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Separated from her ship, Major Trace Thakur is stranded on the reeh-occupied world of Rando. The native corbi have suffered beneath reeh tyranny for 800 years, and many have given up hope. But Trace needs the data stored in the reeh's genetic technology and command center - the Rando Splicer - if she's to learn how to save humanity from impending disaster, and is planning an assault against overwhelming odds. She'll need help from the UFS Phoenix, though, which is caught in a ritual medieval battle to change the croma leadership that sees her crew embarking on a perilous journey across a warring desert continent. Should they fail, humanity could be just one of many species to die.
Upon the ancient drysine moon/city of Defiance, the UFS Phoenix is being rebuilt, but her crew cannot do so in peace. Parren factions jostle for control of not only Defiance, but of the drysine data-core that Phoenix won at such an awful price. But the parren do not lay sole claim to that ancient knowledge, and within the bowels of the machine-city, something long-dead is awakening.While aliens battle, Captain Debogande struggles to decide his next step. Human emissaries beckon him home, while a terrible new threat drives him toward the far edge of Spiral space. There live the croma, locked in a titanic struggle against the reeh, a species more terrifying than any yet faced by humanity. And holding perhaps the key to humanity's salvation are a small force of freedom fighters, waging a hopeless battle against impossible odds, having waited a thousand years for just such a saviour as the UFS Phoenix...
The legendary battle-carrier UFS Phoenix is on the run in Outer Neutral Space. Lieutenant Commander Erik Debogande and Major Trace Thakur are determined to use neutral territory to broker a peace between humanity's warring factions, away from Fleet's strong arm. But as machinations in Fleet Command send a legendary warrior from Trace's past on a sworn path to kill her, there arises in the territory of an insectoid foe an ancient enemy from the nightmares of Spiral history, bent on Phoenix's destruction....
One thousand years after Earth was destroyed in an unprovoked attack, humanity has emerged victorious from a series of terrible wars to assure its place in the galaxy. But during celebrations on humanity's new homeworld, the legendary Captain Pantillo of the battle carrier Phoenix is court-martialed then killed, and his deputy, Lieutenant Commander Erik Debogande, the heir to humanity's most powerful industrial family, is framed for his murder. Assisted by Phoenix's marine commander Trace Thakur, Erik and Phoenix are forced to go on the run as they seek to unravel the conspiracy behind their captain's demise, pursued to the death by their own fleet. What they discover about the truth behind the wars and the nature of humanity's ancient alien allies will shake the sentient galaxy to its core.
The UFS Phoenix embarks on a dangerous quest for the AI Ceephay Queen who rules at the heart of the Reeh Empire. For cover, Phoenix will use the enormous war being launched by the new rulers of the croma, Croma'Dokran, into reeh space. This war is intended in part to evacuate the corbi homeworld of Rando, thus righting a great wrong of croma history by rescuing two hundred million corbi from reeh tyranny.While Lisbeth defies her parren seniors to use drysine and parren firepower in assisting the evacuation, Erik captains Phoenix, accompanied by Styx's four drysine warships, to the world of Eshir, where Styx insists the Ceephay Queen was once located. There, in the ancient, ruined city of Qalea, Trace and Styx must lead an away mission through buried layers of Reeh Empire history to uncover its long-forgotten secrets. Discovering the Ceephay Queen's present location could set them on the road to saving humanity. But Qalea's secrets have been hidden by the reeh for millennia, secrets that could rock their Empire, and they will stop at nothing to keep hidden.
The UFS Phoenix is hunting for the long-lost drysine data-core. Within it lie the secrets to saving humanity from the resurgent deepynine machine-race. To recover it, Captain Erik Debogande must work together with the man who holds his sister hostage - the power-hungry parren leader Aristan. Aristan has sworn he will return Lisbeth Debogande once Phoenix grants him equal access to its prize. But now from the direction of hostile space comes word of a dark force hunting humans and parren alike, determined at all costs that the store of the lost Drysine Empire's knowledge should be possessed by neither...
The UFS Phoenix is on a mission to find a lost data-core that may contain the secret to defeating the alo-deepynine alliance. But the means to find the data-core is hidden deep in tavalai space, in a highest-security vault where the tavalai's manipulative State Department keep all their most treacherous secrets. To recover it, Phoenix must pull off the most daring heist the Spiral has ever seen. But Phoenix will need help -- in the form of a rebellious faction of the tavalai Fleet; a fanatical parren mystic who lusts mostly for power; a cynical old tavalai marine who's spent much of his life fighting humans; and a super-intelligent AI queen who will sacrifice anything to rescue her race from extinction. None of them can be trusted, and neither Captain Erik Debogande nor Major Trace Thakur are experienced in this kind of work. But each must gather their ingenuity and courage, and learn as they go, as the scale of the threat confronting humanity looms larger, and the clock is ticking...
Spurning her royal heritage to be raised by the great warrior, Kessligh, her exquisite swordplay astonishes all who witness it. But Sasha is still young, untested in battle and often led by her rash temper. In the complex world of Lenayin loyalties, her defiant wilfulness is attracting the wrong kind of attention. Lenayin is a land almost divided by its two faiths: the Verenthane of the ruling classes and the pagan Goeren-yai, amongst whom Sasha now lives. The Goeren-yai worship swordplay and honour and begin to see Sasha as the great spirit—the Synnich—who will unite them. But Sasha is still searching for what she believes and must choose her side carefully. When the Udalyn people—the symbol of Goeren-yai pride and courage—are attacked, Sasha will face her moment of testing. How will she act? Is she ready to lead? Can she be the saviour they need her to be?
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
A FULLY ILLUSTRATED, HUMOROUS GIFT BOOK FOR FANS OF THE ALIEN FRANCHISE Aboard the USCSS Nostromo, Jonesy leads a simple life enjoying The Company cat food and chasing space rodents. Until one day, his cryostasis catnap is rudely interrupted. The humans have a new pet and it's definitely not house-trained. In space, no one can hear you meow. This full-color, illustrated book offers a cat's eye view of all the action from the movie Alien. With new and original artwork by artist Rory Lucey, this is the perfect gift for all Alien fans (and cat lovers).