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Calculation in pharmacy is wide and broad-based starting from dispensing to manufacturing, quality control, research and development in pharmaceutical industries. This is an important subject area for any student pursuing pharmacy course irrespective of level of the course. Thus, the students during their course of studies and pharmaceutical technologists during their work need to know calculations related to (1) Physical and chemical properties of active ingredients and excipients, (2) Rate of absorption, (3) Biological activity, and (4) Rate of degradation of the drug substances. There is need to have such book on pharmaceutical calculations that can fulfill the needs of Institutions as well as industries. The book, Elementary Pharmaceutical Calculations has been designed so that it can meet the needs of students. The content of the book has been divided into 13 chapters. Each chapter begins with introductory description of concept, relevant formulas with derivation and then examples to explain how the formula can be used to solve problems; finally at the end there are problems given to solve.
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Designed as a highly visual and practical resource to be used across the spectrum of lifelong learning, Ballweg's Physician Assistant, 7th Edition, helps you master all the core competencies needed for physician assistant certification, recertification, and clinical practice. It remains the only textbook that covers all aspects of the physician assistant profession, the PA curriculum, and the PA's role in clinical practice. Ideal for both students and practicing PAs, it features a succinct, bulleted writing style, convenient tables, practical case studies, and clinical application questions that enable you to master key concepts and clinical applications. - Addresses all six physician assistant competencies, as well as providing guidance for the newly graduated PA entering practice. - Includes five new chapters: What Is a Physician Assistant, and How Did We Get Here?, Effective Use of Technology for Patient-Centered Care, Success in the Clinical Year, Transitioning to Practice and Working in Teams, and Finding Your Niche. - Features an enhanced focus on content unique to the PA profession that is not readily found in other resources, more illustrations for today's visually oriented learners, a more consistent format throughout, and a new emphasis on the appropriate use of social media among healthcare professionals. - Provides updated content throughout to reflect the needs of the PA profession, including new content on self-care for the PA to help prevent burnout, suicide, and other hazards faced by healthcare professionals. - Guides students in preparation for each core clinical rotation and common electives, as well as working with special patient populations such as patients experiencing homelessness and patients with disabilities. - Includes quick-use resources, such as objectives and key points sections for each chapter, tip boxes with useful advice, abundant tables and images, and more than 130 updated case studies. - Evolve Educator site with an image bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.