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Reactive oxygen species (ROS) which include free radicals, peroxides, singlet oxygen, ozone, and nitrogen monoxide and dioxide free radicals, is an area of intense research. This volume covers (1) the destruction of cellular function by ROS resulting in pathological states; (2) the protection by ROS of an organism against invading organisms that cause infections; and (3) the role of ROS in normal physiological processes. Designed for beginning graduate students, this book gives a concise overview of the field.
This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.
Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. - Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress - Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention - Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress - Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment
In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.
Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. - Edited by Nobel Laureate Louis J. Ignarro - Up-to-date therapeutic implications of nitric oxide research - Authored by world experts on nitric oxide - Detailed research of the biochemistry and synthesis of nitric oxide
This unique compilation of chapters reviews a broad range of topics at the cutting edge of hearing research. The authors include many of the top auditory scientists in the world as well as some of the brightest rising stars. Although the book obviously focuses on the exciting, revolutionary work being done with mice, the authors have made a strong
This up-to-date, comprehensive toxicology handbook is devoted to the effects of environmental pollution on fish. Fish species represent nearly half of all vertebrates and have become important sentinels for environmental contamination and model organisms for understanding adverse outcomes from exposures. This new edition is written by recognized experts, and it highlights the significant research progress in fish toxicology that has resulted from rapid technological developments in analytical, biochemical, and genomic sciences. The book: Discusses fundamental topics such as toxicokinetics in fishes, processes governing biotransformation within these organisms, and reactive oxygen species and oxidative stress. Explains key target organ systems for chemical impacts in fish, such as the nervous and immune systems, and how fishes can develop resistance to chemical toxicity. Covers multi-transgenerational effects on fishes, epigenetics, proteomics and metabolomics, and adverse outcome pathways. Replacing the case studies in the first edition, this update delves into the impacts of microplastics, pharmaceuticals, and oil spills in dedicated final chapters. With nearly 200 illustrations and tables, this comprehensive reference work presents concepts in a way that is useful for both novices to and experts in the field of fish toxicology.
Nanobiomaterials in Galenic Formulations and Cosmetics: Applications of Nanobiomaterials is one of the first books on the market related to the application of nanotechnology in galenic formulations and cosmetics. This book provides the results of current research for those working in an applied setting. The advantage of having all this information in one coherent text is the focused nature of the chapters and the ease of which this information can be accessed. This collection of titles brings together many of the novel applications these materials have in biology, and discusses the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment there is no other comparable book series covering all the subjects approached in this set of titles. - Offers an updated and highly structured reference material for students, researchers, and practitioners working in biomedical, biotechnological, and engineering fields - Serves as a valuable resource of recent scientific progress, along with most known applications of nanomaterials in the biomedical field - Features novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology
This book provides a detailed investigation into the evidence implicating oxygen radicals in the etiology of eleven different human diseases or conditions. World renowned experts from each discipline review the data supporting this involvement, and discuss the full implications that result. Topics covered include Alzheimer's disease, cerebral ischemia, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, ARDS, critical care medicine and cancer. This book not only provides an invaluable resource for those seeking up to date information on the evidence supporting the involvement of oxygen radicals in human disease, but also instigates theoretical discussion of future research endeavors.
Describes the basics of ROS metabolism in plants and examines the broad range of ROS signaling mechanisms New discoveries about the effects of reactive oxygen species (ROS) on plants have turned ROS from being considered a bane into a boon, because their roles have been discovered in many plant developmental processes as signaling molecules. This comprehensive book teaches about the role of ROS metabolism in plants and how they affect various developmental processes. It also discusses in detail the advancements made in understanding the ROS signaling. Reactive Oxygen Species in Plants: Boon Or Bane - Revisiting the Role of ROS begins by presenting the basic introduction to ROS and deciphers the detailed knowledge in ROS research. It then examines the broad range of ROS signaling mechanisms as well as how they may be beneficial for plants and human beings. This book also describes both the bane and boon aspects of ROS with their impact on plants, and how the recent revelations have compelled us to rethink ROS turning from stressors to plant regulators. ● Compiles, for the first time, the wholesome knowledge in ROS research and their cellular signaling ● Includes new discoveries and in-depth discussions about the advancements made in the field ● Discusses reactive oxygen species which are involved in a broad range of biological processes Reactive Oxygen Species in Plants: Boon Or Bane - Revisiting the Role of ROS will help scientists to utilize the functions of ROS signaling for plants and also enable readers to gain a deeper knowledge of ROS research and signaling. It is highly recommended for researchers, scientists, and academicians in plant science as well for advanced undergraduate and postgraduate students.