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It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: Early research on radioprotectors WR-2721, an aminothiol prodrug, as a radioprotector New results with naturally occurring thiols Nitroxides as effective radioprotectors in vitro and in vivo Radioprotection observed with radical scavengers or antioxidants Bone marrow radioprotection with cytokines and biological modifiers Multiple mechanisms of altering radiation response by eicosanoids Vascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosis Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.
It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: Early research on radioprotectors WR-2721, an aminothiol prodrug, as a radioprotector New results with naturally occurring thiols Nitroxides as effective radioprotectors in vitro and in vivo Radioprotection observed with radical scavengers or antioxidants Bone marrow radioprotection with cytokines and biological modifiers Multiple mechanisms of altering radiation response by eicosanoids Vascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosis Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.
In print since 1972, this seventh edition of Radiobiology for the Radiologist is the most extensively revised to date. It consists of two sections, one for those studying or practicing diagnostic radiolo, nuclear medicine and radiation oncology; the other for those engaged in the study or clinical practice of radiation oncology--a new chapter, on radiologic terrorism, is specifically for those in the radiation sciences who would manage exposed individuals in the event of a terrorist event. The 17 chapters in Section I represent a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA. The 11 chapters in Section II address more in-depth topics in radiation oncology, such as cancer biology, retreatment after radiotherapy, chemotherapeutic agents and hyperthermia. Now in full color, this lavishly illustrated new edition is replete with tables and figures that underscore essential concepts. Each chapter concludes with a "summary of pertinent conclusions" to facilitate quick review and help readers retain important information.
Discusses the potential of radiation countermeasure agents and radiosensitizers of herbal origin, and their multifaceted mode of action, particularly in nuclear operations, rescue operations, deep space missions, and application during radiotherapy. This book is suitable for readers in radiation biology, radiation oncology, and military medicine.
The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.
This handbook presents the most current information on the effects of ionizing radiation on mammalian cells, with emphasis on human tissues. The dose-effect relationship is emphasized in a quantitative manner. The book contains up-to-date data on the late effects of low levels of radiation on humans. It also provides some of the late consequences of radiation therapy detected among cancer survivors.
Human Radiation Injury is a concise but thorough presentation of known toxicities of radiation exposure in humans. This unique text is the only single reference available that studies the risks to humans from medical, environmental, and accidental or terrorist-related exposure to radiation. The chapters cover modern understanding of the molecular and cellular events involved in radiation injury, the known dose-effect relationships for human organ systems, and a full discussion of normal tissue toxicity related to therapeutic radiation. Recommended guidelines are outlined and the best available treatments following injury are also detailed. A companion website offers the fully searchable text and an image bank.
The updated Sixth Edition of this popular text will remain the first choice for those who need current, clinically relevant information on how radiation affects the human body. Written by practicing, active radiobiologists, the book brings together basic laboratory research and practical, clinical applications. The easy-to-read text and informative illustrations ensure comprehension, and summaries at the end of each chapter facilitate quick review. The first section covers topics applicable to diagnostic radiology, nuclear medicine, and radiation oncology; the second section offers material specifically for radiation oncologists. This edition includes new material about doses and risks in interventional radiology and cardiology.
This book discusses the efficacy of nanomaterial-based X-rays enhancers against cancer therapy and imaging in both in vitro and in vivo systems. Also, synthesis, mechanism, and the related biological effects are given. Moreover, nanoparticle-based contrast agents to enhance the image quality are compiled. Finally, special nanoparticle-based contrast agents to enhance the contrast for targeted cancer therapy are covered and discussed.
This book addresses the most relevant aspects of radiation oncology in terms of technical integrity, dose parameters, machine and software specifications, as well as regulatory requirements. Radiation oncology is a unique field that combines physics and biology. As a result, it has not only a clinical aspect, but also a physics aspect and biology aspect, all three of which are inter-related and critical to optimal radiation treatment planning. In addition, radiation oncology involves a host of machines/software. One needs to have a firm command of these machines and their specifications to deliver comprehensive treatment. However, this information is not readily available, which poses serious challenges for students learning the planning aspect of radiation therapy. In response, this book compiles these relevant aspects in a single source. Radiation oncology is a dynamic field, and is continuously evolving. However, tracking down the latest findings is both difficult and time-consuming. Consequently, the book also comprehensively covers the most important trials. Offering an essential ready reference work, it represents a value asset for all radiation oncology practitioners, trainees and students.