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Quantum tunnelling is one of the strangest phenomena in chemistry, where we see the wave nature of atoms acting in “impossible” ways. By letting molecules pass through the kinetic barrier instead of over it, this effect can lead to chemical reactions even close to the absolute zero, to atypical spectroscopic observations, to bizarre selectivity, or to colossal isotopic effects. Quantum mechanical tunnelling observations might be infrequent in chemistry, but it permeates through all its disciplines producing remarkable chemical outcomes. For that reason, the 21st century has seen a great increase in theoretical and experimental findings involving molecular tunnelling effects, as well as in novel techniques that permit their accurate predictions and analysis. Including experimental, computational and theoretical chapters, from the physical and organic to the biochemistry fields, from the applied to the academic arenas, this new book provides a broad and conceptual perspective on tunnelling reactions and how to study them. Quantum Tunnelling in Molecules is the obligatory stop for both the specialist and those new to this world.
In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.
Tunneling in Biological Systems focuses on the low temperature electron transport that reveals a quantum-mechanical effect called "tunneling. This book discusses the tunneling in physical systems; detection of molecular vibrations with electron tunneling; chemical-rate theory of small-polaron hopping; and experimental approaches to electronic coupling in metal ion redox systems. The Faraday rotation and photoconductivity of photosynthetic structures at microwave frequencies; dynamics of electron transport in macromolecules; and electron transfer reactions in cytochrome oxidase are also elaborated. This text likewise covers the kinetic evidence for electron tunneling in solution; specificity and control in biological systems; molecular tunneling in heme proteins; and ligand binding. This publication is valuable to students and researchers interested in the physics of biological and medical problems.
Explores the role of quantum mechanics in biology for advanced undergraduate and graduate students in physics, biology and chemistry.
This book presents the hotly debated question of whether quantum mechanics plays a non-trivial role in biology. In a timely way, it sets out a distinct quantum biology agenda. The burgeoning fields of nanotechnology, biotechnology, quantum technology, and quantum information processing are now strongly converging. The acronym BINS, for Bio-Info-Nano-Systems, has been coined to describe the synergetic interface of these several disciplines. The living cell is an information replicating and processing system that is replete with naturally-evolved nanomachines, which at some level require a quantum mechanical description. As quantum engineering and nanotechnology meet, increasing use will be made of biological structures, or hybrids of biological and fabricated systems, for producing novel devices for information storage and processing and other tasks. An understanding of these systems at a quantum mechanical level will be indispensable.
New York Times bestseller • Life on the Edge alters our understanding of our world's fundamental dynamics through the use of quantum mechanics. Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation? Using first-hand experience at the cutting edge of science, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics. Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge illustrates one of life's puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision? Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe. Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden describe the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge. Winner, Stephen Hawking Medal for Science Communication
Quantum mechanical tunneling plays important roles in a wide range of natural sciences, from nuclear and solid-state physics to proton transfer and chemical reactions in chemistry and biology. Responding to the need for further understanding of multidimensional tunneling, the authors have recently developed practical methods that can be applied to