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This book is a printed edition of the Special Issue "Radiopharmaceutical Chemistry between Imaging and Radioendotherapy" that was published in Pharmaceuticals
The use of MATLAB® in clinical Medical Physics is continuously increasing, thanks to new technologies and developments in the field. However, there is a lack of practical guidance for students, researchers, and medical professionals on how to incorporate it into their work. Focusing on the areas of diagnostic Nuclear Medicine and Radiation Oncology Imaging, this book provides a comprehensive treatment of the use of MATLAB in clinical Medical Physics, in Nuclear Medicine. It is an invaluable guide for medical physicists and researchers, in addition to postgraduates in medical physics or biomedical engineering, preparing for a career in the field. In the field of Nuclear Medicine, MATLAB enables quantitative analysis and the visualization of nuclear medical images of several modalities, such as Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), or a hybrid system where a Computed Tomography system is incorporated into a SPECT or PET system or similarly, a Magnetic Resonance Imaging system (MRI) into a SPECT or PET system. Through a high-performance interactive software, MATLAB also allows matrix computation, simulation, quantitative analysis, image processing, and algorithm implementation. MATLAB can provide medical physicists with the necessary tools for analyzing and visualizing medical images. It is useful in creating imaging algorithms for diagnostic and therapeutic purposes, solving problems of image reconstruction, processing, and calculating absorbed doses with accuracy. An important feature of this application of MATLAB is that the results are completely reliable and are not dependent on any specific γ-cameras and workstations. The use of MATLAB algorithms can greatly assist in the exploration of the anatomy and functions of the human body, offering accurate and precise results in Nuclear Medicine studies. KEY FEATURES Presents a practical, case-based approach whilst remaining accessible to students Contains chapter contributions from subject area specialists across the field Includes real clinical problems and examples, with worked through solutions Maria Lyra Georgosopoulou, PhD, is a Medical Physicist and Associate Professor at the National and Kapodistrian University of Athens, Greece. Photo credit: The Antikythera Mechanism is the world’s oldest known analog computer. It consisted of many wheels and discs that could be placed onto the mechanism for calculations. It is possible that the first algorithms and analog calculations in mathematics were implemented with this mechanism, invented in the early first centuries BC. It has been selected for the cover to demonstrate the importance of calculations in science.
Radiochemistry and Nuclear Chemistry theme is a component of Encyclopedia of Chemical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The content of the Theme on Radiochemistry and Nuclear Chemistry provides the essential aspects and a myriad of issues of great relevance to our world such as: Isotope Effects, Isotope Separation and Isotope Fractionation; Radiometric Dating and Tracing; Radiochemical Techniques; Radionuclides in Chemical Research; Nuclear Methods in Material Research; Radiation Chemistry; Radiation Biology and Radiation Protection; Radiochemistry and Radiopharmaceutical Chemistry for Medicine; Chemistry of the Actinide Elements; Production And Chemistry Of Transactinide Elements; Nuclear Waste Management and the Nuclear Fuel Cycle; High-intensity Lasers in Nuclear Science; Nuclear Forensics; Nuclear Processes in Nature; Subatomic Particles, Nuclear Structure and Stability. These two volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.
Development and evaluation of radiolabeled neurotensin receptor antagonists as candidate ligands for PET/SPECT imaging and endoradiotherapy, doctoral thesis
Radiochemistry and Nuclear Chemistry theme is a component of Encyclopedia of Chemical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The content of the Theme on Radiochemistry and Nuclear Chemistry provides the essential aspects and a myriad of issues of great relevance to our world such as: Isotope Effects, Isotope Separation and Isotope Fractionation; Radiometric Dating and Tracing; Radiochemical Techniques; Radionuclides in Chemical Research; Nuclear Methods in Material Research; Radiation Chemistry; Radiation Biology and Radiation Protection; Radiochemistry and Radiopharmaceutical Chemistry for Medicine; Chemistry of the Actinide Elements; Production And Chemistry Of Transactinide Elements; Nuclear Waste Management and the Nuclear Fuel Cycle; High-intensity Lasers in Nuclear Science; Nuclear Forensics; Nuclear Processes in Nature; Subatomic Particles, Nuclear Structure and Stability. These two volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.
This revised and extended 6 volume handbook set is the most comprehensive and voluminous reference work of its kind in the field of nuclear chemistry. The Handbook set covers all of the chemical aspects of nuclear science starting from the physical basics and including such diverse areas as the chemistry of transactinides and exotic atoms as well as radioactive waste management and radiopharmaceutical chemistry relevant to nuclear medicine. The nuclear methods of the investigation of chemical structure also receive ample space and attention. The international team of authors consists of scores of world-renowned experts - nuclear chemists, radiopharmaceutical chemists and physicists - from Europe, USA, and Asia. The Handbook set is an invaluable reference for nuclear scientists, biologists, chemists, physicists, physicians practicing nuclear medicine, graduate students and teachers - virtually all who are involved in the chemical and radiopharmaceutical aspects of nuclear science. The Handbook set also provides further reading via the rich selection of references.
In the new edition of this very successful book, European and North American experts present the state of the art in diagnostic and therapeutic radionuclide procedures. The aim is to examine established and emerging clinical applications in detail, rather than to consider everything included in the comprehensive texts already available within the field. This “practical” approach ensures that the book will be a valuable guide for nuclear medicine physicians, technologists, students, and interested clinicians alike. This edition of Clinical Nuclear Medicine has been extensively revised to take account of recent developments. The roles of SPECT/CT, PET/CT, and PET/MRI are clearly explained and illustrated, and the coverage extended to encompass, for example, novel PET tracers and therapeutic radionuclides, advanced techniques of brain imaging, and the development of theranostics. Readers will be fully persuaded of the ever-increasing value of nuclear medicine techniques in depicting physiology and function and complementing anatomic modalities such as CT, MRI, and ultrasound.
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