the higher degree of environmental stresses. Especially abiotic stresses, which are the major cause of crop loss throughout the world without losing crop yield and productivity. This book incorporates the contributions from leading plant biologists in the field of stress-mediated dephosphorylation by phosphatases as an important task to elucidate the aspects of stress signaling by functional genomic approaches.
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology,
Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases Teaches the essentials of the genetic basis of disease in each major endocrine organ system Offers expert advice from genetic counselors on how to use genetic information in counseling patients Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing