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LSD's short but colorful history in North America carries with it the distinct cachet of counterculture and government experimentation. The truth about this mind-altering chemical cocktail is far more complex—and less controversial—than generally believed. Psychedelic Psychiatry is the tale of medical researchers working to understand LSD’s therapeutic properties just as escalating anxieties about drug abuse in modern society laid the groundwork for the end of experimentation at the edge of psychopharmacology. Historian Erika Dyck deftly recasts our understanding of LSD to show it as an experimental substance, a medical treatment, and a tool for exploring psychotic perspectives—as well as a recreational drug. She recounts the inside story of the early days of LSD research in small-town, prairie Canada, when Humphry Osmond and Abram Hoffer claimed incredible advances in treating alcoholism, understanding schizophrenia and other psychoses, and achieving empathy with their patients. In relating the drug’s short, strange trip, Dyck explains how concerns about countercultural trends led to the criminalization of LSD and other so-called psychedelic drugs—concordantly opening the way for an explosion in legal prescription pharmaceuticals—and points to the recent re-emergence of sanctioned psychotropic research among psychiatric practitioners. This challenge to the prevailing wisdom behind drug regulation and addiction therapy provides a historical corrective to our perception of LSD’s medical efficacy.
In the early 1950s, the leading centre of the world for LSD research was Weyburn, Saskatchewan, where two psychiatrists sought to revolutionize the treatment of mental illness and, in the process, gave rise to a new form of therapy: psychedelic psychiatry. Psychedelic Psychiatry is the tale of medical researchers working to understand LSD’s therapeutic properties just as escalating anxieties about drug abuse in modern society laid the groundwork for the end of experimentation at the edge of psychopharmacology. Historian Erika Dyck deftly recasts our understanding of LSD to show it as an experimental substance, a medical treatment, and a tool for exploring psychotic perspectives. She recounts the inside story of the early days of LSD research in small-town, prairie Canada, when Humphry Osmond and Abram Hoffer claimed incredible advances in treating alcoholism, understanding schizophrenia and other psychoses, and achieving empathy with their patients. In relating the drug’s short, strange trip, Dyck explains how societal concerns about countercultural trends led to the criminalization of LSD and other so-called psychedelic drugs. In this well-written and fascinating book, she confronts the ethical dilemmas of the time and challenges the prevailing wisdom behind drug regulation and addiction therapy.
Praise for Second Edition of The Psychedelic Renaissance: 'Onward, intrepid explorer, keep your wits, while allowing them to be tickled, as Dr Sessa leads you into a world of remarkable wonders! You are in for a real treat!' Robin Carhart-Harris 'This new book is a succinct, entertaining overview of the emerging "Psychedelic Renaissance" written by an insider, and one of the brightest young architects of this new emerging paradigm.' Dr Dennis J. McKenna 'With intelligence, fact-based optimism and compassion Sessa throws open the doors of perception and guides the reader through the complexities of the history, pharmacology, legality and potential of these miraculous molecules.' Andy Roberts 'This new edition of Sessa's, The Psychedelic Renaissance, will encourage researchers to work in this field, to the benefit of our understanding of how the brain works and to develop new approaches to psychiatric disorders.' David Nutt 'Dr. Ben Sessa prescribes a way forward; mainstreaming psychedelics for a world in deep need of spirituality and inspiration. The Psychedelic Renaissance is a book that deserves to be widely read.' Rick Doblin 'Ben Sessa's energetic review of the research and cultural use of psychedelics provides a unique perspective. The way forward is clear: we urgently need more scientific research, and a rational reform of drug policies.' Amanda Feilding 'The Psychedelic Renaissance will inevitably and rightly be seen as an important marker of their assimilation into the cultural mainstream. I highly recommend it.' Ralph Metzner 'Dr. Sessa skilfully chronicles important developments, perhaps a turning point, in psychiatry and in the understanding of psychedelics in the wider culture. This new updated edition of The Psychedelic Renaissance is informative, entertaining and timely.' Michael Mithoefer
Recent clinical trials show that psychedelics such as LSD and psilocybin can be given safely in controlled conditions, and can cause lasting psychological benefits with one or two administrations. Supervised psychedelic sessions can reduce symptoms of anxiety, depression, and addiction, and improve well-being in healthy volunteers, for months or even years. But these benefits seem to be mediated by "mystical" experiences of cosmic consciousness, which prompts a philosophical concern: do psychedelics cause psychological benefits by inducing false or implausible beliefs about the metaphysical nature of reality? This book is the first scholarly monograph in English devoted to the philosophical analysis of psychedelic drugs. Its central focus is the apparent conflict between the growing use of psychedelics in psychiatry and the philosophical worldview of naturalism. Within the book, Letheby integrates empirical evidence and philosophical considerations in the service of a simple conclusion: this "Comforting Delusion Objection" to psychedelic therapy fails. While exotic metaphysical ideas do sometimes come up, they are not, on closer inspection, the central driver of change in psychedelic therapy. Psychedelics lead to lasting benefits by altering the sense of self, and changing how people relate to their own minds and lives-not by changing their beliefs about the ultimate nature of reality. The upshot is that a traditional conception of psychedelics as agents of insight and spirituality can be reconciled with naturalism (the philosophical position that the natural world is all there is). Controlled psychedelic use can lead to genuine forms of knowledge gain and spiritual growth-even if no Cosmic Consciousness or transcendent divine Reality exists. Philosophy of Psychedelics is an indispensable guide to the literature for researchers already engaged in the field of psychedelic psychiatry, and for researchers-especially philosophers-who want to become acquainted with this increasingly topical field.
The rise—and fall—of research into the therapeutic potential of LSD. After LSD arrived in the United States in 1949, the drug's therapeutic promise quickly captured the interests of psychiatrists. In the decade that followed, modern psychopharmacology was born and research into the drug's perceptual and psychological effects boomed. By the early 1960s, psychiatrists focused on a particularly promising treatment known as psychedelic therapy: a single, carefully guided, high-dose LSD session coupled with brief but intensive psychotherapy. Researchers reported an astounding 50 percent success rate in treating chronic alcoholism, as well as substantial improvement in patients suffering from a range of other disorders. Yet despite this success, LSD officially remained an experimental drug only. Research into its effects, psychological and otherwise, dwindled before coming to a close in the 1970s. In The Trials of Psychedelic Therapy, Matthew Oram traces the early promise and eventual demise of LSD psychotherapy in the United States. While the common perception is that LSD's prohibition terminated legitimate research, Oram draws on files from the Food and Drug Administration and the personal papers of LSD researchers to reveal that the most significant issue was not the drug's illegality, but the persistent question of its efficacy. The landmark Kefauver-Harris Drug Amendments of 1962 installed strict standards for efficacy evaluation, which LSD researchers struggled to meet due to the unorthodox nature of their treatment. Exploring the complex interactions between clinical science, regulation, and therapeutics in American medicine, The Trials of Psychedelic Therapy explains how an age of empirical research and limited government oversight gave way to sophisticated controlled clinical trials and complex federal regulations. Analyzing the debates around how to understand and evaluate treatment efficacy, this book will appeal to anyone with an interest in LSD and psychedelics, as well as mental health professionals, regulators, and scholars of the history of psychiatry, psychotherapy, drug regulation, and pharmaceutical research and development.
We are in the midst of what is being called the 'psychedelic renaissance' with growing interest into how psychedelics alter consciousness, brain function and brain connectivity. The acute, often profound, effects of the psychedelic experience can induce lasting improvements in mental health demonstrating that chemistry forms the basis of mystical experience, consciousness and mental wellbeing. - This volume is a collection of chapters by world leaders in fields of neurobiology, neuropsychiatry, psychology, ethnography and pharmacology, addressing the neurobiological mechanisms of action of various classic and atypical psychedelics, their therapeutic potential as well as the possible risks associated with their use
This handbook reviews promising applications of psychedelics in treatment of such challenging psychiatric problems as posttraumatic stress disorder, major depression, substance use disorders, and end-of-life anxiety. Experts from multiple disciplines synthesize current knowledge on psilocybin, MDMA, ketamine, and other medical hallucinogens. The volume comprehensively examines these substances' neurobiological mechanisms, clinical effects, therapeutic potential, risks, and anthropological and historical contexts. Coverage ranges from basic science to practical clinical considerations, including patient screening and selection, dosages and routes of administration, how psychedelic-assisted sessions are structured and conducted, and management of adverse reactions.
A recent wave of research in psychiatry and neuroscience has re-examined the properties of “classic” psychedelic substances - also known as serotonergic hallucinogens - such as psilocybin, LSD, and DMT. Evidence to date suggests that psychedelics can be given safely in controlled conditions, at moderate to high doses, and may have potential as therapeutic agents in the treatment of various addictive and mood disorders. The main mechanism of action appears to be the induction of a dramatically altered state of consciousness, but the details of how psychedelic-assisted psychotherapy works are hotly debated, as are the relations between psychedelic experiences themselves and the neural changes induced by the drugs. Philosophical Perspectives on Psychedelic Psychiatry addresses the fascinating philosophical questions raised by the renewed psychiatric use of psychedelics, with chapters from leading philosophers of mind, science, and psychiatry centred around three main themes. Chapters in the “self and mind” section ask: what can we learn about the self and the mind from psychedelic science? Chapters in the “science and psychiatry” section address methodological, theoretical, and clinical questions concerning how psychedelics can best be studied scientifically and used therapeutically, and how they might work to relieve psychiatric suffering. Finally, chapters in the “ethics and spirituality” section address broader questions about the interpretation of psychedelic experience, its ethical implications, and its possible role(s) in the broader culture.
Psychedelics as therapeutic catalysts for emotional and spiritual transformation • Explores the latest medical research on the healing powers of entheogens • Reveals the crucial role of tribal and shamanic wisdom in psychedelic medicine • Provides guidelines for working with psychedelics, including the author’s personal healing and recommendations for creating change on the spiritual and societal levels Banned after promising research in the 1940s, ’50s, and ’60s, the use of psychedelics as therapeutic catalysts is now being rediscovered at prestigious medical schools, such as Harvard, Johns Hopkins, NYU, and UCLA. Through clinical trials to assess their use, entheogens have been found to ease anxiety in the dying, interrupt the hold of addictive drugs, cure post-traumatic stress disorder, and treat other deep-seated emotional disturbances. To date, results have been positive, and the idea of psychedelics as powerful psychiatric--and spiritual--medicines is now beginning to be accepted by the medical community. Exploring the latest cutting-edge research on psychedelics, along with their use in indigenous cultures throughout history for rites of passage and shamanic rituals, Neal Goldsmith reveals that the curative effect of entheogens comes not from a chemical effect on the body but rather by triggering a peak or spiritual experience. He provides guidelines for working with entheogens, groundbreaking analyses of the concept--and the process--of change in psychotherapy, and, ultimately, his own story of psychedelic healing. Examining the tribal roots of this knowledge, Goldsmith shows that by combining ancient wisdom and modern research, we can unlock the emotional, mental, and spiritual healing powers of these unique and powerful tools, providing an integral medicine for postmodern society.
This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds.