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This book collects the publications of Shinya lnou‚, pioneering cell biophysicist and winner of the 2003 International Prize for Biology. The articles cover the discovery, and elucidate the behavior in living cells, of the dynamic molecular filaments which organize the cell and play a central role in cell division. Other articles report on the development of microscopes, especially those using polarized light and digital image enhancement, which make possible studies of the ever-changing molecular architecture directly in living cells. This book also contains many high quality photo-micrographs as well as an appended DVD with an extensive collection of video movies of active living cells. After training in Tokyo and at Princeton University, Dr Inou‚ has held teaching positions at the University of Washington, Tokyo Metropolitan University, University of Rochester, Dartmouth Medical School, and University of Pennsylvania. He is a member of the U.S. National Academy of Sciences and currently holds the title of Distinguished Scientist at the Marine Biological Laboratory in Woods Hole, Massachusetts.
This book is the first comprehensive description of development of the Acipenserid fish published in the English language. It con tains the results of more than 40 years of studies by the authors and their colleagues. My own life in science has been intimately related both with the authors and the fish, which are the subject of this book. Therefore, it gives me a great pleasure to present to the English reader an expanded version of the book. Those interested in the history of biology must be well aware of the fact that genetics in the USSR was practically demolished by Lysenko at the session of the Lenin All-Union Academy of Agricultural Sciences in 1948. However, it is much less well known that other fundamental branches of biology were also persecuted at that time, experimental embryology (developmental mechanics) among them. As a result, many embryologists, in cluding the authors of this book, were forced to turn to more ap plied problems, this being the only way to continue research. They had to abandon amphibians and concentrate their efforts on sturgeon.
The subject of this book is time, one of the small number of elusive essences of the world, unsubdued by human will. The three global problems of natural science, those of the origin of the Universe, life and consciousness, cannot be solved without finding out the nature of time. Without a good construction of time it is impossible to describe, to qualify, to forecast and to control various processes in the animate and inanimate nature. Special attention is paid to the ways of adequate inclusion of the properties of time in the derivation of the fundamental equations of motion for natural systems.